Product image of Micafungin Pharmazac 100 Mg (Micafungin) supplied by GNH India

Micafungin Pharmazac 100 Mg

Active Ingredient:
Micafungin
Origin:
EU

Micafungin Pharmazac 100 Mg (Micafungin)

Micafungin, the active ingredient in Micafungin Pharmazac 100 Mg, is an echinocandin presented as a 100 mg injectable solution for intravenous use. It treats invasive candidiasis and related fungal infections in immunocompromised patients.

GNH India supplies Micafungin Pharmazac 100 Mg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Pharmazac Sa

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Indications & Clinical Uses

Micafungin is an echinocandin antifungal used to treat serious Candida infections.

  • Invasive candidiasis: effective for bloodstream and deep‑tissue Candida infections.
  • Esophageal candidiasis: clears fungal infection of the esophagus.
  • Prophylaxis in hematopoietic stem cell transplantation: prevents Candida infection in transplant recipients.
  • Candida peritonitis and intra‑abdominal infections: treats intra‑abdominal Candida infections.

How It Works

  • Micafungin inhibits the enzyme β‑1,3‑D‑glucan synthase, which is essential for the synthesis of 1,3‑β‑D‑glucan, a critical component of the fungal cell wall. By blocking this pathway, the drug weakens the cell wall, leading to osmotic instability and fungal cell lysis, while having minimal effect on human cells.

Side Effects

Micafungin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Fever: transient elevation of body temperature.
  • Nausea: mild to moderate upset stomach.
  • Headache: occasional mild headache.
  • Elevated liver enzymes: mild increase in ALT/AST.
  • Phlebitis at infusion site: irritation or inflammation.

Serious or Rare Side Effects

  • Hepatotoxicity: significant liver injury.
  • Severe hypersensitivity: rash, angioedema, or anaphylaxis.
  • Renal impairment: acute kidney injury.
  • Neutropenia: marked reduction in neutrophil count.

Precautions & Warnings

When using Micafungin, clinicians should consider several safety and handling precautions.

  • Renal function: assess baseline kidney function before therapy.
  • Hepatic function: monitor liver enzymes during treatment.
  • Drug interactions: review concomitant medications for potential interactions.
  • Pregnancy: avoid use unless benefits outweigh potential risks, as safety is unknown.
  • Infusion reactions: monitor patient during IV administration for signs of reaction.
  • Store at 2-8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Micafungin can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Cyclosporine: increased micafungin exposure may raise toxicity risk.
  • Rifampin: may reduce micafungin plasma levels, decreasing effectiveness.

Moderate Interactions (Monitor Closely)

  • Azole antifungals (e.g., fluconazole): may alter micafungin metabolism.
  • Statins (e.g., simvastatin): potential for increased statin levels.
  • Immunosuppressants (e.g., tacrolimus): monitor levels due to possible changes.

Frequently Asked Questions

Micafungin Pharmazac 100 Mg is an intravenous echinocandin antifungal indicated for the treatment of invasive candidiasis, esophageal candidiasis, prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation, and Candida peritonitis or intra‑abdominal infections.

Micafungin blocks the enzyme β‑1,3‑D‑glucan synthase, preventing the synthesis of 1,3‑β‑D‑glucan, an essential component of the fungal cell wall. This disruption weakens the wall, causing osmotic instability and leading to fungal cell death while sparing human cells.

The appropriate dose of Micafungin Pharmazac 100 Mg is determined by the prescribing clinician based on the specific infection, patient weight, renal and hepatic function, and treatment guidelines. Dosage regimens are individualized and should follow the prescriber’s order.

Safety data for Micafungin in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. It should only be used when the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To place an order, submit an enquiry on the Micafungin Pharmazac 100 Mg product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Micafungin belongs to the echinocandin class, which targets the fungal cell wall, whereas azoles inhibit ergosterol synthesis and polyenes bind to membrane sterols. Echinocandins like Micafungin are generally well‑tolerated, have a low potential for drug‑drug interactions, and are effective against many Candida species, including those resistant to azoles.

Micafungin Pharmazac 100 Mg must be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. If temperature excursions occur, discard the product according to local regulations.

The product is supplied as a sterile injectable solution for intravenous infusion. It is administered by a healthcare professional through a peripheral or central line, typically over a 30‑ to 60‑minute infusion period, following the dosing instructions provided by the prescriber.

Serious adverse events include hepatotoxicity (significant liver enzyme elevations or liver failure), severe hypersensitivity reactions such as anaphylaxis, renal impairment, and neutropenia. Patients should be monitored regularly for liver function, renal parameters, and signs of allergic reactions during therapy.

Micafungin is contraindicated in patients with known hypersensitivity to Micafungin or any component of the formulation. Caution is advised for individuals with pre‑existing severe liver disease, uncontrolled renal impairment, or those receiving interacting medications that cannot be adjusted.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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