Product image of Mibetin (Betamethasone Dipropionate, Gentamicin Sulfate) supplied by GNH India

Mibetin

Active Ingredient:
Betamethasone Dipropionate, Gentamicin Sulfate
Origin:
EU

Mibetin (Betamethasone Dipropionate, Gentamicin Sulfate)

Betamethasone dipropionate and Gentamicin sulfate, the active ingredients in Mibetin, are a corticosteroid/antibiotic combination presented as a topical formulation for skin application. They are used to reduce inflammation and treat bacterial infection in inflammatory skin conditions such as eczema, dermatitis, and infected psoriasis in adult and pediatric patients.

GNH India supplies Mibetin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows stringent quality standards and provides regulatory documentation for global distribution, including batch release certificates and stability data.

Manufacturer / TM Owner

Mibe Pharma Uk Ltd

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Indications & Clinical Uses

  • Mibetin combines a corticosteroid and an antibiotic to treat inflammatory and infected skin conditions.
  • Eczema: reduces inflammation and controls secondary bacterial infection.
  • Contact dermatitis: alleviates redness, swelling and prevents bacterial colonisation.
  • Infected psoriasis: diminishes plaque inflammation while treating accompanying bacterial infection.

How It Works

  • Betamethasone dipropionate binds glucocorticoid receptors, modulating gene transcription to suppress pro‑inflammatory cytokines, while Gentamicin sulfate attaches to the bacterial 30S ribosomal subunit, inhibiting protein synthesis and leading to bacterial cell death. The combined actions provide anti‑inflammatory and antibacterial effects at the site of application.

Side Effects

Topical application of Mibetin may be associated with local adverse reactions.

Common Side Effects

  • Skin irritation: mild redness or burning at the application site.
  • Pruritus: itching sensation.
  • Dryness: localized skin dryness.
  • Folliculitis: small pustules around hair follicles.

Serious or Rare Side Effects

  • Hypersensitivity: severe rash, swelling or anaphylaxis.
  • Skin atrophy: thinning of the epidermis with prolonged use.
  • Secondary infection: overgrowth of non‑susceptible organisms.
  • Systemic corticosteroid effects: adrenal suppression with extensive application.

Precautions & Warnings

  • Before using Mibetin, consider the following precautions to minimise risks.
  • Assess infection type: confirm bacterial involvement to justify Gentamicin use.
  • Limit duration: use for the shortest effective period to reduce steroid‑related skin changes.
  • Avoid occlusion: do not cover treated area with airtight dressings unless directed.
  • Monitor for systemic absorption: especially in extensive or broken skin, watch for adrenal effects.
  • Pregnancy and lactation: discuss potential risks with a healthcare professional.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Mibetin may interact with other medications applied to the skin or systemic agents.

Major Interactions (Avoid)

  • Concurrent use of other potent topical steroids: may increase risk of skin atrophy.
  • Systemic corticosteroids: additive systemic glucocorticoid effects.

Moderate Interactions (Monitor Closely)

  • Topical calcineurin inhibitors: monitor for combined immunosuppression.
  • Antibiotics with ototoxic potential: caution if large areas applied near ears.
  • Antifungal agents: may reduce efficacy of Gentamicin against mixed infections.

Frequently Asked Questions

Mibetin is a topical combination of betamethasone dipropionate and gentamicin sulfate indicated for the treatment of inflammatory skin disorders such as eczema and contact dermatitis, as well as for dermatoses that are complicated by bacterial infection, including infected psoriasis. It helps to relieve redness, swelling, itching and to eradicate susceptible bacteria on the skin.

Betamethasone dipropionate is a potent glucocorticoid that binds to intracellular glucocorticoid receptors. This interaction alters gene transcription, leading to decreased production of pro‑inflammatory cytokines, reduced leukocyte migration, and overall suppression of the inflammatory response in the treated skin area.

The prescribed dose of Mibetin is determined by the treating clinician based on the severity of the condition, the area of skin involved, and patient age. Typically, a thin layer is applied to the affected area once or twice daily, but exact frequency and duration should follow the prescriber’s instructions.

Safety data for Mibetin in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against possible risks before prescribing it to pregnant or nursing women. The decision to use the product should be made in consultation with a qualified medical professional.

To order Mibetin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Mibetin combines a high‑potency corticosteroid (betamethasone dipropionate) with a broad‑spectrum aminoglycoside (gentamicin). Compared with lower‑potency steroid‑antibiotic products, it may offer faster inflammation control but also carries a higher risk of steroid‑related skin changes. Choice of product should be guided by the severity of inflammation and the susceptibility of the infecting organism.

Store Mibetin at ambient temperature, preferably below 25 °C. Keep the tube or container tightly closed, protect it from moisture and direct sunlight, and store it in its original packaging until use. Do not freeze the product.

Mibetin is applied topically to clean, dry skin. A thin film should be spread over the affected area using clean fingertips or a sterile applicator. The area can be gently massaged until the product is absorbed. Follow the prescriber’s guidance on frequency and duration of treatment.

Serious risks include systemic corticosteroid effects such as adrenal suppression when large skin areas are treated, severe allergic reactions (e.g., anaphylaxis), and secondary infections caused by resistant organisms. Patients should seek immediate medical attention if they notice widespread rash, swelling, difficulty breathing, or signs of infection worsening.

Mibetin should be avoided in individuals with known hypersensitivity to betamethasone, gentamicin, or any excipients in the formulation. It is also contraindicated on viral skin infections (e.g., herpes simplex), fungal infections, or in patients with untreated tuberculosis of the skin. Consultation with a healthcare professional is essential before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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