Mialdex (Dexketoprofen Trometamol)

Dexketoprofen Trometamol is used to manage pain and inflammation in several clinical settings.

• Mild to moderate pain: provides rapid analgesia for acute pain episodes, improving patient comfort and functional ability.
• Post‑operative pain: reduces pain and inflammation after surgical procedures, facilitating early mobilization and recovery.
• Musculoskeletal pain: alleviates pain associated with strains, sprains and overuse injuries, supporting return to activity.
• Inflammatory conditions: helps control inflammation in conditions such as bursitis or tendonitis, decreasing swelling and discomfort.

• Dexketoprofen Trometamol exerts its effect by non‑selectively inhibiting cyclooxygenase enzymes COX‑1 and COX‑2, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitisation of nociceptors and decreases inflammatory mediators, resulting in analgesic and anti‑inflammatory actions. The trometamol salt enhances aqueous solubility, allowing rapid intravenous or intramuscular administration and quick plasma concentrations, which contributes to its fast onset of analgesia.

Dexketoprofen Trometamol may cause adverse reactions, which are categorised by frequency and severity.

Common Side Effects

• Nausea: mild gastrointestinal upset.
• Headache: transient headache.
• Dizziness: light‑headed sensation.
• Injection site pain: discomfort at the site of administration.

Serious or Rare Side Effects

• Gastrointestinal bleeding: severe ulceration or hemorrhage.
• Renal impairment: sudden decrease in kidney function.
• Allergic reactions: rash, pruritus, or anaphylaxis.

When prescribing Dexketoprofen Trometamol, clinicians should consider several precautions to minimise risk.

• Assess renal function: avoid use in patients with severe renal impairment.
• Evaluate gastrointestinal risk: use cautiously in those with history of ulcers or bleeding.
• Monitor cardiovascular status: NSAIDs may increase risk of thrombotic events.
• Check for hypersensitivity: discontinue if signs of allergic reaction appear.
• Use lowest effective dose: limit duration to the shortest necessary period.
• Store at ambient temperature: keep below 25°C, protect from moisture and light in original packaging.

Dexketoprofen Trometamol can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
• Corticosteroids: additive risk of ulceration.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce renal function.
• Diuretics: potential for decreased renal perfusion.
• Lithium: NSAIDs can raise lithium levels.