Product image of Micafungin Accord (Micafungin) supplied by GNH India

Micafungin Accord

Active Ingredient:
Micafungin
Origin:
EU

Micafungin Accord (Micafungin)

Micafungin, the active ingredient in Micafungin Accord, is an echinocandin presented as an injectable solution for intravenous use. It treats invasive candidiasis and other Candida infections in adult and pediatric patients.

GNH India supplies Micafungin Accord as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Accord Healthcare Polska Sp. Z O.O.

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Indications & Clinical Uses

Micafungin is an echinocandin antifungal that inhibits fungal cell wall synthesis, primarily used for serious Candida infections.

  • Invasive candidiasis: effective treatment of bloodstream and deep‑tissue Candida infections.
  • Esophageal candidiasis: resolves mucosal infection in immunocompromised individuals.
  • Prophylaxis of Candida infections: prevents invasive disease in patients undergoing hematopoietic stem cell transplantation.

How It Works

  • Micafungin inhibits the enzyme β‑(1,3)‑D‑glucan synthase, which is essential for synthesizing β‑(1,3)‑D‑glucan, a critical component of the fungal cell wall. Disruption of this pathway weakens the cell wall, leading to osmotic instability and fungal cell death, while having minimal effect on human cells.

Side Effects

Common Side Effects

  • Fever: transient elevation of body temperature during infusion.
  • Nausea: mild gastrointestinal discomfort.
  • Elevated liver enzymes: increase in ALT/AST values.
  • Headache: mild to moderate headache.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate treatment.
  • Hepatic dysfunction: significant liver injury with jaundice.
  • Severe hypotension: marked drop in blood pressure during infusion.

Precautions & Warnings

Precautions should be taken to ensure safe administration of Micafungin.

  • Liver function monitoring: check ALT/AST before and during therapy.
  • Renal function assessment: evaluate creatinine clearance in patients with kidney impairment.
  • Hypersensitivity caution: discontinue if signs of allergic reaction appear.
  • Pediatric dosing consideration: use only under specialist supervision.
  • Drug interaction review: assess concomitant medications that affect hepatic metabolism.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Micafungin may interact with several medications; review is essential.

Major Interactions (Avoid)

  • Cyclosporine: increased micafungin exposure, risk of toxicity.
  • Rifampin: reduced micafungin concentrations, possible treatment failure.
  • Strong enzyme inducers (e.g., carbamazepine): lower micafungin levels.

Moderate Interactions (Monitor Closely)

  • Azole antifungals (e.g., fluconazole): potential additive hepatotoxicity.
  • Warfarin: possible alteration of INR, monitor coagulation.

Frequently Asked Questions

Micafungin Accord is used to treat serious Candida infections, including invasive candidiasis and esophageal candidiasis, and may be employed as prophylaxis in patients at high risk, such as those undergoing hematopoietic stem cell transplantation.

Micafungin inhibits the fungal enzyme β‑(1,3)‑D‑glucan synthase, blocking the synthesis of an essential cell‑wall component. This weakens the fungal cell wall, leading to cell lysis and death while sparing human cells.

The prescribed dose of Micafungin Accord is determined by the treating physician based on the specific infection, patient weight, renal and hepatic function, and clinical guidelines. No standard dosing is provided here.

Safety data for micafungin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and necessary import documentation.

Micafungin belongs to the echinocandin class, which targets the fungal cell wall, unlike azoles that inhibit ergosterol synthesis. Echinocandins generally have a favorable safety profile and are effective against many Candida species, including those resistant to azoles, but they are administered intravenously.

Micafungin Accord should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability.

Micafungin Accord is given by intravenous infusion. The infusion rate and duration are set by the prescribing clinician, typically over a period of 30‑60 minutes, and the medication is administered in a clinical setting with appropriate monitoring.

Serious risks include severe allergic reactions such as anaphylaxis, significant liver injury that may present with jaundice, and marked hypotension during infusion. Prompt medical attention is required if any of these events occur.

Patients with a known hypersensitivity to micafungin or any component of the formulation should avoid its use. Caution is also advised for individuals with severe hepatic impairment, and the drug should only be used under specialist supervision in pediatric patients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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