Product image of Micafungin Teva (Micafungin) supplied by GNH India

Micafungin Teva

Active Ingredient:
Micafungin
Origin:
EU

Micafungin Teva (Micafungin)

Micafungin, the active ingredient in Micafungin Teva, is an echinocandin presented as a intravenous solution for intravenous use. It treats invasive candidiasis, esophageal candidiasis, and is used for Candida prophylaxis in hematopoietic stem cell transplantation.
GNH India supplies Micafungin Teva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Micafungin is an echinocandin antifungal used to treat serious Candida infections.

  • Invasive candidiasis: effective for bloodstream and deep‑tissue Candida infections.
  • Esophageal candidiasis: clears fungal infection of the esophagus.
  • Candida prophylaxis in hematopoietic stem cell transplantation: prevents invasive Candida disease in transplant recipients.

How It Works

  • Micafungin inhibits the enzyme β-(1,3)-D-glucan synthase, which is essential for synthesizing β-(1,3)-D-glucan, a key structural component of the fungal cell wall. This inhibition weakens the cell wall, leading to osmotic instability and fungal cell death, providing a fungicidal effect against susceptible Candida species.

Side Effects

Micafungin may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Fever: transient elevation of body temperature.
  • Nausea: mild to moderate upset stomach.
  • Headache: occasional mild headache.
  • Elevated liver enzymes: mild increase in ALT/AST.

Serious or Rare Side Effects

  • Hepatotoxicity: significant liver injury with jaundice.
  • Severe hypersensitivity: anaphylaxis or extensive skin rash.
  • Infusion‑related reactions: hypotension, dyspnea, or chest pain.

Precautions & Warnings

Before using Micafungin, consider the following precautions.

  • Renal impairment: monitor kidney function in patients with reduced clearance.
  • Hepatic dysfunction: assess liver enzymes prior to therapy.
  • Concomitant azoles: avoid co‑administration with strong CYP3A4 inhibitors.
  • Pregnancy: use only if potential benefit justifies risk; data limited.
  • Pediatric use: safety not established in children under 1 month.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Micafungin can interact with other medicines; key interactions are:

Major Interactions (Avoid)

  • Cyclosporine: increased micafungin exposure; may require dose adjustment.
  • Rifampin: reduced micafungin levels; may diminish efficacy.
  • Strong CYP3A4 inducers (e.g., carbamazepine): lower micafungin concentrations.

Moderate Interactions (Monitor Closely)

  • Azole antifungals (e.g., fluconazole): potential additive hepatotoxicity.
  • Warfarin: monitor INR as micafungin may affect anticoagulation.
  • Immunosuppressants (e.g., tacrolimus): observe drug levels for possible changes.

Frequently Asked Questions

Micafungin Teva is indicated for the treatment of invasive candidiasis, esophageal candidiasis, and for Candida prophylaxis in patients undergoing hematopoietic stem cell transplantation. It is an antifungal agent that targets serious Candida infections in immunocompromised or high‑risk patients.

Micafungin inhibits the fungal enzyme β-(1,3)-D-glucan synthase, which is required for the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall. By disrupting cell‑wall formation, the drug causes osmotic instability and leads to fungal cell death.

The dosage of Micafungin Teva is determined by the prescribing healthcare professional based on the specific indication, patient weight, renal and hepatic function, and other clinical factors. Only a qualified prescriber should set the appropriate dosing regimen.

Safety data for micafungin in pregnancy and lactation are limited. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by the treating physician.

To order Micafungin Teva, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Micafungin belongs to the echinocandin class, which differs from azole antifungals such as fluconazole. Echinocandins target the fungal cell wall, offering a fungicidal effect and a lower risk of drug‑drug interactions with CYP enzymes, whereas azoles inhibit ergosterol synthesis and may have more extensive hepatic metabolism and interaction profiles.

Micafungin Teva should be stored at 2‑8 °C (refrigerated). Keep the solution in its original container, protect it from light, and avoid freezing or shaking. If the product must be transported, maintain the cold‑chain conditions throughout the journey.

Micafungin is given as an intravenous infusion. The infusion is typically administered over a period of 30‑60 minutes, depending on the clinical protocol and patient tolerance. Administration should be performed by qualified healthcare personnel in a setting equipped for IV therapy.

The most serious adverse events include hepatotoxicity (significant liver injury), severe hypersensitivity reactions such as anaphylaxis, and infusion‑related reactions that may cause hypotension, respiratory distress, or chest pain. Patients should be monitored closely for these events during and after infusion.

Micafungin is contraindicated in individuals with a known hypersensitivity to micafungin or any component of the formulation. Caution is also advised for patients with severe hepatic impairment, as liver dysfunction may increase the risk of toxicity. The drug should be avoided in such cases unless the prescriber determines that benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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