Product image of Micrazym (Pancreatin) supplied by GNH India

Micrazym

Active Ingredient:
Pancreatin
Origin:
EU

Micrazym (Pancreatin)

Pancreatin, the active ingredient in Micrazym, is a digestive enzyme presented as an oral formulation for oral use. It supplies the pancreatic enzymes that are deficient in conditions such as exocrine pancreatic insufficiency, helping to hydrolyze proteins, fats, and carbohydrates for improved nutrient absorption.

GNH India supplies Micrazym as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution, ensuring product integrity across markets.

Manufacturer / TM Owner

Allgen Pharmaceuticals & Generics Bv

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Indications & Clinical Uses

Micrazym, containing pancreatin, is used in the management of disorders characterized by pancreatic enzyme deficiency.

  • Exocrine pancreatic insufficiency: Improves digestion and nutrient absorption by supplying missing enzymes.
  • Cystic fibrosis‑related pancreatic insufficiency: Reduces gastrointestinal symptoms and supports growth.
  • Chronic pancreatitis: Alleviates malabsorption and steatorrhea associated with reduced pancreatic output.
  • Post‑pancreatectomy patients: Assists in digestion after surgical removal of pancreatic tissue.

How It Works

  • Pancreatin provides a mixture of lipase, amylase, and protease enzymes that mimic the activity of the pancreas. When taken orally, the enzymes are released in the duodenum where they hydrolyze dietary fats, carbohydrates, and proteins into absorbable molecules, compensating for the deficient endogenous pancreatic secretion and facilitating normal digestive processes. The formulation is designed to resist gastric acidity and become active in the intestinal lumen, ensuring optimal enzymatic activity.

Side Effects

Pancreatin may cause a range of adverse reactions, most of which are mild and related to gastrointestinal tolerance.

Common Side Effects

  • Abdominal discomfort: mild pain or cramping in the stomach area.
  • Flatulence: increased gas production leading to bloating.
  • Diarrhea: loose stools occurring after dosing.
  • Nausea: feeling of sickness or urge to vomit.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or anaphylaxis in susceptible individuals.
  • Severe abdominal pain: may indicate pancreatitis exacerbation.
  • Intestinal obstruction: blockage symptoms such as vomiting and inability to pass gas.

Precautions & Warnings

When prescribing Micrazym, clinicians should consider several precautionary measures to ensure safe and effective use.

  • Assess pancreatic function: confirm enzyme deficiency before initiating therapy.
  • Monitor for allergic reactions: discontinue if signs of hypersensitivity appear.
  • Adjust dose based on clinical response: titrate to achieve symptom control.
  • Avoid use in patients with known hypersensitivity to porcine‑derived products: pancreatin is typically derived from pig pancreas.
  • Caution in patients with ulcerative colitis or inflammatory bowel disease: may exacerbate symptoms.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture.

Avoid Interactions

Pancreatin can interact with certain medications, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: neutralize gastric acidity and reduce enzyme activity.
  • Cholestyramine or other bile acid sequestrants: bind pancreatic enzymes and diminish absorption.

Moderate Interactions (Monitor Closely)

  • Proton pump inhibitors: may alter gastric pH, potentially affecting enzyme activation; monitor therapeutic response.
  • Oral contraceptives: rare reports of altered hormone levels; observe for any changes.
  • Antibiotics such as tetracycline: may cause gastrointestinal upset when combined; assess tolerability.

Frequently Asked Questions

Micrazym is an oral pancreatic enzyme preparation used to replace deficient digestive enzymes in patients with exocrine pancreatic insufficiency. It helps improve the breakdown and absorption of proteins, fats, and carbohydrates, thereby reducing symptoms such as steatorrhea, abdominal discomfort, and malnutrition associated with conditions like cystic fibrosis, chronic pancreatitis, or after pancreatic surgery.

Pancreatin contains a blend of lipase, amylase, and protease enzymes that replicate the natural activity of the pancreas. After oral ingestion, the enzymes are protected from stomach acid and released in the small intestine where they catalyze the hydrolysis of dietary fats, carbohydrates, and proteins into smaller molecules that can be readily absorbed, compensating for the body's own enzyme shortfall.

The appropriate dose of Micrazym is individualized and determined by the prescribing healthcare professional based on the patient’s age, weight, severity of enzyme deficiency, and dietary fat intake. Dosage adjustments are made according to clinical response and tolerance, and patients should follow the specific instructions provided by their prescriber.

Safety data for Micrazym in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should evaluate each case carefully and discuss any concerns with the patient before initiating therapy.

To request Micrazym, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After receiving the enquiry, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements if applicable), and assist with import documentation.

Micrazym contains pancreatin derived from porcine pancreas, similar to many other pancreatic enzyme preparations. Differences among products generally relate to enzyme activity units, formulation (enteric‑coated tablets, capsules, or powders), and excipients. Clinicians may choose Micrazym based on its specific activity profile, patient tolerance, and availability through GNH India’s global supply network.

Micrazym should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains tightly closed. Do not store in a refrigerator or freezer unless the manufacturer’s label explicitly states otherwise.

Micrazym is taken orally, usually with each main meal and snack that contains fat. The tablets or capsules should be swallowed whole with a sufficient amount of water. Dosing may be adjusted based on the size of the meal and the patient’s clinical response, following the prescriber’s guidance.

The most serious adverse events associated with Micrazym include allergic reactions such as rash, itching, swelling, or anaphylaxis, severe abdominal pain that could signal pancreatitis exacerbation, and rare cases of intestinal obstruction. Patients should seek immediate medical attention if they experience any of these symptoms.

Micrazym should be avoided in individuals with a known hypersensitivity to pancreatin or any porcine‑derived products. Patients with severe active gastrointestinal disease where enzyme therapy is contraindicated should also refrain from use. As always, a healthcare professional should assess suitability before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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