Product image of Micafungin Teva (Micafungin Sodium) supplied by GNH India

Micafungin Teva

Active Ingredient:
Micafungin Sodium
Origin:
EU

Micafungin Teva (Micafungin Sodium)

Micafungin, the active ingredient in Micafungin Teva, is an echinocandin presented as an injection for intravenous use. It treats invasive fungal infections such as candidiasis in immunocompromised patients, including those undergoing chemotherapy or stem‑cell transplantation.

GNH India supplies Micafungin Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Micafungin is an echinocandin antifungal used to treat serious fungal infections.

  • Invasive candidiasis: effective treatment of bloodstream and deep‑tissue Candida infections.
  • Esophageal candidiasis: eradicates Candida infection of the esophagus in adults.
  • Prophylaxis of fungal infections in hematopoietic stem cell transplantation: prevents invasive candidiasis during the transplant period.
  • Febrile neutropenia: empirical therapy for suspected fungal infection in neutropenic patients.

How It Works

  • Micafungin inhibits the enzyme β‑(1,3)‑D‑glucan synthase, which is essential for the synthesis of β‑(1,3)‑D‑glucan, a critical component of the fungal cell wall. By disrupting cell‑wall integrity, the drug leads to osmotic instability and fungal cell death, while having minimal effect on human cells that lack this pathway.

Side Effects

Micafungin may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Fever: transient temperature rise during infusion.
  • Nausea: mild gastrointestinal upset.
  • Headache: occasional mild to moderate headache.
  • Elevated liver enzymes: transient increase in ALT or AST.

Serious or Rare Side Effects

  • Severe hepatic failure: rare but may require discontinuation.
  • Anaphylaxis: acute hypersensitivity reaction with rash, bronchospasm, or hypotension.
  • Stevens‑Johnson syndrome: severe skin reaction requiring urgent care.

Precautions & Warnings

Use micafungin with careful clinical monitoring and consider patient‑specific factors.

  • Liver function monitoring: assess baseline and periodic liver enzymes.
  • Renal function assessment: evaluate creatinine clearance before initiation.
  • Hypersensitivity caution: discontinue if signs of allergic reaction appear.
  • Hepatic impairment dose adjustment: consider reduced exposure in severe liver disease.
  • Storage: Store at 2‑8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Micafungin can interact with several co‑administered medicines; clinical judgment is required.

Major Interactions (Avoid)

  • Cyclosporine: increased micafungin exposure may raise toxicity risk.
  • Rifampin: strong enzyme induction can markedly reduce micafungin levels.

Moderate Interactions (Monitor Closely)

  • Azole antifungals (e.g., fluconazole): potential additive hepatotoxicity.
  • Statins (e.g., simvastatin): monitor liver function tests.
  • Immunosuppressants (e.g., tacrolimus): observe for altered drug concentrations.

Frequently Asked Questions

Micafungin Teva is indicated for the treatment of invasive candidiasis, esophageal candidiasis, and for prophylaxis of fungal infections in patients undergoing hematopoietic stem cell transplantation. It is also employed in the management of suspected fungal infection during febrile neutropenia.

Micafungin inhibits the fungal enzyme β‑(1,3)‑D‑glucan synthase, which is essential for building β‑(1,3)‑D‑glucan, a key structural component of the fungal cell wall. Disruption of cell‑wall synthesis leads to osmotic instability and cell death, while human cells are largely unaffected because they lack this pathway.

The specific dose of Micafungin Teva is determined by the prescribing clinician based on the patient’s condition, weight, renal and hepatic function, and the indication being treated. Healthcare professionals follow established guidelines and adjust the regimen as needed for safety and efficacy.

The safety of Micafungin Teva in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by the treating physician after a careful risk‑benefit assessment.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and necessary import documentation.

Micafungin belongs to the echinocandin class, which targets the fungal cell wall, whereas azoles inhibit ergosterol synthesis and polyenes bind directly to membrane sterols. Echinocandins like micafungin generally have a favorable safety profile and are effective against many Candida species, including those resistant to azoles.

Micafungin Teva should be stored at 2‑8 °C in a refrigerator. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside this range.

Micafungin Teva is administered intravenously. The infusion is given over a period of usually 60 minutes, using a sterile diluent as recommended by the manufacturer. Administration should be performed by qualified healthcare personnel in a clinical setting.

Serious risks include severe hepatic dysfunction, anaphylactic reactions, and rare skin disorders such as Stevens‑Johnson syndrome. Patients should be monitored for signs of liver injury, hypersensitivity, and any unusual skin changes, and the drug should be discontinued promptly if these events occur.

Micafungin Teva is contraindicated in patients with a known hypersensitivity to micafungin or any component of the formulation. Caution is also advised for individuals with severe hepatic impairment, as well as those receiving interacting medications that could increase toxicity.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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