Product image of Micotef (Miconazole) supplied by GNH India

Micotef

Active Ingredient:
Miconazole
Origin:
EU

Micotef (Miconazole)

Miconazole, the active ingredient in Micotef, is an imidazole antifungal presented as a vaginal formulation for local use. It treats vaginal candidiasis by targeting fungal cells and is intended for adult women experiencing yeast infections.
GNH India supplies Micotef as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teofarma S.R.L.

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Indications & Clinical Uses

Micotef belongs to the imidazole antifungal class and is used to treat fungal infections of the female genital tract.

  • Vaginal candidiasis: eliminates Candida overgrowth and relieves itching, burning and discharge.
  • Recurrent vulvovaginal candidiasis: reduces the frequency of recurring yeast infection episodes.
  • Vulvar candidiasis: provides symptomatic relief and eradicates fungal infection of the vulva.

How It Works

  • Miconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking this pathway, the drug disrupts cell membrane formation, leading to increased membrane permeability and ultimately fungal cell death. The action is localized to the site of application, minimizing systemic exposure.

Side Effects

Miconazole may cause local and systemic adverse reactions.

Common Side Effects

  • Vaginal irritation or burning sensation.
  • Itching or mild rash at the application site.
  • Unpleasant vaginal discharge or odor.
  • Mild abdominal discomfort.

Serious or Rare Side Effects

  • Allergic reaction with swelling, hives or difficulty breathing.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Liver toxicity presenting as jaundice or abnormal liver tests.

Precautions & Warnings

Use Micotef only after confirming a fungal cause of symptoms and follow prescriber instructions.

  • Confirm diagnosis: ensure infection is due to Candida before initiating therapy.
  • Avoid latex condoms: the product may degrade latex and cause irritation.
  • Allergy check: do not use if known hypersensitivity to imidazoles.
  • Limit duration: adhere to prescribed treatment length to reduce resistance risk.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Miconazole can interact with other medications, requiring attention to potential effects.

Major Interactions (Avoid)

  • Systemic azoles (e.g., ketoconazole): may increase systemic absorption of miconazole.
  • Warfarin: potential enhancement of anticoagulant effect.
  • Rifampin: may reduce antifungal efficacy.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: possible reduction in effectiveness.
  • Antacids containing aluminum or magnesium: may affect local absorption.
  • Topical steroids: may mask local irritation or infection signs.

Frequently Asked Questions

Micotef contains the antifungal agent miconazole and is used to treat vaginal candidiasis, a common yeast infection in women. It works by eliminating the Candida species that cause symptoms such as itching, burning, and abnormal discharge.

Miconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, which is essential for ergosterol synthesis. This disruption weakens the fungal cell membrane, leading to increased permeability and cell death, thereby clearing the infection.

The appropriate dose of Micotef is determined by the prescribing healthcare professional based on the severity of infection and patient factors. Patients should follow the exact instructions provided by their prescriber and not alter the regimen on their own.

Safety of Micotef in pregnancy or while breastfeeding has not been definitively established. Women who are pregnant, planning to become pregnant, or nursing should discuss potential risks and benefits with their healthcare provider before using the product.

To order Micotef, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Micotef’s active ingredient, miconazole, belongs to the imidazole class and offers a broad spectrum against Candida species. Compared with azole alternatives such as clotrimazole, miconazole provides similar efficacy with a favorable local tolerability profile, making it a common choice for vaginal applications.

Micotef should be stored at room temperature, below 25 °C, in its original packaging. Keep it away from moisture and direct sunlight to maintain product stability and effectiveness.

Micotef is applied intravaginally as directed by a healthcare professional. The product is inserted into the vagina using the supplied applicator or as instructed, ensuring proper placement for optimal local absorption.

Serious risks, though rare, include severe allergic reactions such as swelling, hives, or difficulty breathing, and rare skin conditions like Stevens‑Johnson syndrome. Any signs of a serious reaction require immediate medical attention.

Individuals with a known hypersensitivity to miconazole, other imidazoles, or any component of the formulation should avoid using Micotef. Additionally, patients with severe liver disease or those taking interacting medications should consult a healthcare provider before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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