Product image of Miconozolnitraat Sam (Miconazole Nitrate) supplied by GNH India

Miconozolnitraat Sam

Active Ingredient:
Miconazole Nitrate
Origin:
EU

Miconozolnitraat Sam (Miconazole Nitrate)

Miconazole nitrate, the active ingredient in Miconozolnitraat Sam, is a imidazole antifungal presented as a topical formulation for topical use. It treats superficial fungal skin infections such as athlete's foot, jock itch and ringworm in adults and children.
GNH India supplies Miconozolnitraat Sam as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Nederlandse Service Apotheek Beheer B.V.

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Indications & Clinical Uses

Miconozolnitraat Sam acts on dermatophyte and Candida infections of the skin.

  • Athlete's foot: reduces fungal growth and relieves itching and scaling.
  • Jock itch: treats the infection and alleviates discomfort in the groin area.
  • Ringworm: clears the skin infection and prevents spread to other body sites.

How It Works

  • Miconazole nitrate inhibits ergosterol synthesis by blocking the fungal cytochrome P450 enzyme lanosterol 14α-demethylase. This disruption impairs fungal cell membrane formation, leading to increased membrane permeability and ultimately fungal cell death.

Side Effects

Miconozolnitraat Sam may cause local skin reactions.

Common Side Effects

  • Burning sensation at the application site
  • Itching or mild irritation
  • Redness or erythema
  • Dryness or peeling of the skin
  • Local rash
  • Mild stinging

Serious or Rare Side Effects

  • Allergic contact dermatitis
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Systemic toxicity with hepatic involvement (rare)
  • Swelling of the face, lips or tongue indicating anaphylaxis
  • Blistering or ulceration of the skin
  • Persistent or worsening infection despite treatment

Precautions & Warnings

Before using Miconozolnitraat Sam, consider the following precautions.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a doctor.
  • Skin integrity: avoid applying to broken or severely inflamed skin.
  • Known allergy: discontinue if signs of hypersensitivity appear.
  • Concomitant antifungal therapy: avoid overlapping topical agents unless directed.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Miconozolnitraat Sam can interact with other medicines.

Major Interactions (Avoid)

  • Systemic azole antifungals (e.g., ketoconazole): may increase systemic exposure.
  • CYP450 substrate drugs (e.g., warfarin): potential for altered anticoagulant effect.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may reduce antifungal efficacy.
  • Antifungal shampoos or soaps: may increase skin irritation.
  • Alcohol‑based skin products: may enhance local irritation.

Frequently Asked Questions

Miconozolnitraat Sam is a topical antifungal product containing miconazole nitrate. It is used to treat superficial fungal skin infections such as athlete's foot, jock itch and ringworm by eliminating the causative fungi.

Miconazole nitrate works by inhibiting the fungal enzyme lanosterol 14α‑demethylase, which blocks ergosterol synthesis. This disruption compromises the fungal cell membrane, leading to increased permeability and cell death.

The prescribed amount and frequency are determined by the healthcare professional based on the type and severity of the infection, as well as patient‑specific factors. Patients should follow the instructions provided on the product label or by their prescriber.

Safety in pregnancy and lactation has not been fully established. It should be used only if the prescriber judges that the potential benefit outweighs any possible risk, and breastfeeding mothers should seek medical advice before use.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with allylamine agents such as terbinafine, miconazole nitrate offers a broad spectrum against dermatophytes and Candida, is available as a topical formulation, and is generally well tolerated. Efficacy may vary depending on the specific organism and infection site.

Store the product at ambient temperature below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and store out of reach of children.

Apply a thin layer of the cream or gel to the affected skin area, usually twice daily, after washing and thoroughly drying the area. Do not cover with occlusive dressings unless directed by a healthcare professional.

Rare but serious reactions include severe allergic dermatitis, Stevens‑Johnson syndrome, and systemic toxicity such as hepatic dysfunction. If signs of a serious reaction appear—such as extensive rash, swelling, or fever—discontinue use and seek immediate medical attention.

Individuals with known hypersensitivity to miconazole or other imidazole antifungals, patients with extensive broken skin in the intended application area, or those advised against topical antifungals by their physician should avoid using this product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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