Product image of Micafungin Pharmazac, 50 Mg (Micafungin) supplied by GNH India

Micafungin Pharmazac, 50 Mg

Active Ingredient:
Micafungin
Origin:
EU

Micafungin Pharmazac, 50 Mg (Micafungin)

Micafungin, the active ingredient in Micafungin Pharmazac, 50 Mg, is an echinocandin presented as a 50 mg injectable solution for intravenous use. It treats invasive candidiasis, esophageal candidiasis, and is used for prophylaxis of Candida infections in hematopoietic stem cell transplantation.

GNH India supplies Micafungin Pharmazac, 50 Mg as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Pharmazac Sa

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Indications & Clinical Uses

  • Micafungin is an echinocandin antifungal that inhibits fungal cell wall synthesis.
  • Invasive candidiasis: effective treatment of bloodstream and deep‑seated Candida infections.
  • Esophageal candidiasis: resolves mucosal infection of the esophagus caused by Candida species.
  • Prophylaxis of Candida infections in hematopoietic stem cell transplantation: prevents invasive candidiasis in high‑risk transplant recipients.

How It Works

  • Micafungin binds to the fungal enzyme β‑(1,3)‑D‑glucan synthase, blocking the polymerization of β‑(1,3)‑D‑glucan, an essential structural component of the fungal cell wall. Inhibition weakens the cell wall, leading to osmotic instability and cell lysis, while human cells lack this pathway, providing selective antifungal activity.

Side Effects

Micafungin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Elevated liver enzymes: transient increase in ALT or AST.
  • Infusion‑related reactions: flushing, rash, or mild hypotension during administration.
  • Fever: mild to moderate temperature rise.
  • Nausea: occasional gastrointestinal discomfort.

Serious or Rare Side Effects

  • Severe hepatic dysfunction: marked elevation of liver enzymes or hepatitis.
  • Anaphylaxis: acute allergic reaction with respiratory distress or hypotension.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Renal impairment: acute kidney injury in susceptible patients.

Precautions & Warnings

When using Micafungin, clinicians should observe several safety measures.

  • Liver function monitoring: assess baseline and periodic ALT/AST levels.
  • Renal function assessment: evaluate creatinine clearance before and during therapy.
  • Drug interactions: review concomitant medications that affect hepatic metabolism.
  • Pregnancy and lactation: use only if benefit outweighs potential risk, as safety data are limited.
  • Patient selection: avoid in patients with known hypersensitivity to echinocandins.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Micafungin can interact with other medicines, requiring attention to the interaction strength.

Major Interactions (Avoid)

  • Cytochrome P450 inducers (e.g., rifampin, carbamazepine): may reduce micafungin exposure.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase micafungin levels, raising toxicity risk.
  • Concurrent use with other echinocandins: additive toxicity, not recommended.

Moderate Interactions (Monitor Closely)

  • Immunosuppressants (e.g., tacrolimus, cyclosporine): monitor drug levels as micafungin may affect metabolism.
  • Antifungal agents with overlapping toxicity (e.g., amphotericin B): watch for hepatic or renal adverse effects.
  • Concomitant use with warfarin: monitor INR as micafungin may alter anticoagulant effect.

Frequently Asked Questions

Micafungin Pharmazac, 50 Mg is indicated for the treatment of invasive candidiasis, esophageal candidiasis, and for prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation. These uses reflect its activity against a broad range of Candida species that cause serious systemic and mucosal infections.

Micafungin inhibits the fungal enzyme β‑(1,3)‑D‑glucan synthase, which is essential for synthesizing β‑(1,3)‑D‑glucan, a key structural component of the fungal cell wall. By blocking this pathway, the drug weakens the cell wall, leading to osmotic instability and fungal cell death while sparing human cells that lack this target.

The prescribed dose of Micafungin is determined by the treating clinician based on the specific infection, its severity, the patient’s renal and hepatic function, and any relevant clinical guidelines. Dosage adjustments may be required for special populations, but the exact regimen is set by the healthcare professional.

Safety data for Micafungin in pregnancy and lactation are limited, and the pregnancy category is listed as unknown. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by the prescribing physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then replies with pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Micafungin belongs to the echinocandin class, which targets the fungal cell wall, whereas azoles inhibit ergosterol synthesis in the cell membrane. Echinocandins like Micafungin are generally effective against azole‑resistant Candida strains and have a different safety profile, making them a valuable alternative or adjunct in resistant or severe infections.

Micafungin Pharmazac should be stored at 2‑8 °C (refrigerated). The product must be kept in its original container, protected from light, and should never be frozen or shaken. Maintaining the cold‑chain ensures stability and potency of the injectable solution.

Micafungin is given as an intravenous infusion. The solution is diluted according to the manufacturer’s instructions and administered over a period typically ranging from 30 to 60 minutes, depending on the clinical protocol and patient tolerance. Administration is performed by qualified healthcare personnel in a controlled setting.

The most serious adverse reactions include severe hepatic dysfunction (marked elevation of liver enzymes or hepatitis), anaphylactic or severe allergic reactions, and rare but life‑threatening skin conditions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Prompt recognition and medical intervention are essential if these events occur.

Micafungin should be avoided in patients with a known hypersensitivity to micafungin or any other echinocandin. Caution is also advised for individuals with pre‑existing severe liver disease, and the drug should be used only when the benefits outweigh the risks in pregnant or breastfeeding women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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