Product image of Mianserine Eg (Mianserin Hydrochloride) supplied by GNH India

Mianserine Eg

Active Ingredient:
Mianserin Hydrochloride
Origin:
EU

Mianserine Eg (Mianserin Hydrochloride)

Mianserin, the active ingredient in Mianserine Eg, is a tetracyclic antidepressant presented as a tablet for oral use. It is indicated for the treatment of major depressive disorder in adult patients.

GNH India supplies Mianserine Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eg Labo Laboratoires Eurogenerics

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Indications & Clinical Uses

Mianserin is used in the management of depressive disorders.

  • Major depressive disorder: reduces depressive symptoms and improves mood in adult patients.

How It Works

  • Mianserin acts primarily as an antagonist of central presynaptic α2‑adrenergic receptors, enhancing norepinephrine release. It also blocks several serotonin receptors, especially 5‑HT2 and 5‑HT3, which increases serotonergic neurotransmission. These combined actions contribute to its antidepressant effect.

Side Effects

Mianserin may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Drowsiness
  • Dry mouth
  • Constipation
  • Weight gain
  • Dizziness

Serious or Rare Side Effects

  • Agranulocytosis
  • Seizures
  • Cardiac arrhythmias

Precautions & Warnings

When prescribing Mianserin, clinicians should consider several safety precautions.

  • Monitor blood pressure: watch for orthostatic hypotension, especially at treatment initiation.
  • Assess for suicidal thoughts: evaluate risk especially in early therapy.
  • Caution in hepatic impairment: adjust use if liver function is compromised.
  • Avoid abrupt discontinuation: taper dose to reduce withdrawal symptoms.
  • Use cautiously in elderly: increased sensitivity to sedative effects.
  • Store at room temperature: keep in the original container, protect from moisture.

Avoid Interactions

Mianserin can interact with other medicines, requiring attention to potential additive effects.

Major Interactions (Avoid)

  • MAO inhibitors: concurrent use can cause hypertensive crisis.
  • SSRIs or other serotonergic agents: risk of serotonin syndrome.
  • Tramadol: increased risk of seizures and serotonin syndrome.
  • Linezolid: similar serotonergic risk.
  • Other tetracyclic antidepressants: additive CNS depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine): may increase Mianserin plasma levels.
  • Antihypertensive drugs: additive hypotensive effect.
  • CNS depressants (e.g., benzodiazepines): enhanced sedation.
  • Alcohol: may intensify drowsiness.
  • Anticholinergic medications: increased anticholinergic burden.

Frequently Asked Questions

Mianserine Eg contains the active ingredient Mianserin, which is prescribed for the treatment of major depressive disorder in adult patients. It helps alleviate depressive symptoms by modulating neurotransmitter activity in the brain.

Mianserin works by blocking presynaptic α2‑adrenergic receptors, leading to increased release of norepinephrine, and by antagonising certain serotonin receptors (5‑HT2 and 5‑HT3). This dual action enhances both norepinephrine and serotonin neurotransmission, contributing to its antidepressant effect.

The appropriate dose of Mianserine Eg is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and tolerability. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for Mianserin in pregnancy and lactation are limited. It is generally classified as having an unknown pregnancy category, and use is only recommended if the potential benefits outweigh the possible risks to the fetus or infant.

To order Mianserine Eg, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Mianserin belongs to the tetracyclic antidepressant class, differing from selective serotonin reuptake inhibitors (SSRIs) and serotonin‑norepinephrine reuptake inhibitors (SNRIs) in its receptor‑blocking profile. It may be chosen when patients experience inadequate response or intolerable side effects with other antidepressant classes.

Mianserine Eg should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability and potency.

Mianserine Eg is taken orally, usually as a tablet, with or without food as directed by the prescriber. Patients should swallow the tablet whole and avoid crushing or chewing it unless specifically instructed.

Serious risks include agranulocytosis, seizures, and cardiac arrhythmias. Patients should promptly report signs of infection, unexplained fever, fainting, palpitations, or any new neurological symptoms to their healthcare provider.

Mianserine Eg is contraindicated in individuals who are currently taking monoamine oxidase inhibitors (MAOIs) or have a known hypersensitivity to Mianserin or any of its excipients. Caution is also advised for patients with severe hepatic impairment or uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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