Product image of Micutan (Terbinafine) supplied by GNH India

Micutan

Active Ingredient:
Terbinafine
Origin:
EU

Micutan (Terbinafine)

Terbinafine, the active ingredient in Micutan, is a allylamine antifungal presented as an oral tablet for oral use. It treats fungal infections of the skin and nails, including onychomycosis, tinea pedis and tinea corporis, in adult patients.
GNH India supplies Micutan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Giuliani Spa

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Indications & Clinical Uses

Micutan (terbinafine) is indicated for fungal infections affecting the skin and nails.

  • Onychomycosis: eradicates the causative dermatophytes, leading to regrowth of healthy nail tissue.
  • Tinea pedis: relieves foot fungal infection, reducing scaling and itching.
  • Tinea corporis: clears body ringworm lesions, restoring normal skin appearance.

How It Works

  • Terbinafine inhibits the fungal enzyme squalene epoxidase, disrupting the synthesis of ergosterol, an essential component of fungal cell membranes. This inhibition causes accumulation of toxic squalene within the cell and depletion of ergosterol, resulting in increased membrane permeability and fungal cell death.

Side Effects

Terbinafine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, abdominal discomfort or diarrhea.
  • Skin reactions: rash, pruritus or mild erythema.
  • Taste disturbances: dysgeusia or loss of taste.
  • Headache: mild to moderate intensity.
  • Elevated liver enzymes: transient increases in hepatic transaminases.

Serious or Rare Side Effects

  • Hepatotoxicity: hepatitis, jaundice or severe liver injury.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hematologic abnormalities: neutropenia or agranulocytosis.
  • Peripheral neuropathy: numbness or tingling in extremities.
  • Severe allergic reactions: anaphylaxis or angioedema.

Precautions & Warnings

Before prescribing Micutan, clinicians should consider several safety aspects.

  • Liver function: assess baseline hepatic enzymes and monitor periodically.
  • Drug interactions: review concomitant medications that affect CYP450 enzymes.
  • Renal impairment: adjust therapy if significant renal dysfunction is present.
  • Pregnancy and lactation: evaluate risk‑benefit ratio as safety data are limited.
  • Age considerations: use caution in elderly patients due to potential comorbidities.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Avoid Interactions

Terbinafine can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase terbinafine levels.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce efficacy.
  • Cimetidine: can raise terbinafine plasma concentration.

Moderate Interactions (Monitor Closely)

  • Warfarin: monitor INR for potential anticoagulant effect changes.
  • Antidepressants metabolized by CYP2C9/2C19: observe for altered plasma levels.
  • HIV protease inhibitors: assess for increased risk of hepatotoxicity.

Frequently Asked Questions

Micutan contains terbinafine, an oral allylamine antifungal indicated for the treatment of onychomycosis (fungal nail infection), tinea pedis (athlete's foot), and tinea corporis (ringworm of the body). It works by eliminating the dermatophyte fungi responsible for these conditions, helping restore normal skin and nail health.

Terbinafine blocks the fungal enzyme squalene epoxidase, which is essential for producing ergosterol, a key component of fungal cell membranes. The resulting buildup of squalene and loss of ergosterol disrupts membrane integrity, leading to fungal cell death and clearance of the infection.

The dosage of Micutan is determined by the prescribing clinician based on the specific infection, patient weight, renal and hepatic function, and other individual factors. Physicians set the appropriate regimen, and patients should follow the prescribed instructions without alteration.

Safety data for terbinafine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers must evaluate each case individually and discuss potential risks with the patient.

To request Micutan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

The primary alternative to terbinafine is itraconazole, a triazole antifungal. Terbinafine generally offers a shorter treatment duration for nail infections and has a different safety profile, with less hepatic enzyme induction than itraconazole. Choice of therapy depends on infection type, patient tolerance and drug‑interaction considerations.

Micutan should be stored at ambient temperature, below 25 °C. Keep the tablets in their original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Micutan is taken orally, usually with a full glass of water. It may be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and any dietary considerations.

Serious adverse events include hepatotoxicity (elevated liver enzymes, hepatitis, jaundice), severe skin reactions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis, peripheral neuropathy, and rare blood disorders like neutropenia. Patients should seek immediate medical attention if they notice signs of liver injury, rash, or neurological symptoms.

Micutan is contraindicated in patients with known hypersensitivity to terbinafine or any component of the formulation. Caution is advised for individuals with pre‑existing liver disease, severe renal impairment, or those taking medications that strongly interact with terbinafine metabolism. Pregnant or breastfeeding women should only use it if clearly indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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