Product image of Mibg (123i) Curium Netherlands (Iodine (123i) Iobenguane) supplied by GNH India

Mibg (123i) Curium Netherlands

Active Ingredient:
Iodine (123i) Iobenguane
Origin:
EU

Mibg (123i) Curium Netherlands (Iodine (123i) Iobenguane)

Iobenguane (I-123), the active ingredient in Mibg (123i) Curium Netherlands, is a radiopharmaceutical presented as an injectable solution for intravenous use. It is used for diagnostic imaging of cardiac sympathetic innervation, pheochromocytoma, and neuroblastoma in patients requiring functional assessment.

GNH India supplies Mibg (123i) Curium Netherlands as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Curium Netherlands B.V.

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Indications & Clinical Uses

Iobenguane (I-123) is employed in nuclear medicine to visualize sympathetic nerve activity and catecholamine‑producing tumors.

  • Cardiac sympathetic innervation imaging: enables assessment of myocardial sympathetic nerve function in heart failure patients.
  • Pheochromocytoma detection: identifies catecholamine‑secreting adrenal tumors for pre‑operative planning.
  • Neuroblastoma imaging: visualizes neuroblastoma lesions to aid staging and treatment monitoring.

How It Works

  • Iobenguane I-123 is a norepinephrine analog that is actively transported into sympathetic nerve terminals via the norepinephrine transporter (NET). Once inside, it is stored in synaptic vesicles and emits gamma photons detectable by SPECT cameras, allowing visualization of neuronal uptake and storage patterns in target tissues.

Side Effects

Adverse reactions may occur following administration of Iobenguane I-123.

Common Side Effects

  • Nausea: mild, transient discomfort.
  • Headache: mild to moderate intensity.
  • Flushing: brief skin reddening.
  • Injection site pain: localized discomfort.
  • Transient hypertension: temporary rise in blood pressure.
  • Dizziness: mild vertigo.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Severe hypotension: marked drop in blood pressure.
  • Radiation‑induced thyroid dysfunction: potential alteration of thyroid hormone levels.
  • Cardiac arrhythmia: irregular heart rhythm.
  • Pulmonary edema: fluid accumulation in lungs.
  • Radiation‑induced malignancy: extremely rare long‑term risk.

Precautions & Warnings

Use of Iobenguane I-123 requires careful consideration of patient factors and handling procedures.

  • Pregnancy: risk unknown; avoid unless essential.
  • Breastfeeding: risk unknown; consider discontinuing breastfeeding.
  • Renal impairment: monitor renal function and adjust imaging schedule if needed.
  • Thyroid blocking: assess need for iodine prophylaxis to reduce thyroid uptake.
  • Hypersensitivity: contraindicated in patients with known allergy to the radiotracer.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Iobenguane I-123 may interact with drugs affecting norepinephrine pathways or radiation exposure.

Major Interactions (Avoid)

  • Reserpine or guanethidine: reduce tracer uptake.
  • Potassium iodide or other thyroid blocking agents: interfere with thyroid imaging.
  • High‑dose catecholamines: compete for NET transport.
  • Concurrent I‑123 radiopharmaceuticals: increase cumulative radiation dose.
  • MAO inhibitors: may alter catecholamine metabolism.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may affect hemodynamic response.
  • Sympathomimetic agents (e.g., epinephrine): alter tracer distribution.
  • Diuretics: influence renal clearance of the tracer.
  • Iodinated contrast agents: may affect image interpretation.
  • Other diagnostic radiopharmaceuticals: require dose timing adjustments.

Frequently Asked Questions

Iobenguane (I-123) is a radiopharmaceutical used in nuclear medicine to image sympathetic nerve activity. It helps assess cardiac sympathetic innervation in heart failure, detect catecholamine‑producing tumors such as pheochromocytoma, and visualize neuroblastoma lesions for staging and treatment monitoring.

Iobenguane (I-123) mimics norepinephrine and is taken up by the norepinephrine transporter into sympathetic nerve endings. Once stored in vesicles, it emits gamma photons that are captured by a SPECT camera, providing a functional image of neuronal uptake and storage in the targeted tissue.

The administered activity of Iobenguane (I-123) is determined by the prescribing physician based on the specific diagnostic indication, patient weight, and imaging protocol. Dosage is individualized and should follow the radiopharmacy’s preparation guidelines.

The safety of Iobenguane (I-123) in pregnancy and lactation has not been established. It should be avoided unless the diagnostic benefit outweighs potential risks, and appropriate precautions such as thyroid blocking may be considered.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Iobenguane (I-123) is a norepinephrine analog specifically designed for SPECT imaging, offering high specificity for sympathetic nerve terminals. Compared with agents like 123I‑MIBG, it provides similar diagnostic information but may differ in kinetic properties and imaging protocols, influencing image quality and timing.

The product must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. It should be kept in its original container until use and handled by trained personnel using appropriate radiation safety measures.

Iobenguane (I-123) is administered as a single intravenous injection under aseptic conditions. The injection is typically performed in a nuclear medicine department, followed by a waiting period to allow tracer distribution before imaging with a gamma camera or SPECT system.

Serious risks include severe allergic reactions such as anaphylaxis, significant hypotension, radiation‑induced thyroid dysfunction, cardiac arrhythmias, and, rarely, radiation‑induced malignancies. Patients should be monitored closely during and after administration for any adverse events.

Iobenguane (I-123) is contraindicated in individuals with known hypersensitivity to the radiotracer or its components. It should also be avoided in pregnant women unless absolutely necessary, and used with caution in patients with severe renal impairment, uncontrolled hypertension, or significant cardiac arrhythmias.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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