Product image of Micafungin Pharmore (Micafungin) supplied by GNH India

Micafungin Pharmore

Active Ingredient:
Micafungin
Origin:
EU

Micafungin Pharmore (Micafungin)

Micafungin, the active ingredient in Micafungin Pharmore, is an Echinocandin presented as an intravenous formulation for infusion use. It treats serious fungal infections such as invasive candidiasis and esophageal candidiasis, and is used for prophylaxis in patients undergoing hematopoietic stem cell transplantation.

GNH India supplies Micafungin Pharmore as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The product meets European market standards and is manufactured under strict quality controls.

Manufacturer / TM Owner

Pharmore Gmbh

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Indications & Clinical Uses

  • Micafungin is an antifungal agent indicated for several Candida‑related conditions.
  • Invasive candidiasis: effective treatment of bloodstream and deep‑tissue Candida infections.
  • Esophageal candidiasis: resolves mucosal infection and associated symptoms.
  • Prophylaxis in hematopoietic stem cell transplantation: prevents Candida infection during the high‑risk post‑transplant period.

How It Works

  • Micafungin inhibits the enzyme β‑(1,3)‑D‑glucan synthase, which is essential for synthesizing β‑(1,3)‑D‑glucan, a key structural component of the fungal cell wall. By blocking this pathway, the drug weakens the cell wall, leading to osmotic instability and cell lysis. The mechanism is selective for fungi, resulting in minimal impact on human cells.

Side Effects

Micafungin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Infusion‑related reactions: flushing, erythema, or pruritus at the infusion site.
  • Gastrointestinal disturbances: nausea, vomiting, or abdominal pain.
  • Elevated liver enzymes: transient increase in ALT or AST.
  • Fever: mild to moderate temperature rise.

Serious or Rare Side Effects

  • Hypersensitivity reactions: anaphylaxis, angioedema, or severe rash.
  • Hepatotoxicity: marked elevation of liver transaminases or bilirubin.
  • Renal impairment: acute kidney injury or increased serum creatinine.
  • Severe neutropenia: marked reduction in white blood cell count.

Precautions & Warnings

  • When using Micafungin, clinicians should observe several safety considerations.
  • Renal function: monitor serum creatinine and urine output during therapy.
  • Hepatic function: check liver enzymes before and periodically during treatment.
  • Infusion reactions: be prepared to manage hypotension, rash, or bronchospasm.
  • Concomitant nephrotoxic agents: use with caution and adjust dosing if needed.
  • Pregnancy and lactation: avoid unless benefit outweighs potential risk.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Micafungin can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly reduce micafungin exposure.
  • Azole antifungals (e.g., fluconazole, itraconazole): may increase micafungin levels and risk of toxicity.
  • Immunosuppressants (e.g., tacrolimus, cyclosporine): may raise drug concentrations, requiring dose adjustment.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inducers (e.g., phenobarbital): may lower micafungin concentrations.
  • Warfarin: monitor INR as micafungin may affect anticoagulant effect.
  • Concurrent use of other antifungals: assess for additive toxicity.

Frequently Asked Questions

Micafungin Pharmore is an intravenous antifungal medication indicated for the treatment of invasive candidiasis, esophageal candidiasis, and for prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation. It targets serious fungal infections where rapid and effective eradication is required.

Micafungin works by inhibiting the fungal enzyme β‑(1,3)‑D‑glucan synthase, which is essential for producing β‑(1,3)‑D‑glucan, a critical component of the fungal cell wall. Disruption of cell‑wall synthesis leads to osmotic instability, cell lysis, and ultimately eradication of the fungus.

The dosing regimen for Micafungin Pharmore is determined by the prescribing clinician based on the specific indication, patient weight, renal and hepatic function, and other clinical factors. Healthcare professionals set the appropriate dose and infusion rate for each individual case.

The safety of Micafungin during pregnancy and lactation has not been definitively established. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Micafungin Pharmore product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Micafungin belongs to the echinocandin class, which differs from azole antifungals by targeting the fungal cell wall rather than ergosterol synthesis. Echinocandins, including Micafungin, generally have a favorable safety profile and are effective against many azole‑resistant Candida species, making them a valuable alternative when azoles are unsuitable.

Micafungin Pharmore should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. The product should remain in its original packaging until preparation for infusion to maintain stability and potency.

Micafungin is given by intravenous infusion. The reconstituted solution is administered over a prescribed period, typically ranging from 30 to 60 minutes, depending on the clinical protocol and patient tolerance. Infusion should be performed by qualified healthcare personnel in a controlled setting.

Serious adverse events include hypersensitivity reactions such as anaphylaxis, significant liver enzyme elevations indicating hepatotoxicity, acute renal impairment, and severe neutropenia. Patients should be monitored closely for signs of allergic response, liver dysfunction, or sudden changes in kidney function during therapy.

Micafungin is contraindicated in patients with known hypersensitivity to Micafungin or any component of the formulation. Caution is also advised for individuals with severe hepatic impairment, uncontrolled renal failure, or those receiving interacting medications that could lead to toxic drug levels.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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