Product image of Micafungina Teva (Micafungin) supplied by GNH India

Micafungina Teva

Active Ingredient:
Micafungin
Origin:
EU

Micafungina Teva (Micafungin)

Micafungin, the active ingredient in Micafungina Teva, is an echinocandin presented as an injection for intravenous use. It treats invasive fungal infections such as candidemia, esophageal candidiasis and provides prophylaxis against aspergillosis in immunocompromised patients.

GNH India supplies Micafungina Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution. Clients benefit from reliable logistics, cold‑chain management and comprehensive documentation to meet import requirements.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

  • Micafungin is used to treat and prevent invasive fungal infections by targeting the cell wall of susceptible Candida and Aspergillus species.
  • Invasive candidiasis: effective treatment of bloodstream and deep‑tissue Candida infections in adult and pediatric patients.
  • Candida esophagitis: promotes healing of esophageal infection caused by Candida species.
  • Febrile neutropenia: used as empirical therapy for fever in neutropenic patients at risk of invasive fungal disease.
  • Prophylaxis of invasive aspergillosis: administered to high‑risk patients to prevent Aspergillus infection.

How It Works

  • Micafungin inhibits the enzyme β‑(1,3)‑D‑glucan synthase, which is essential for synthesizing β‑(1,3)‑D‑glucan, a critical component of the fungal cell wall. By blocking this pathway, the drug weakens the cell wall, leading to osmotic instability and fungal cell lysis, while having minimal effect on human cells that lack this polymer. The inhibition is dose‑dependent and results in rapid fungicidal activity against most Candida species and Aspergillus spp.

Side Effects

Micafungin may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Fever
  • Nausea
  • Elevated liver enzymes (ALT, AST)

Serious or Rare Side Effects

  • Severe hepatic failure
  • Anaphylactic or severe hypersensitivity reactions
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis

Precautions & Warnings

When using Micafungina Teva, clinicians should observe several safety considerations to minimize risk.

  • Monitor liver function: assess ALT/AST levels before and during therapy.
  • Assess renal function: evaluate serum creatinine and adjust if impairment present.
  • Use caution in patients with known hypersensitivity to echinocandins.
  • Avoid use in severe hepatic impairment unless benefits outweigh risks.
  • Review concomitant medications for potential interactions.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Micafungin can interact with other medicines; some combinations require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Rifampin or other strong CYP3A4 inducers: may markedly reduce micafungin exposure.
  • Co‑administration with other echinocandins: provides no added benefit and increases toxicity risk.

Moderate Interactions (Monitor Closely)

  • Azole antifungals (e.g., fluconazole, voriconazole): may increase micafungin plasma levels.
  • Immunosuppressants (e.g., tacrolimus, cyclosporine): monitor drug concentrations.
  • Warfarin: observe INR for possible alteration.
  • Statins (e.g., simvastatin): watch for signs of myopathy.

Frequently Asked Questions

Micafungina Teva is indicated for the treatment of invasive candidiasis, Candida esophagitis, and febrile neutropenia, as well as for prophylaxis of invasive aspergillosis in patients at high risk, such as those undergoing chemotherapy or stem‑cell transplantation.

Micafungin blocks the fungal enzyme β‑(1,3)‑D‑glucan synthase, preventing synthesis of β‑(1,3)‑D‑glucan, an essential structural component of the fungal cell wall. This disruption weakens the wall, causing osmotic instability and cell death while sparing human cells that lack this polymer.

The prescribed dose of Micafungina Teva is individualized by the treating physician based on the specific indication, patient weight, renal and hepatic function, and severity of infection. Dosing regimens are outlined in the product label and should not be altered without medical guidance.

Safety data for micafungin in pregnancy and lactation are limited. The product is classified as pregnancy category unknown, and the decision to use it should be based on a risk‑benefit assessment by the prescriber. Breastfeeding mothers should consult their healthcare provider before use.

To place an order, submit an enquiry on the Micafungina Teva product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and import documentation.

Micafungina Teva belongs to the echinocandin class, which targets the fungal cell wall, whereas azoles inhibit ergosterol synthesis and polyenes bind to membrane sterols. Echinocandins generally have a favorable safety profile, limited drug‑drug interactions, and are fungicidal against most Candida species, making them a preferred option for certain invasive infections.

Micafungina Teva should be stored at 2‑8 °C (refrigerated). Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking. If the product must be transported, maintain the cold‑chain throughout to preserve stability and potency.

Micafungina Teva is supplied as a sterile powder for reconstitution and is administered by intravenous infusion. The reconstituted solution is infused over a period specified by the prescribing information, typically 30‑60 minutes, under aseptic conditions in a clinical setting.

Serious adverse events include severe hepatic failure, anaphylactic or severe hypersensitivity reactions, and rare skin disorders such as Stevens‑Johnson syndrome or toxic epidermal necrolysis. Prompt recognition and discontinuation of therapy are essential if any of these reactions occur.

Patients with a known hypersensitivity to micafungin or any component of the formulation should avoid its use. Caution is also advised for individuals with severe hepatic impairment, and the drug should be used only when the potential benefit outweighs the risk in such cases.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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