Product image of Miclodin (Clotrimazole) supplied by GNH India

Miclodin

Active Ingredient:
Clotrimazole
Origin:
EU

Miclodin (Clotrimazole)

Clotrimazole, the active ingredient in Miclodin, is an imidazole antifungal presented as a vaginal formulation for vaginal use. It treats vaginal candidiasis and other vaginal fungal infections in adult women.
GNH India supplies Miclodin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Miclodin (clotrimazole) belongs to the imidazole antifungal class and is used to treat fungal infections of the vagina.

  • Vaginal candidiasis: eradicates Candida species and relieves itching, burning and discharge.
  • Other vaginal fungal infections: treats non‑candidal yeast infections causing irritation.
  • Recurrent vaginal yeast infection: helps prevent recurrence when used as directed.

How It Works

  • Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. This disruption compromises the integrity of the fungal cell membrane, leading to increased permeability and cell death, thereby eliminating the infection at the site of application.

Side Effects

Miclodin may cause local adverse reactions, most of which are mild and self‑limiting.

Common Side Effects

  • Vaginal irritation or burning
  • Itching or mild rash at the application site
  • Unpleasant vaginal discharge
  • Local allergic reaction (redness, swelling)
  • Unpleasant odor
  • Mild discomfort during intercourse

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Persistent or worsening vaginal ulceration
  • Systemic absorption leading to liver enzyme abnormalities
  • Severe swelling of the vulva or labia
  • Unexplained fever or chills

Precautions & Warnings

Before using Miclodin, consider the following safety measures.

  • Pregnancy: consult a healthcare provider before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Allergy: avoid if you have known hypersensitivity to clotrimazole or other imidazoles.
  • Concurrent vaginal products: do not use other intravaginal medications at the same time.
  • Medical conditions: use with caution in patients with hepatic impairment.
  • Store at room temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Miclodin may interact with other medicines; review the following categories.

Major Interactions (Avoid)

  • Systemic azole antifungals: may increase systemic exposure and toxicity.
  • Topical corticosteroids: may reduce antifungal efficacy.

Moderate Interactions (Monitor Closely)

  • Antifungal resistance: prolonged use may select resistant strains.
  • Hormonal contraceptives: no direct interaction, but monitor efficacy.
  • Alcohol: no known pharmacokinetic interaction, but advise general caution.

Frequently Asked Questions

Miclodin is an over‑the‑counter antifungal medication containing clotrimazole, indicated for the treatment of vaginal candidiasis and other fungal infections of the vagina. It helps relieve symptoms such as itching, burning, and abnormal discharge by eliminating the causative yeast.

Clotrimazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of the fungal cell membrane. Without ergosterol, the membrane becomes defective, leading to fungal cell death and resolution of the infection.

The specific dose and duration of Miclodin therapy are determined by the prescribing healthcare professional based on the severity of the infection and patient factors. Patients should follow the prescriber’s instructions and the product label carefully.

Safety data for clotrimazole during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the potential risks and benefits with their healthcare provider before using Miclodin.

To request Miclodin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Clotrimazole, the active ingredient in Miclodin, is a broad‑spectrum imidazole antifungal that is generally well‑tolerated and effective for most vaginal yeast infections. Compared with polyene agents such as nystatin, clotrimazole often requires a shorter treatment course and has a lower incidence of systemic side effects.

Miclodin should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and excessive heat. Keep the product out of reach of children and avoid exposing it to direct sunlight.

Miclodin is applied intravaginally, typically using the supplied applicator or tablet form, as directed by the prescriber. The medication is inserted into the vagina for the prescribed duration, usually once daily, and patients should avoid sexual intercourse or tampon use during treatment unless advised otherwise.

Although rare, serious adverse reactions can include severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome, or persistent ulceration of the vaginal mucosa. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, widespread rash, or worsening pain.

Miclodin should not be used by individuals with a known hypersensitivity to clotrimazole, other imidazole antifungals, or any of the product’s excipients. It is also contraindicated in patients who are currently using other intravaginal medications that could interact, unless advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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