Mikronizované Flavonoidy Agmed (Micronised Purified Flavonoic Fraction)

Mikronizované Flavonoidy Agmed, a flavonoid preparation, is used to address conditions linked to oxidative stress and micro‑vascular function.

• Vascular health support: helps maintain normal blood vessel elasticity and endothelial function.
• Antioxidant support: contributes to neutralising free radicals and reducing oxidative damage.
• Capillary fragility reduction: may assist in decreasing capillary permeability in mild circulatory disturbances.

• Micronised Purified Flavonoic Fraction consists of a mixture of flavonoid aglycones and glycosides that, after oral absorption, exert antioxidant activity by scavenging reactive oxygen species, modulating endothelial nitric oxide synthase, and inhibiting platelet aggregation. The micronisation enhances dissolution and bioavailability, allowing the compounds to interact with vascular endothelial cells and inflammatory pathways.

Mikronizované Flavonoidy Agmed is generally well tolerated, but some adverse reactions have been reported.

Common Side Effects

• Mild gastrointestinal discomfort: occasional stomach upset or dyspepsia.
• Transient headache: short‑lasting headache without neurological signs.
• Nausea: occasional feeling of queasiness, usually mild.

Serious or Rare Side Effects

• Allergic reactions: rash, pruritus, or angioedema requiring medical attention.
• Hepatic enzyme elevation: rare increase in liver function tests.
• Bleeding tendency: heightened risk of bleeding, especially in patients on anticoagulant therapy.

Before initiating therapy with Mikronizované Flavonoidy Agmed, consider the following precautions.

• Assess renal function: use with caution in severe renal impairment.
• Monitor for hypersensitivity: discontinue if rash or other allergic signs appear.
• Avoid concurrent high‑dose anticoagulants: increased bleeding risk.
• Pregnancy and lactation: use only if clearly needed after risk assessment.
• Review concomitant supplements: potential additive effects with other flavonoid‑rich products.
• Store at ambient temperature: keep in the original pack, protect from moisture.

Mikronizované Flavonoidy Agmed may interact with several medicines; categorize the interactions by clinical significance.

Major Interactions (Avoid)

• Warfarin: may potentiate anticoagulant effect and increase bleeding risk.
• Strong CYP3A4 inhibitors: could raise plasma flavonoid concentrations.
• High‑dose vitamin K supplements: may diminish the product's vascular benefits.

Moderate Interactions (Monitor Closely)

• Aspirin: additive antiplatelet activity may increase bleeding tendency.
• NSAIDs: combined use may enhance gastrointestinal irritation.
• Statins: possible metabolic interaction requiring monitoring of lipid levels.