Product image of Micrazym (Amylase, Lipase, Protease) supplied by GNH India

Micrazym

Active Ingredient:
Amylase, Lipase, Protease
Origin:
EU

Micrazym (Amylase, Lipase, Protease)

Amylase, Lipase, Protease, the active ingredients in Micrazym, are an enzyme replacement therapy presented as an oral formulation for oral use. They aid patients with exocrine pancreatic insufficiency and related malabsorption disorders by supplying the digestive enzymes that the pancreas fails to produce sufficiently, catalyzing the breakdown of carbohydrates, fats and proteins to support nutrient absorption.

GNH India supplies Micrazym as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Avva Pharmaceuticals Limited

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Indications & Clinical Uses

  • Micrazym is used to support digestive function in conditions characterized by exocrine pancreatic insufficiency.
  • Exocrine pancreatic insufficiency: improves digestion of fats, proteins and carbohydrates by providing missing enzymes.
  • Cystic fibrosis–related pancreatic insufficiency: enhances nutrient absorption in patients with cystic fibrosis.
  • Chronic pancreatitis: reduces steatorrhea and malnutrition by supplementing pancreatic enzymes.
  • Post‑pancreatic resection (e.g., after pancreatic cancer surgery): assists in maintaining adequate digestion after loss of pancreatic tissue.

How It Works

  • Micrazym delivers exogenous amylase, lipase, and protease to the gastrointestinal tract, where these enzymes catalyze the hydrolysis of dietary carbohydrates, triglycerides, and proteins respectively. By supplementing the deficient endogenous pancreatic enzymes, the preparation restores normal digestive processes, facilitating the breakdown of macronutrients into absorbable units and improving overall nutrient uptake.

Side Effects

Common Side Effects

  • Abdominal discomfort or cramping.
  • Flatulence or gas.
  • Diarrhea or loose stools.
  • Nausea or mild vomiting.
  • Constipation.
  • Unpleasant taste or after‑taste.

Serious or Rare Side Effects

  • Allergic reactions including rash, itching, or anaphylaxis.
  • Severe abdominal pain or pancreatitis exacerbation.
  • Persistent vomiting or dehydration.
  • Eosinophilia or other blood dyscrasias.
  • Intestinal obstruction.
  • Unexplained weight loss despite therapy.

Precautions & Warnings

  • Precautions should be observed when initiating Micrazym therapy.
  • Assess pancreatic function: confirm exocrine insufficiency before use.
  • Monitor nutritional status: track weight, vitamin levels and stool consistency.
  • Adjust dose in renal or hepatic impairment: consider reduced dosing if organ function is compromised.
  • Avoid use in known hypersensitivity: discontinue if allergic signs appear.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Micrazym may interact with other agents that affect gastric pH or fat digestion.

Major Interactions (Avoid)

  • Antacids containing magnesium or aluminum: may reduce enzyme activity.
  • Proton pump inhibitors: altered gastric acidity can affect enzyme efficacy.
  • Broad‑spectrum antibiotics: disruption of gut flora may modify digestion.

Moderate Interactions (Monitor Closely)

  • Orlistat: concurrent use may interfere with fat digestion.
  • High‑fat meals: may require dose adjustment for optimal effect.
  • Fat‑soluble vitamin supplements: monitor levels as absorption may change.

Frequently Asked Questions

Micrazym is an oral enzyme replacement product that provides amylase, lipase and protease to patients with exocrine pancreatic insufficiency or related malabsorption disorders. It helps break down carbohydrates, fats and proteins, improving nutrient absorption and reducing symptoms such as steatorrhea, bloating and weight loss.

The three enzymes in Micrazym act in the gastrointestinal tract: amylase hydrolyzes starches into sugars, lipase splits triglycerides into fatty acids and monoglycerides, and protease cleaves proteins into peptides and amino acids. By supplying these enzymes externally, Micrazym compensates for the deficient pancreatic output in affected patients.

The appropriate dose of Micrazym is determined by the prescribing healthcare professional based on the individual’s degree of pancreatic insufficiency, dietary fat content and clinical response. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for Micrazym in pregnancy and lactation are limited. The decision to use the product should be made by a qualified healthcare provider after weighing the potential benefits for the mother against any possible risks to the fetus or infant.

To request Micrazym, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Micrazym contains a combination of amylase, lipase and protease, similar to many standard pancreatic enzyme preparations. Its distinguishing features are the specific enzyme ratios and the EU‑origin manufacturing standards. Clinical effectiveness depends on appropriate dosing and patient adherence, which are comparable across reputable enzyme products.

Micrazym should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, excessive heat and direct sunlight to maintain enzyme stability. Do not refrigerate or freeze unless the label specifically advises otherwise.

Micrazym is taken orally, usually with meals or snacks that contain fat, protein and carbohydrate. The tablets or capsules should be swallowed whole with water unless the prescribing information indicates a different method, such as sprinkling on soft food for patients with swallowing difficulties.

Serious risks, although rare, include allergic reactions that may progress to anaphylaxis, severe abdominal pain indicating possible pancreatitis exacerbation, and persistent vomiting leading to dehydration. Patients should seek immediate medical attention if they experience any of these symptoms.

Micrazym should not be used by individuals with a known hypersensitivity to any of its enzyme components or excipients. It is also contraindicated in patients with active gastrointestinal obstruction or severe acute pancreatitis until the underlying condition is resolved.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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