Product image of Miderizone (Tolperisone Hydrochloride) supplied by GNH India

Miderizone

Active Ingredient:
Tolperisone Hydrochloride
Origin:
EU

Miderizone (Tolperisone Hydrochloride)

Tolperisone Hydrochloride, the active ingredient in Miderizone, is a centrally acting skeletal muscle relaxant presented as an oral tablet for oral use. It reduces muscle spasm and associated pain in adults with musculoskeletal conditions.

GNH India supplies Miderizone as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Meditop Pharmaceutical Co. Ltd.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Tolperisone Hydrochloride is used to manage conditions involving skeletal muscle hypertonia.

  • Muscle spasm: alleviates involuntary muscle contractions and reduces associated pain.
  • Musculoskeletal pain: improves comfort by relaxing tense muscles that contribute to pain.
  • Spasticity: decreases muscle tone in disorders such as post‑stroke or multiple sclerosis.

How It Works

  • Tolperisone Hydrochloride blocks voltage‑gated sodium channels in spinal cord neurons, diminishing neuronal excitability. This action reduces the transmission of reflex arcs that maintain skeletal muscle hypertonia, leading to relaxation of overactive muscles without significant central nervous system depression.

Side Effects

Tolperisone Hydrochloride may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Dizziness: transient sensation of light‑headedness.
  • Nausea: mild stomach upset.
  • Headache: occasional mild headache.
  • Fatigue: feeling of tiredness.

Serious or Rare Side Effects

  • Hypotension: significant drop in blood pressure.
  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Hepatic dysfunction: abnormal liver enzymes or jaundice.

Precautions & Warnings

When prescribing Tolperisone Hydrochloride, clinicians should consider several safety aspects.

  • Renal impairment: adjust use if kidney function is reduced.
  • Hepatic disease: monitor liver function during therapy.
  • Cardiovascular disorders: use cautiously in patients with low blood pressure.
  • Concomitant CNS depressants: may enhance sedative effects.
  • Pregnancy and lactation: safety not established; avoid unless clearly needed.
  • Store at ambient temperature: keep below 25°C, protect from moisture and light in original packaging.

Avoid Interactions

Tolperisone Hydrochloride can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Other muscle relaxants: additive muscle weakness.
  • Antihypertensive agents: may potentiate blood pressure lowering.
  • CYP450 inhibitors (e.g., erythromycin): could increase plasma levels.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): enhanced sedation.
  • Anticholinergic drugs: possible increase in anticholinergic burden.
  • Diuretics: monitor electrolyte balance.

Frequently Asked Questions

Miderizone, containing Tolperisone Hydrochloride, is prescribed to relieve muscle spasm, reduce musculoskeletal pain, and manage spasticity associated with neurological disorders such as stroke or multiple sclerosis.

Tolperisone Hydrochloride blocks voltage‑gated sodium channels in spinal cord neurons, lowering neuronal excitability and interrupting reflex pathways that cause excessive muscle tone, thereby producing muscle relaxation.

The dosage of Miderizone is individualized; the prescribing clinician determines the appropriate amount and schedule based on the patient’s condition, response, and overall health profile.

Safety data for Tolperisone Hydrochloride in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under medical supervision.

To order Miderizone, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with many centrally acting relaxants, Tolperisone Hydrochloride has a lower propensity for sedation because it primarily blocks peripheral sodium channels, making it a useful alternative when reduced drowsiness is desired.

Miderizone should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the container tightly closed and out of reach of children.

Miderizone is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks, though rare, include significant hypotension, severe allergic reactions such as rash or breathing difficulty, and hepatic dysfunction indicated by abnormal liver enzymes or jaundice. Patients should seek immediate medical attention if these occur.

Miderizone is contraindicated in patients with known hypersensitivity to Tolperisone Hydrochloride or any excipients, and it should be used with caution or avoided in individuals with severe liver or kidney impairment, uncontrolled low blood pressure, or those taking multiple other muscle relaxants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Tolperisone Hydrochloride

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT