Product image of Micafungin Pharmazac, 100 Mg (Micafungin) supplied by GNH India

Micafungin Pharmazac, 100 Mg

Active Ingredient:
Micafungin
Origin:
EU

Micafungin Pharmazac, 100 Mg (Micafungin)

Micafungin, the active ingredient in Micafungin Pharmazac, 100 Mg, is an echinocandin presented as a 100 mg injection for intravenous use. It treats invasive candidiasis, esophageal candidiasis and is used for prophylaxis of Candida infections in hematopoietic stem cell transplantation patients.

GNH India supplies Micafungin Pharmazac, 100 mg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pharmazac Sa

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Indications & Clinical Uses

Micafungin is an echinocandin antifungal that targets invasive Candida infections.

  • Invasive candidiasis: effective treatment of bloodstream and deep‑tissue Candida infections.
  • Esophageal candidiasis: resolves fungal infection of the esophagus in immunocompromised patients.
  • Prophylaxis in hematopoietic stem cell transplantation: prevents Candida infection during transplant conditioning.

How It Works

  • Micafungin inhibits the enzyme β‑(1,3)‑D‑glucan synthase, blocking synthesis of β‑(1,3)‑D‑glucan, a vital component of the fungal cell wall. This disruption weakens the wall, causing osmotic instability and cell lysis. The drug is fungicidal against most Candida species and fungistatic against Aspergillus, providing selective antifungal activity while sparing human cells.

Side Effects

Micafungin may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Fever: transient elevation of body temperature.
  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: occasional mild headache.
  • Elevated liver enzymes: mild increase in ALT/AST.
  • Rash: mild skin erythema.

Serious or Rare Side Effects

  • Hepatotoxicity: significant liver injury requiring monitoring.
  • Severe hypersensitivity: anaphylaxis or angioedema.
  • Infusion‑related reactions: hypotension or bronchospasm.
  • Nephrotoxicity: rare renal impairment.
  • Thrombocytopenia: low platelet count.

Precautions & Warnings

When using Micafungin, several precautions should be observed to ensure patient safety and product integrity.

  • Liver function monitoring: assess baseline and periodic ALT/AST levels.
  • Renal function assessment: evaluate creatinine clearance before and during therapy.
  • Drug interactions: review concomitant medications for potential CYP interactions.
  • Pregnancy and lactation: avoid use unless benefits outweigh unknown risks.
  • Hypersensitivity history: discontinue if signs of severe allergic reaction appear.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Micafungin can interact with other medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Cyclosporine: increased micafungin exposure may raise toxicity risk.
  • Rifampin: strong enzyme induction may reduce micafungin levels.

Moderate Interactions (Monitor Closely)

  • Azole antifungals (e.g., fluconazole): may alter plasma concentrations.
  • Warfarin: potential effect on anticoagulation parameters.
  • Immunosuppressants (e.g., tacrolimus): monitor drug levels.

Frequently Asked Questions

Micafungin Pharmazac, 100 mg is an intravenous echinocandin antifungal indicated for the treatment of invasive candidiasis, esophageal candidiasis, and for prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation. It is administered under the direction of a qualified healthcare professional in hospital or clinic settings.

Micafungin inhibits the enzyme β‑(1,3)‑D‑glucan synthase, blocking the synthesis of β‑(1,3)‑D‑glucan, a vital component of the fungal cell wall. This disruption compromises cell wall integrity, leading to osmotic instability and fungal cell death, providing a targeted antifungal effect with limited impact on human cells.

The specific dose of Micafungin Pharmazac, 100 mg is determined by the prescribing clinician based on the patient’s infection type, severity, weight, renal and hepatic function, and other clinical factors. Healthcare providers follow approved guidelines and adjust the regimen as needed for each individual case.

The safety of Micafungin in pregnancy and lactation has not been established; it is classified as pregnancy category unknown. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details—including cold‑chain handling if needed—and assists with import documentation.

Compared with azole antifungals, micafungin belongs to the echinocandin class and targets the fungal cell wall rather than ergosterol synthesis, offering a different safety profile and activity against many azole‑resistant Candida species. Unlike polyenes, it has lower nephrotoxicity, making it a valuable option for patients with renal concerns.

Micafungin Pharmazac, 100 mg should be stored at 2 °C to 8 °C (refrigerated). Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the product. Maintaining the cold chain preserves drug stability and potency until the time of administration.

The medication is supplied as a sterile powder for injection that must be reconstituted with the appropriate diluent and administered intravenously over a specified infusion period. Administration is performed by qualified healthcare personnel in a clinical setting, following aseptic technique and the prescribing information for infusion rate and monitoring.

The most serious risks include hepatotoxicity, severe hypersensitivity reactions such as anaphylaxis, and rare infusion‑related events like hypotension or bronchospasm. Patients should be monitored for signs of liver dysfunction, allergic response, and hemodynamic changes during and after the infusion, and therapy should be discontinued if serious adverse events occur.

Micafungin is contraindicated in patients with a known hypersensitivity to micafungin or any component of the formulation. Caution is also advised for individuals with pre‑existing severe liver disease, and it should be avoided in pregnant or breastfeeding women unless the clinical benefit justifies potential risks. Clinical judgment determines suitability.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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