Product image of Microginon (Ethinylestradiol, Levonorgestrel) supplied by GNH India

Microginon

Active Ingredient:
Ethinylestradiol, Levonorgestrel
Origin:
EU

Microginon (Ethinylestradiol, Levonorgestrel)

Ethinylestradiol and Levonorgestrel, the active ingredients in Microginon, are a combined oral contraceptive presented as a tablet for oral use. They prevent pregnancy in women of reproductive age by suppressing ovulation and altering cervical mucus.

GNH India supplies Microginon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Portugal Lda

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Indications & Clinical Uses

Microginon, a combined oral contraceptive, is used to prevent pregnancy by modulating the hormonal axis.

  • Prevention of pregnancy: provides reliable contraceptive protection for women of childbearing age.
  • Menstrual cycle regulation: helps achieve more predictable menstrual bleeding patterns.
  • Acne improvement: can reduce acne associated with androgen excess.

How It Works

  • Ethinylestradiol and levonorgestrel act by suppressing the hypothalamic‑pituitary‑gonadal axis, inhibiting the release of luteinising hormone (LH) and follicle‑stimulating hormone (FSH). This prevents ovulation, while the progestin component induces cervical‑mucus changes that impede sperm penetration and alters the endometrial lining to reduce the likelihood of implantation.

Side Effects

Microginon may cause a range of adverse reactions. Most are mild and transient, but serious events can occur.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or migraine‑like.
  • Breast tenderness: discomfort or swelling.
  • Spotting or irregular bleeding: especially during the first months.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or mood swings.

Serious or Rare Side Effects

  • Deep vein thrombosis: blood clot formation in deep veins.
  • Pulmonary embolism: clot migration to the lungs.
  • Stroke: cerebrovascular accident due to clot or hemorrhage.
  • Myocardial infarction: heart attack risk in susceptible individuals.
  • Severe allergic reaction (anaphylaxis): rapid onset of hives, swelling, breathing difficulty.
  • Liver tumor: rare benign hepatic adenoma.

Precautions & Warnings

Before prescribing Microginon, clinicians should evaluate several safety aspects.

  • Thromboembolic risk assessment: avoid in women with history of clotting disorders.
  • Blood pressure monitoring: contraindicated in uncontrolled hypertension.
  • Smoking status: caution in smokers over 35 years of age.
  • Cancer history review: avoid in estrogen‑dependent tumor history.
  • Breastfeeding counseling: discuss benefits and risks if used during lactation.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Microginon can interact with other medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Antiepileptic enzyme inducers (e.g., carbamazepine, phenytoin): reduce contraceptive efficacy.
  • Rifampin: markedly decreases hormone levels.
  • Griseofulvin: may lower effectiveness of the pill.
  • Certain antiretroviral protease inhibitors (e.g., ritonavir): can increase hormone concentrations.
  • St. John’s wort: herbal inducer that diminishes contraceptive protection.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (e.g., ketoconazole): may raise estrogen levels.
  • SSRIs (e.g., fluoxetine): can increase bleeding tendency.
  • Thiazide diuretics: may exacerbate hypertension.
  • Herbal supplements (e.g., ginseng): potential metabolic interaction.
  • High‑dose vitamin C: may elevate estrogen exposure.

Frequently Asked Questions

Microginon is a combined oral contraceptive containing ethinylestradiol and levonorgestrel. It is prescribed to prevent pregnancy in women of reproductive age by inhibiting ovulation and altering cervical mucus and endometrial conditions to reduce the chance of fertilisation and implantation.

Ethinylestradiol provides estrogenic activity while levonorgestrel supplies progestogenic effects. Together they suppress the hypothalamic‑pituitary‑gonadal axis, preventing the surge of luteinising hormone and follicle‑stimulating hormone needed for ovulation. The progestin also thickens cervical mucus and makes the uterine lining less suitable for implantation.

The specific dosing regimen for Microginon is determined by the prescribing healthcare professional. Typically, a combined oral contraceptive is taken as one tablet daily at the same time each day, but the exact schedule and any missed‑dose instructions are provided by the prescriber.

Microginon is not intended for use during pregnancy and should be discontinued if pregnancy occurs. While some combined oral contraceptives are considered compatible with breastfeeding after the first six weeks postpartum, the prescriber will evaluate individual risk‑benefit factors before recommending use during lactation.

To order Microginon, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any required temperature control) and assist with import documentation.

Microginon contains the widely used dose combination of ethinylestradiol and levonorgestrel, offering a balance of efficacy and tolerability comparable to other second‑generation combined pills. Compared with newer formulations that may use different progestins, Microginon’s profile is well‑characterised, making it a reliable option for most women when contraindications are absent.

Microginon tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect from moisture, heat and direct sunlight, and keep out of reach of children.

Microginon is taken orally with a glass of water, usually once daily at the same time each day. It is important to follow the prescriber’s instructions regarding the start of a new pack and actions to take if a dose is missed.

The most serious risks include venous thromboembolism (deep‑vein thrombosis, pulmonary embolism), arterial events such as stroke or myocardial infarction, and rare severe allergic reactions. Women with a history of clotting disorders, uncontrolled hypertension, smoking over age 35, or estrogen‑dependent tumors should be evaluated carefully before use.

Microginon is contraindicated in women with known or suspected pregnancy, active or history of thromboembolic disease, uncontrolled hypertension, certain estrogen‑dependent cancers, severe liver disease, or those who are breastfeeding within the first six weeks postpartum. It should also be avoided in smokers over 35 years of age unless an alternative method is chosen.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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