Product image of Miacalcic (Calcitonin Salmon, Synthetic) supplied by GNH India

Miacalcic

Active Ingredient:
Calcitonin Salmon, Synthetic
Origin:
EU

Miacalcic (Calcitonin Salmon, Synthetic)

Calcitonin salmon, the active ingredient in Miacalcic, is a calcitonin presented as an injectable solution for intramuscular, intravenous, or subcutaneous use. It is employed to manage osteoporosis, Paget's disease of bone, and hypercalcemia of malignancy in adult patients.

GNH India supplies Miacalcic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Essential Pharma (M) Limited

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Indications & Clinical Uses

  • Miacalcic is a calcitonin analogue that acts on bone metabolism disorders and calcium dysregulation.
  • Osteoporosis: helps reduce bone turnover and supports maintenance of bone mineral density.
  • Paget's disease of bone: normalises abnormal bone remodeling and reduces disease‑related pain.
  • Hypercalcemia of malignancy: lowers elevated serum calcium levels by inhibiting bone resorption and enhancing renal calcium excretion.

How It Works

  • Calcitonin salmon binds to calcitonin receptors on osteoclasts, inhibiting their activity and thereby decreasing bone resorption. The reduced osteoclastic activity lowers the release of calcium from bone into the bloodstream, while concurrent renal effects increase calcium excretion, resulting in lowered serum calcium concentrations.

Side Effects

Miacalcic may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea or vomiting
  • Flushing or warmth sensation
  • Headache or dizziness
  • Mild injection‑site pain or erythema

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reactions
  • Marked hypocalcemia with neuromuscular symptoms
  • Hypotension or syncope
  • Severe injection‑site infection or abscess

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate calcium status and renal function.
  • Assess calcium levels before use: ensure baseline serum calcium is within normal range.
  • Monitor for signs of hypocalcemia: watch for tingling, muscle cramps, or seizures.
  • Use with caution in renal impairment: adjust monitoring frequency.
  • Avoid in known hypersensitivity: discontinue if allergic reaction occurs.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Calcitonin may interact with several agents that affect calcium balance or renal function.

Major Interactions (Avoid)

  • Calcium supplements: may diminish calcitonin efficacy.
  • NSAIDs: increase risk of renal impairment.
  • Loop diuretics: alter calcium handling and may exacerbate hypocalcemia.
  • Warfarin: potential for increased bleeding risk.

Moderate Interactions (Monitor Closely)

  • Bisphosphonates: additive inhibition of bone resorption.
  • Systemic steroids: may affect calcium metabolism.
  • Anticonvulsants (e.g., phenytoin): can modify calcium levels.

Frequently Asked Questions

Miacalcic is indicated for the treatment of osteoporosis, Paget's disease of bone, and hypercalcemia of malignancy. In each condition it helps lower elevated calcium levels or stabilise bone turnover, providing clinical benefit in adult patients.

Calcitonin salmon binds to specific calcitonin receptors on osteoclasts, suppressing their bone‑resorbing activity. This reduces calcium release from bone and promotes renal calcium excretion, leading to lower serum calcium concentrations and improved bone stability.

The dose of Miacalcic is determined by the prescribing clinician based on the patient’s condition, severity, and response. Dosage regimens are individualised and should follow the prescriber’s instructions and local clinical guidelines.

Safety of calcitonin salmon in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Miacalcic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

The primary alternative class is bisphosphonates, which also inhibit bone resorption but act through different cellular pathways. Calcitonin provides a rapid, short‑term reduction in serum calcium and is useful when a quick response is needed, whereas bisphosphonates have a longer‑lasting effect on bone density.

Miacalcic must be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use and avoid exposing it to temperatures outside the recommended range.

Miacalcic is supplied as an injectable solution and can be given by intramuscular, intravenous, or subcutaneous injection. The route, site and frequency are selected by the prescriber according to the therapeutic indication and patient needs.

Serious adverse events include severe allergic reactions such as anaphylaxis, marked hypocalcemia that can cause neuromuscular symptoms, hypotension, and injection‑site infections. Patients should be monitored closely for these signs, and treatment should be stopped immediately if they occur.

Miacalcic is contraindicated in individuals with known hypersensitivity to calcitonin salmon or any excipients in the formulation. Caution is also advised for patients with severe renal impairment or those who have experienced severe hypocalcemia previously.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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