Product image of Micafungin Pharmazac 50 Mg (Micafungin) supplied by GNH India

Micafungin Pharmazac 50 Mg

Active Ingredient:
Micafungin
Origin:
EU

Micafungin Pharmazac 50 Mg (Micafungin)

Micafungin, the active ingredient in Micafungin Pharmazac 50 Mg, is an echinocandin presented as a 50 mg injectable solution for intravenous use. It treats invasive candidiasis, esophageal candidiasis, Candida peritonitis and is used for prophylaxis of Candida infections in hematopoietic stem cell transplant recipients. It is indicated for adult and pediatric patients with confirmed infections.

GNH India supplies Micafungin Pharmazac 50 Mg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation.

Manufacturer / TM Owner

Pharmazac Sa

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Indications & Clinical Uses

  • Micafungin is an echinocandin antifungal used to treat serious Candida infections.
  • Invasive candidiasis: eradicates bloodstream Candida species in immunocompromised patients.
  • Esophageal candidiasis: clears fungal infection of the esophageal mucosa.
  • Candida peritonitis and intra‑abdominal infections: resolves deep-seated intra‑abdominal Candida disease.
  • Prophylaxis of Candida infections in hematopoietic stem cell transplant recipients: prevents invasive candidiasis in high‑risk transplant patients.

How It Works

  • Micafungin inhibits the fungal enzyme β‑(1,3)‑D‑glucan synthase, which is essential for synthesis of β‑(1,3)‑D‑glucan, a critical component of the fungal cell wall. By blocking this pathway, the drug weakens the cell wall, leading to osmotic instability and cell lysis, while having minimal effect on human cells because they lack this enzyme.

Side Effects

Micafungin may be associated with a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Fever: transient elevation of body temperature.
  • Nausea: mild gastrointestinal upset.
  • Headache: mild to moderate pain.
  • Elevated liver enzymes: mild increase in transaminases.

Serious or Rare Side Effects

  • Hepatotoxicity: significant liver injury.
  • Severe hypersensitivity reactions: anaphylaxis, rash.
  • Infusion‑related reactions: hypotension, bronchospasm.

Precautions & Warnings

Use of Micafungin requires careful clinical assessment and monitoring.

  • Renal impairment: adjust monitoring as micafungin is primarily hepatic cleared.
  • Hepatic dysfunction: use with caution; monitor liver function tests.
  • Concomitant strong CYP3A4 inducers: may reduce exposure.
  • Pregnancy: safety not established; weigh benefits vs risks.
  • Pediatric use: safety and efficacy established for certain age groups; follow prescribing info.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Micafungin can interact with several drug classes, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly reduce micafungin plasma levels.
  • Co‑administration with other echinocandins: increased risk of hepatotoxicity.

Moderate Interactions (Monitor Closely)

  • Azole antifungals (e.g., fluconazole, voriconazole): may increase micafungin exposure.
  • Immunosuppressants (e.g., cyclosporine, tacrolimus): monitor levels for potential increase.
  • Warfarin: may enhance anticoagulant effect; monitor INR.

Frequently Asked Questions

Micafungin Pharmazac 50 mg is an intravenous echinocandin antifungal indicated for the treatment of invasive candidiasis, esophageal candidiasis, Candida peritonitis and intra‑abdominal infections, and for prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation.

Micafungin blocks the fungal enzyme β‑(1,3)‑D‑glucan synthase, preventing the synthesis of β‑(1,3)‑D‑glucan, an essential component of the fungal cell wall. This disruption weakens the wall, causing osmotic instability and cell death, while human cells are unaffected because they lack this enzyme.

The specific dose and duration of Micafungin Pharmazac 50 mg are determined by the prescribing clinician based on the infection type, severity, patient weight, renal and hepatic function, and other clinical factors. No standard dosing regimen is provided here.

Safety data for micafungin in pregnancy and lactation are limited, and the product is classified as pregnancy category unknown. Use is only recommended when the potential benefit justifies any potential risk to the fetus or infant, and decisions should be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Micafungin belongs to the echinocandin class, which targets the fungal cell wall, whereas azoles inhibit ergosterol synthesis and polyenes bind directly to membrane sterols. Echinocandins like micafungin are generally well‑tolerated, have minimal drug‑drug interactions, and are effective against many Candida species, including some azole‑resistant strains.

The product should be stored refrigerated at 2 °C to 8 °C. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. If the solution must be administered, allow it to reach room temperature before use, following aseptic technique.

Micafungin Pharmazac 50 mg is supplied as an injectable solution for intravenous infusion. It is administered by a healthcare professional through a peripheral or central line, typically over a period of 30 to 60 minutes, according to the prescriber's instructions and institutional protocols.

Serious adverse events include hepatotoxicity (significant liver enzyme elevation or liver failure), severe hypersensitivity reactions such as anaphylaxis, and infusion‑related reactions like hypotension or bronchospasm. Patients should be monitored for signs of liver dysfunction, rash, respiratory distress, or sudden blood pressure changes during and after infusion.

Micafungin is contraindicated in patients with a known hypersensitivity to micafungin or any component of the formulation. Caution is also advised for individuals with severe hepatic impairment, and it should be avoided in patients receiving other echinocandins or strong CYP3A4 inducers without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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