Product image of Micropam (Diazepam) supplied by GNH India

Micropam

Active Ingredient:
Diazepam
Origin:
EU

Micropam (Diazepam)

Diazepam, the active ingredient in Micropam, is a benzodiazepine presented as a rectal formulation for rectal use. It acts on the central nervous system to provide rapid relief of anxiety, control acute seizure activity, reduce muscle spasm, and alleviate symptoms associated with alcohol withdrawal in suitable patients.

GNH India supplies Micropam as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality compliance with EU standards and reliable global distribution, including timely logistics, regulatory support and after‑sales service.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

Diazepam, a benzodiazepine, modulates GABA‑A receptors to treat several central nervous system conditions.

  • Anxiety disorders: reduces excessive anxiety and tension.
  • Seizure disorders: controls acute seizure activity and status epilepticus.
  • Muscle spasm: relaxes skeletal muscle tone.
  • Alcohol withdrawal: mitigates tremor, agitation and risk of seizures.

How It Works

  • Diazepam binds to the benzodiazepine site on the GABA‑A receptor complex, increasing the frequency of chloride channel opening in response to GABA. This potentiates inhibitory neurotransmission, leading to hyperpolarization of neuronal membranes and decreased neuronal excitability, which underlies its anxiolytic, anticonvulsant, muscle‑relaxant and sedative effects. The modulation is dose‑dependent, reversible, and does not directly activate the receptor, allowing normal GABA activity to be enhanced without replacing the neurotransmitter.

Side Effects

Diazepam may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Drowsiness
  • Dizziness
  • Fatigue
  • Impaired coordination

Serious or Rare Side Effects

  • Respiratory depression
  • Paradoxical agitation
  • Dependence and withdrawal syndrome

Precautions & Warnings

When prescribing Micropam, clinicians should consider several safety measures.

  • Assess patient history: evaluate for respiratory depression, hepatic impairment, or glaucoma.
  • Avoid abrupt discontinuation: taper under medical supervision to prevent withdrawal.
  • Monitor sedation: caution when operating machinery or driving.
  • Use with caution in elderly: increased sensitivity to CNS effects.
  • Pregnancy and lactation: assess risk–benefit, limited data available.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Diazepam interacts with various medicines; some combinations require avoidance, others close monitoring.

Major Interactions (Avoid)

  • CNS depressants (e.g., opioids, barbiturates): additive sedation and respiratory depression.
  • Azole antifungals (e.g., ketoconazole): increase diazepam plasma levels.
  • Macrolide antibiotics (e.g., erythromycin): may raise diazepam concentrations.

Moderate Interactions (Monitor Closely)

  • Antidepressants (e.g., SSRIs): may enhance CNS effects.
  • Antihistamines: increase sedation.
  • Alcohol: potentiates sedative effects.

Frequently Asked Questions

Micropam contains diazepam and is indicated for the short‑term management of anxiety disorders, the control of acute seizure activity, relief of muscle spasm, and mitigation of symptoms during alcohol withdrawal. It is administered rectally, providing a rapid route of absorption for emergency or acute situations.

Diazepam binds to a specific site on the GABA‑A receptor complex, enhancing the effect of the inhibitory neurotransmitter GABA. This increases chloride ion influx, hyperpolarising neurons and reducing excitability, which produces anxiolytic, anticonvulsant, muscle‑relaxant and sedative actions.

The appropriate dose of Micropam is determined by the prescribing clinician based on the patient’s condition, age, weight, and response to therapy. Dosage may vary for anxiety, seizure control, muscle spasm, or alcohol‑withdrawal management, and should follow local prescribing guidelines.

Safety data for rectal diazepam in pregnancy and lactation are limited. Clinicians should weigh potential benefits against possible risks to the fetus or infant, and use the product only if clearly indicated. Consultation with a specialist is recommended before prescribing to pregnant or nursing women.

To request Micropam, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Micropam delivers diazepam via the rectal route, offering rapid absorption compared with oral tablets. Compared with alternatives such as lorazepam or clonazepam, diazepam has a longer half‑life, which may reduce dosing frequency but can prolong sedation. Choice of agent depends on clinical context, required onset, and duration of action.

Micropam should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperatures. Keep out of reach of children and ensure the rectal applicator remains sealed until use.

Micropam is supplied as a rectal preparation. The prescribed dose is placed into the rectum using the provided applicator, allowing the medication to be absorbed through the rectal mucosa. Administration should be performed according to the healthcare professional’s instructions to ensure proper dosing and efficacy.

Serious adverse events include respiratory depression, paradoxical agitation (increased anxiety or aggression), and the development of physical dependence leading to withdrawal syndrome upon abrupt discontinuation. Patients should be monitored closely for these reactions, especially when used with other central nervous system depressants.

Micropam is contraindicated in patients with known hypersensitivity to diazepam or other benzodiazepines, those with severe respiratory insufficiency, acute narrow‑angle glaucoma, and individuals with severe hepatic impairment. Caution is also advised for the elderly, pregnant women, and patients with a history of substance abuse.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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