Product image of Micafungin Teva (Micafungin) supplied by GNH India

Micafungin Teva

Active Ingredient:
Micafungin
Origin:
EU

Micafungin Teva (Micafungin)

Micafungin, the active ingredient in Micafungin Teva, is an echinocandin antifungal presented as an intravenous solution for intravenous use. It treats invasive candidiasis, esophageal candidiasis and is used for prophylaxis of Candida infections in hematopoietic stem cell transplantation.

GNH India supplies Micafungin Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and oncology centres worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Micafungin is an echinocandin antifungal that inhibits fungal cell wall synthesis.
  • Invasive candidiasis: effective treatment of bloodstream and deep‑tissue Candida infections.
  • Esophageal candidiasis: resolves Candida infection of the esophagus.
  • Prophylaxis in hematopoietic stem cell transplantation: prevents Candida infections in transplant recipients.

How It Works

  • Micafungin binds to and inhibits the enzyme β‑(1,3)‑D‑glucan synthase, which is essential for the synthesis of β‑(1,3)‑D‑glucan, a critical component of the fungal cell wall. By disrupting cell wall formation, the drug leads to osmotic instability and fungal cell death, while having minimal effect on human cells that lack this pathway.

Side Effects

Common Side Effects

  • Fever or chills during infusion
  • Nausea or vomiting
  • Headache
  • Infusion‑related erythema or rash
  • Elevated liver enzymes (ALT, AST)
  • Mild hypotension

Serious or Rare Side Effects

  • Severe hepatic dysfunction or hepatitis
  • Anaphylactic or severe allergic reactions
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Severe hypotension or shock
  • Acute renal failure
  • Cardiac arrhythmias

Precautions & Warnings

  • Micafungin should be used with careful clinical monitoring.
  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hepatic dysfunction: assess liver enzymes before and during treatment.
  • Concomitant azole therapy: evaluate for potential pharmacokinetic interactions.
  • Pregnancy: safety not established; use only if benefit outweighs risk.
  • Breastfeeding: unknown excretion; consider risk to infant.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Micafungin may interact with several drug classes.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin) may reduce micafungin exposure.
  • CYP3A4 inhibitors (e.g., ketoconazole) may increase micafungin levels.
  • Co‑administration with other echinocandins can increase toxicity risk.

Moderate Interactions (Monitor Closely)

  • Concurrent use with warfarin may affect INR; monitor coagulation.
  • Immunosuppressants such as cyclosporine may require dose adjustment.
  • Drugs that prolong QT interval may need cardiac monitoring.

Frequently Asked Questions

Micafungin Teva is an intravenous formulation of the echinocandin antifungal micafungin. It is indicated for the treatment of invasive candidiasis, esophageal candidiasis, and for prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation.

Micafungin inhibits the fungal enzyme β‑(1,3)‑D‑glucan synthase, which is required for synthesis of β‑(1,3)‑D‑glucan, an essential component of the fungal cell wall. Disruption of cell‑wall formation leads to osmotic instability and fungal cell death.

The dosage of Micafungin Teva is determined by the prescribing clinician based on the specific indication, severity of infection, patient weight, renal and hepatic function, and other clinical factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of micafungin during pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To order Micafungin Teva, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Micafungin belongs to the echinocandin class, which targets the fungal cell wall, unlike azoles that inhibit ergosterol synthesis or polyenes that bind membrane sterols. Echinocandins generally have a favorable safety profile and are effective against many Candida species, including some azole‑resistant strains.

Micafungin Teva should be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and do not freeze or shake the solution. Once reconstituted, use according to the manufacturer’s stability guidelines.

Micafungin is administered by intravenous infusion, typically over 60 minutes. The infusion rate and duration are determined by the prescriber based on the indication and patient tolerance. Administration should be performed by qualified healthcare personnel in a clinical setting.

Serious adverse events include severe hepatic dysfunction, anaphylactic reactions, Stevens‑Johnson syndrome or toxic epidermal necrolysis, marked hypotension, acute renal failure, and cardiac arrhythmias. Patients should be monitored for signs of liver injury, allergic reactions, and hemodynamic changes during and after infusion.

Micafungin is contraindicated in individuals with a known hypersensitivity to micafungin or any component of the formulation. Caution is advised in patients with severe hepatic impairment, and it should be avoided in those with a history of severe allergic reactions to echinocandins.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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