Product image of Miconal (Miconazole Nitrate) supplied by GNH India

Miconal

Active Ingredient:
Miconazole Nitrate
Origin:
EU

Miconal (Miconazole Nitrate)

Miconazole nitrate, the active ingredient in Miconal, is an imidazole antifungal presented as a vaginal formulation for local use. It is indicated for the treatment of vulvovaginal candidiasis, a common yeast infection affecting women of reproductive age. By inhibiting fungal ergosterol synthesis, the product helps to eradicate Candida species and relieve associated symptoms such as itching, burning, and abnormal discharge.

GNH India supplies Miconal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide with reliable quality assurance and regulatory compliance.

Manufacturer / TM Owner

Morgan Srl

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Indications & Clinical Uses

  • Miconal is used to treat fungal infections of the vaginal tract, specifically candidal overgrowth.
  • Vulvovaginal candidiasis: eliminates Candida species, reduces itching, burning and discharge, and helps restore normal vaginal flora.

How It Works

  • Miconazole nitrate exerts its antifungal activity by binding to the fungal enzyme lanosterol 14α‑demethylase, a cytochrome P450 isoform essential for converting lanosterol to ergosterol. Inhibition of this enzyme disrupts ergosterol synthesis, compromising the integrity of the fungal cell membrane and leading to cell death. The localized vaginal application results in high drug concentrations at the site of infection while systemic exposure remains minimal, further reducing the risk of systemic side effects.

Side Effects

Miconal may cause local adverse reactions in the vaginal area, ranging from mild irritation to rare severe events.

Common Side Effects

  • Vaginal itching or pruritus
  • Burning sensation during or after application
  • Local irritation or redness
  • Increased vaginal discharge or spotting

Serious or Rare Side Effects

  • Allergic reaction such as rash, hives, or swelling
  • Severe skin reactions including Stevens‑Johnson syndrome
  • Angioedema affecting face, lips, or throat
  • Systemic hypersensitivity with fever or malaise

Precautions & Warnings

  • Before using Miconal, consider the following precautions to ensure safe and effective treatment.
  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Allergy: avoid if known hypersensitivity to miconazole or other imidazoles.
  • Concomitant vaginal products: do not use other intravaginal medications simultaneously.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Miconal can interact with other medicines; awareness of major and moderate interactions helps avoid adverse outcomes.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic absorption of miconazole.
  • Warfarin: may enhance anticoagulant effect, requiring closer monitoring.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may have reduced efficacy; advise backup contraception.
  • Systemic azoles (e.g., fluconazole): may increase cumulative antifungal exposure.
  • Antacids containing aluminum or magnesium: may alter local pH and affect drug release.

Frequently Asked Questions

Miconal is a vaginal antifungal medication indicated for the treatment of vulvovaginal candidiasis, a common yeast infection that causes itching, burning, and abnormal discharge in women.

Miconazole nitrate inhibits the fungal enzyme lanosterol 14α‑demethylase, blocking ergosterol synthesis. This disrupts the fungal cell membrane, leading to cell death and clearance of the infection.

The prescribed dose of Miconal is determined by the treating clinician. Typically, a single vaginal dose is administered once daily for a period defined by the healthcare professional, often ranging from three to seven days.

Safety data for Miconal in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To order Miconal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Miconal delivers a high local concentration of miconazole nitrate directly to the site of infection, often resulting in faster symptom relief compared with oral azoles that rely on systemic absorption. It is also generally well tolerated and avoids many systemic drug‑drug interactions associated with oral therapy.

Store Miconal at room temperature, below 25 °C, in the original packaging. Keep it away from moisture and direct sunlight. Do not use the product after the expiry date printed on the label.

Miconal is applied intravaginally. The patient inserts the supplied tablet, cream or suppository into the vagina as directed by the prescriber, usually before bedtime to maximize contact time with the mucosa.

Serious risks include allergic reactions such as rash, hives, swelling of the face or throat, and rare severe skin conditions like Stevens‑Johnson syndrome. If any of these occur, the medication should be discontinued and medical attention sought immediately.

Miconal should not be used by individuals with a known hypersensitivity to miconazole, other imidazole antifungals, or any of the product’s excipients. Women with severe hepatic impairment should also avoid use unless specifically advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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