Product image of Microgynon (Ethinylestradiol, Levonorgestrel) supplied by GNH India

Microgynon

Active Ingredient:
Ethinylestradiol, Levonorgestrel
Origin:
EU

Microgynon (Ethinylestradiol, Levonorgestrel)

Ethinylestradiol, the active ingredient in Microgynon, is a combined estrogen‑progestogen oral contraceptive presented as a 30 µg ethinylestradiol / 150 µg levonorgestrel oral tablet for oral use. It prevents pregnancy and provides hormonal contraception for women of reproductive age.

GNH India supplies Microgynon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bayer Sa Nv

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Indications & Clinical Uses

  • Microgynon, a combined estrogen‑progestogen oral contraceptive, is used within the hormonal contraception pathway to prevent pregnancy.
  • Prevention of pregnancy: provides reliable contraception by suppressing ovulation and altering cervical mucus.
  • Regulation of menstrual cycles: helps achieve more predictable bleeding patterns and reduces menstrual flow.
  • Management of dysmenorrhea: can lessen menstrual pain through hormonal stabilization.

How It Works

  • Ethinylestradiol and levonorgestrel bind to estrogen and progesterone receptors, respectively, suppressing the hypothalamic‑pituitary‑ovarian axis. This inhibition prevents the mid‑cycle luteinizing hormone surge, thereby blocking ovulation. In addition, the progestogen component thickens cervical mucus and the estrogen component modifies the endometrial lining, creating an environment unfavorable for implantation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset, often transient.
  • Breast tenderness: swelling or discomfort of the breasts.
  • Headache: occasional tension‑type headache.
  • Spotting between periods: light vaginal bleeding.

Serious or Rare Side Effects

  • Deep vein thrombosis: blood clot formation in deep veins, requiring immediate medical attention.
  • Pulmonary embolism: clot migration to the lungs, a life‑threatening emergency.
  • Severe allergic reaction: hives, swelling, or anaphylaxis requiring urgent care.

Precautions & Warnings

Before prescribing Microgynon, clinicians should consider the following precautions:

  • Assess cardiovascular risk: avoid in women with a history of thromboembolic disorders.
  • Screen for smoking status: contraindicated in smokers over 35 years of age.
  • Evaluate liver function: use with caution in hepatic impairment.
  • Consider drug interactions: avoid concomitant use with enzyme‑inducing medicines that may reduce efficacy.
  • Store at ambient temperature: keep below 25 °C, retain original packaging, and protect from moisture.

Avoid Interactions

Microgynon may interact with several medicines that affect hormone metabolism.

Major Interactions (Avoid)

  • Enzyme‑inducing anticonvulsants (e.g., carbamazepine, phenytoin): markedly reduce contraceptive effectiveness.
  • Rifampicin: significantly lowers hormone levels, increasing risk of unintended pregnancy.
  • Protease inhibitors (e.g., ritonavir): can alter hormone metabolism and compromise efficacy.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., ampicillin, tetracycline): may slightly reduce efficacy; monitor menstrual cycle.
  • St. John’s wort: may decrease hormone concentrations; advise caution.
  • Diuretics (e.g., spironolactone): may increase risk of hypertension; monitor blood pressure.

Frequently Asked Questions

Microgynon is a combined estrogen‑progestogen oral contraceptive used to prevent pregnancy. It provides reliable hormonal birth control for women of reproductive age by inhibiting ovulation and creating cervical and endometrial conditions that are unfavorable for fertilisation and implantation.

Ethinylestradiol and levonorgestrel act on estrogen and progesterone receptors to suppress the hypothalamic‑pituitary‑ovarian axis, preventing the luteinising hormone surge that triggers ovulation. The progestogen also thickens cervical mucus, while the estrogen modifies the endometrial lining, together reducing the chance of fertilisation and implantation.

The prescribed dose of Microgynon is determined by the treating healthcare professional. The product is supplied as a tablet containing 30 µg ethinylestradiol and 150 µg levonorgestrel, and the prescriber will advise the appropriate daily regimen based on individual clinical assessment.

Microgynon is classified as pregnancy category X, meaning it must not be used during pregnancy because it can cause harm to the fetus. It is also not recommended while breastfeeding, as hormonal components may pass into breast milk and affect the infant. Women should discontinue use if pregnancy is confirmed.

To order Microgynon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any required import documentation.

Microgynon contains a low‑dose estrogen (30 µg ethinylestradiol) combined with levonorgestrel, a second‑generation progestogen. Compared with higher‑dose formulations, it may have a slightly lower risk of estrogen‑related side effects while maintaining contraceptive efficacy. Its safety profile and dosing schedule are similar to other low‑dose combined pills, but individual tolerability can vary.

Microgynon tablets should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Microgynon is taken orally, usually once daily at the same time each day. The tablet is swallowed with water and should be started according to the prescribing clinician’s instructions, typically on the first day of the menstrual period or after a hormone‑free interval.

The most serious risks include thromboembolic events such as deep vein thrombosis and pulmonary embolism, as well as rare but severe allergic reactions. Women with a history of clotting disorders, smoking over age 35, or certain cardiovascular conditions should avoid use and discuss alternatives with their healthcare provider.

Microgynon is contraindicated in women who are pregnant, have known or suspected breast cancer, have a history of thromboembolic disease, uncontrolled hypertension, severe liver disease, or are smokers over 35 years of age. It should also be avoided in individuals with known hypersensitivity to any component of the tablet.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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