Miconazol Acis (Miconazole Nitrate)

Miconazol Acis is an imidazole antifungal that acts on dermatophyte and yeast infections of the skin.

• Tinea corporis: reduces redness, scaling and itching caused by ringworm on the body.
• Tinea cruris: alleviates inflammation and itching in the groin area caused by fungal infection.
• Tinea pedis: clears foot fungal infection, relieving cracking, burning and odor.
• Candidiasis: treats cutaneous yeast infections, diminishing erythema and discharge.
• Seborrheic dermatitis: improves flaky, oily scalp lesions associated with Malassezia overgrowth.

• Miconazole nitrate inhibits ergosterol synthesis by blocking the fungal enzyme lanosterol 14α‑demethylase. This disruption of the cell membrane sterol composition leads to increased membrane permeability and ultimately fungal cell death, providing a broad spectrum antifungal effect against dermatophytes and yeasts.

Miconazol Acis may cause local skin reactions, ranging from mild irritation to rare severe hypersensitivity.

Common Side Effects

• Burning sensation at the application site.
• Itching or mild pruritus.
• Redness or erythema.
• Local irritation or stinging.
• Dryness of the treated skin.
• Mild rash or papular eruption.

Serious or Rare Side Effects

• Allergic contact dermatitis.
• Angioedema or swelling of the face, lips or tongue.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Severe skin blistering or ulceration.
• Difficulty breathing or wheezing.
• Systemic hypersensitivity reactions.

Before using Miconazol Acis, consider the following safety measures.

• Apply only to intact skin: avoid broken or severely inflamed areas.
• Keep away from eyes, mouth and mucous membranes.
• Do not use on large surface areas for prolonged periods without medical advice.
• Keep out of reach of children; supervise pediatric use.
• Discontinue use and seek medical attention if severe irritation or allergic reaction occurs.
• Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Miconazol Acis may interact with other medications or topical agents.

Major Interactions (Avoid)

• Oral azole antifungals (e.g., fluconazole, itraconazole): may increase systemic exposure and toxicity.
• Systemic CYP450 inhibitors: could raise plasma levels if significant absorption occurs.

Moderate Interactions (Monitor Closely)

• Concurrent topical antifungals: may increase local irritation.
• Topical corticosteroids: can mask signs of irritation or infection.
• Skin irritants or harsh cleansers: may exacerbate local adverse reactions.
• Alcohol‑based skin preparations: could affect drug absorption.