Product image of Micafungin Accord (Micafungin) supplied by GNH India

Micafungin Accord

Active Ingredient:
Micafungin
Origin:
EU

Micafungin Accord (Micafungin)

Micafungin, the active ingredient in Micafungin Accord, is an echinocandin antifungal presented as an intravenous injection solution for intravenous use. It treats invasive Candida infections and is used for prophylaxis in patients undergoing hematopoietic stem cell transplantation.
GNH India supplies Micafungin Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare B.V.

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Indications & Clinical Uses

Micafungin Accord is an echinocandin antifungal indicated for several serious Candida infections.

  • Invasive candidiasis: eradicates bloodstream and deep‑tissue Candida infections.
  • Esophageal candidiasis: clears fungal lesions in the esophagus.
  • Candidemia: eliminates Candida organisms from the blood.
  • Prophylaxis in hematopoietic stem cell transplantation: prevents Candida infection during immune suppression.

How It Works

  • Micafungin inhibits the enzyme β‑(1,3)‑D‑glucan synthase, which is essential for synthesizing β‑(1,3)‑D‑glucan, a critical component of the fungal cell wall. By disrupting cell‑wall formation, the drug leads to osmotic instability and fungal cell lysis, while having minimal effect on human cells that lack this pathway.

Side Effects

Micafungin Accord may cause adverse reactions that vary in frequency and severity.

Common Side Effects

  • Elevated liver enzymes: transient increase in ALT or AST.
  • Fever: mild to moderate temperature rise.
  • Nausea: occasional gastrointestinal discomfort.
  • Headache: mild, self‑limiting.

Serious or Rare Side Effects

  • Hepatotoxicity: significant liver injury requiring monitoring.
  • Severe hypersensitivity: rash, angioedema, or anaphylaxis.
  • Infusion-related reactions: hypotension, dyspnea, or chest discomfort.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Liver function monitoring: assess baseline enzymes and repeat during treatment.
  • Renal function assessment: adjust use in severe renal impairment if needed.
  • Concomitant antifungal therapy: avoid overlapping agents with similar mechanisms.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Storage: Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Micafungin may interact with other medicines; awareness of interaction severity guides clinical decisions.

Major Interactions (Avoid)

  • Cyclosporine: increased cyclosporine exposure may raise toxicity risk.
  • Rifampin: may reduce micafungin plasma concentrations, compromising efficacy.

Moderate Interactions (Monitor Closely)

  • Azole antifungals (e.g., fluconazole): potential additive hepatotoxicity.
  • Immunosuppressants (e.g., tacrolimus): monitor drug levels for possible changes.
  • Warfarin: observe INR for any alteration in anticoagulant effect.

Frequently Asked Questions

Micafungin Accord is prescribed for serious Candida infections such as invasive candidiasis, esophageal candidiasis, and candidemia, and it is also used as prophylaxis against Candida infections in patients undergoing hematopoietic stem cell transplantation.

Micafungin blocks the enzyme β‑(1,3)‑D‑glucan synthase, preventing the synthesis of β‑(1,3)‑D‑glucan, an essential structural component of the fungal cell wall. This disruption weakens the wall, leading to cell lysis and death of the fungus.

The specific dose and duration of Micafungin Accord are determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and other clinical factors.

Safety data for micafungin in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Micafungin belongs to the echinocandin class, which targets the fungal cell wall, unlike azoles that inhibit ergosterol synthesis. Echinocandins are generally effective against Candida species, including some azole‑resistant strains, and have a lower risk of drug‑drug interactions compared with many azoles.

Micafungin Accord should be stored refrigerated at 2‑8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution to maintain stability.

Micafungin Accord is given as an intravenous injection. The infusion is typically administered over a period of 30‑60 minutes, depending on the clinical protocol and patient tolerance, under the supervision of qualified healthcare personnel.

Serious risks include hepatotoxicity, severe hypersensitivity reactions such as anaphylaxis, and infusion‑related events like hypotension or respiratory distress. Patients should be monitored for signs of liver dysfunction and allergic responses throughout therapy.

Micafungin Accord is contraindicated in patients with known hypersensitivity to micafungin or any component of the formulation. Caution is also advised for individuals with severe hepatic impairment, unless the prescriber determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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