Product image of Midazolam Kalceks (Midazolam) supplied by GNH India

Midazolam Kalceks

Active Ingredient:
Midazolam
Origin:
EU

Midazolam Kalceks (Midazolam)

Midazolam, the active ingredient in Midazolam Kalceks, is a benzodiazepine presented as a sterile injectable solution for intramuscular, intravenous, or rectal use. It provides rapid sedation, anxiolysis, and anticonvulsant effects for patients undergoing procedures, surgery, or experiencing acute seizures.

GNH India supplies Midazolam Kalceks as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide. The company adheres to stringent quality standards and regulatory requirements across global markets.

Manufacturer / TM Owner

Kalceks

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Midazolam is a benzodiazepine used in several clinical pathways to provide sedation, anxiolysis, and seizure control.

  • Procedural sedation: produces calm and pain‑free conditions for diagnostic or therapeutic procedures.
  • Pre‑operative anxiolysis: reduces anxiety before surgery and facilitates induction of anesthesia.
  • Induction of anesthesia: provides rapid onset of unconsciousness as part of an anesthetic regimen.
  • Acute seizure control: terminates prolonged seizures when administered promptly.

How It Works

  • Midazolam acts as a positive allosteric modulator at the GABA‑A receptor complex, enhancing the inhibitory effect of the neurotransmitter GABA. This increased chloride ion influx hyperpolarizes neuronal membranes, leading to reduced neuronal excitability and the clinical effects of sedation, anxiolysis, muscle relaxation, and anticonvulsant activity.

Side Effects

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Amnesia: difficulty recalling events that occurred after administration.
  • Respiratory depression: slowed breathing, especially at higher doses.
  • Hypotension: mild drop in blood pressure.
  • Nausea: feeling of stomach upset.

Serious or Rare Side Effects

  • Severe respiratory depression or apnea: potentially life‑threatening breathing cessation.
  • Paradoxical reactions: agitation, aggression, or involuntary movements.
  • Anaphylaxis: acute allergic reaction with rash, swelling, and airway compromise.
  • Cardiac arrhythmias: irregular heart rhythm requiring immediate attention.

Precautions & Warnings

Midazolam should be used with careful clinical monitoring and consideration of patient‑specific factors.

  • Assess respiratory function: monitor breathing rate and oxygen saturation continuously.
  • Avoid use in severe hepatic impairment: impaired metabolism may increase drug exposure.
  • Use caution in the elderly: increased sensitivity may lead to exaggerated sedation.
  • Concomitant CNS depressants: risk of additive sedation and respiratory depression.
  • Pregnancy and lactation: safety unknown; weigh potential benefits against risks.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Midazolam can interact with other medications, altering its effects or safety profile.

Major Interactions (Avoid)

  • Opioids: additive respiratory depression may become severe.
  • Barbiturates: profound central nervous system depression.
  • Alcohol: enhanced sedation and impaired coordination.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase plasma concentrations.
  • Antidepressants (SSRIs, SNRIs): potential for serotonin syndrome.
  • Antihistamines: increased sedation and drowsiness.

Frequently Asked Questions

Midazolam Kalceks is a sterile injectable formulation of midazolam, a benzodiazepine used for procedural sedation, pre‑operative anxiolysis, induction of anesthesia, and rapid control of acute seizures in hospital and clinical settings.

Midazolam enhances the activity of the neurotransmitter GABA at the GABA‑A receptor, increasing chloride ion flow into neurons. This hyperpolarizes the cells, reducing neuronal firing and producing sedation, anxiolysis, muscle relaxation, and anticonvulsant effects.

The dose of Midazolam Kalceks is determined by the prescribing clinician based on the patient’s age, weight, clinical condition, and the intended use. Dosing regimens are individualized and should follow local guidelines and the prescriber’s judgment.

Safety data for midazolam in pregnancy and lactation are limited, and the pregnancy category is listed as unknown. Use is only considered when the potential benefit justifies any possible risk to the fetus or infant, and it should be decided by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Midazolam is a short‑acting benzodiazepine, offering rapid onset and relatively brief duration compared with longer‑acting agents like diazepam. Its potency and ability to be administered via multiple routes (IV, IM, rectal) make it a preferred choice for procedural sedation and seizure emergencies.

Midazolam Kalceks should be stored at ambient temperature, protected from moisture and light, and kept in its original packaging until use. Do not freeze the product, and inspect the vial for particulate matter before administration.

The product is supplied as a sterile injectable solution and can be given intravenously, intramuscularly, or rectally, depending on the clinical situation. Administration is performed by qualified healthcare professionals following aseptic technique and appropriate dosing guidelines.

The most serious risks include severe respiratory depression, apnea, paradoxical reactions such as agitation, and rare anaphylactic responses. Continuous monitoring of respiratory and cardiovascular status is essential, especially when used with other central nervous system depressants.

Midazolam Kalceks is contraindicated in patients with known hypersensitivity to midazolam or any benzodiazepine, those with severe respiratory insufficiency, and individuals with acute narrow‑angle glaucoma. Caution is also advised for patients with significant hepatic impairment or a history of substance dependence.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Midazolam

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT