Product image of Micofenolato Mofetile Tillomed (Mycophenolate Mofetil) supplied by GNH India

Micofenolato Mofetile Tillomed

Active Ingredient:
Mycophenolate Mofetil
Origin:
EU

Micofenolato Mofetile Tillomed (Mycophenolate Mofetil)

Mycophenolate Mofetil, the active ingredient in Micofenolato Mofetile Tillomed, is an antimetabolite immunosuppressant presented as an oral formulation for oral use. It is employed to prevent organ transplant rejection and to treat selected autoimmune disorders such as lupus nephritis, acting by inhibiting lymphocyte proliferation.

GNH India supplies Micofenolato Mofetile Tillomed as a licensed, GDP‑compliant international pharmaceutical product, adhering to EU GMP standards and providing reliable supply to hospitals, transplant centres, and pharmacies across global markets through established distribution networks and regulatory support.

Manufacturer / TM Owner

Tillomed Italia S.R.L.

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Indications & Clinical Uses

Mycophenolate Mofetil is used in immunosuppressive regimens to prevent rejection and to manage certain autoimmune kidney diseases.

  • Renal transplant: helps prevent acute graft rejection.
  • Cardiac transplant: reduces the incidence of rejection episodes.
  • Lupus nephritis: improves renal function and slows disease progression.

How It Works

  • Mycophenolate Mofetil selectively and reversibly inhibits inosine monophosphate dehydrogenase (IMPDH), the key enzyme for de novo guanosine nucleotide synthesis in lymphocytes. By depleting guanosine pools, it suppresses proliferation of T and B cells, thereby dampening the immune response that drives transplant rejection and autoimmune inflammation.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Diarrhea: loose stools, sometimes watery.
  • Headache: intermittent mild to moderate pain.
  • Infections (upper respiratory): increased susceptibility to colds and sinusitis.

Serious or Rare Side Effects

  • Leukopenia: marked reduction in white blood cells.
  • Severe infections: opportunistic or systemic infections.
  • Hepatic toxicity: elevated liver enzymes or hepatitis.

Precautions & Warnings

Patients should be monitored closely for safety concerns.

  • Monitor blood counts: regular CBC to detect leukopenia or anemia.
  • Monitor liver function: periodic LFTs for hepatic toxicity.
  • Avoid in pregnancy: teratogenic risk; pregnancy category X.
  • Use effective contraception: both male and female patients of reproductive potential.
  • Adjust dose in renal impairment: follow prescriber guidance for reduced clearance.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mycophenolate Mofetil can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Azathioprine: additive bone‑marrow suppression.
  • Cyclosporine: increased mycophenolate exposure.
  • Rifampin: reduces mycophenolate plasma levels.
  • Live vaccines: heightened risk of infection.
  • Cholestyramine: decreases oral absorption.

Moderate Interactions (Monitor Closely):\n- ACE inhibitors: potential for hyperkalemia when combined with renal impairment.

  • NSAIDs: may worsen renal function.
  • Antacids (e.g., aluminum hydroxide): can lower mycophenolate bioavailability.

Frequently Asked Questions

Micofenolato Mofetile Tillomed contains mycophenolate mofetil, which is prescribed to prevent rejection after kidney, heart, or liver transplantation and to treat lupus nephritis, an autoimmune kidney disease. The drug works by suppressing the immune system, reducing the likelihood of the body attacking the transplanted organ or the kidneys affected by lupus.

Mycophenolate mofetil inhibits the enzyme inosine monophosphate dehydrogenase (IMPDH), a critical step in the synthesis of guanosine nucleotides. Lymphocytes rely on this pathway for proliferation, so the inhibition limits T‑ and B‑cell expansion, thereby dampening immune responses that cause transplant rejection or autoimmune inflammation.

The dose of Micofenolato Mofetile Tillomed is individualized by the prescribing physician based on the specific transplant protocol, renal function, and patient tolerance. Only a qualified healthcare professional should determine the appropriate dosing regimen.

Mycophenolate mofetil is classified as pregnancy category X because it can cause fetal malformations and embryotoxicity. It is contraindicated in pregnancy, and effective contraception is required for both men and women of reproductive potential. Breastfeeding is not recommended while using this medication.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Compared with calcineurin inhibitors such as cyclosporine or tacrolimus, mycophenolate mofetil offers a different mechanism—targeting lymphocyte proliferation rather than cytokine production. It is often used in combination with calcineurin inhibitors to achieve synergistic immunosuppression while allowing lower doses of each agent, potentially reducing toxicity.

The product should be stored at room temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight, and excessive heat to maintain stability and potency throughout its shelf life.

Micofenolato Mofetile Tillomed is taken orally, usually with food or a glass of water to lessen gastrointestinal irritation. The exact timing and frequency are determined by the prescribing clinician and may be adjusted based on therapeutic monitoring.

The most serious adverse events include severe bone‑marrow suppression (leukopenia, anemia), life‑threatening infections, and hepatic toxicity. Patients should be monitored regularly for blood count abnormalities and liver function changes, and any signs of infection should be reported promptly.

Patients with known hypersensitivity to mycophenolate mofetil or any component of the formulation should avoid the drug. It is also contraindicated in pregnant women, those planning pregnancy without reliable contraception, and individuals with severe uncontrolled infections or significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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