Product image of Midiana (Drospirenone, Ethinylestradiol) supplied by GNH India

Midiana

Active Ingredient:
Drospirenone, Ethinylestradiol
Origin:
EU

Midiana (Drospirenone, Ethinylestradiol)

Drospirenone/Ethinylestradiol, the active ingredient in Midiana, is a combined oral contraceptive presented as a tablet for oral use. It prevents pregnancy in women of reproductive age by inhibiting ovulation and altering cervical mucus.

GNH India supplies Midiana as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

  • Midiana, a combined oral contraceptive, acts on the hypothalamic‑pituitary‑ovarian axis to prevent conception.
  • Prevention of pregnancy: provides reliable contraceptive protection for women of childbearing potential.
  • Menstrual cycle regulation: helps establish a regular 28‑day cycle and reduces heavy menstrual bleeding.
  • Acne management: may improve mild to moderate acne associated with hormonal fluctuations.

How It Works

  • Drospirenone and ethinylestradiol bind to progesterone and estrogen receptors, respectively, suppressing the mid‑cycle surge of luteinising hormone (LH) and follicle‑stimulating hormone (FSH). This inhibition prevents ovulation. In addition, the progestogenic component thickens cervical mucus and the estrogen component stabilises the endometrium, reducing the chance of fertilisation and implantation.

Side Effects

Common Side Effects

  • Nausea or upset stomach
  • Breast tenderness or enlargement
  • Headache or migraine
  • Weight gain or fluid retention
  • Mood changes or irritability
  • Spotting or breakthrough bleeding

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism
  • Stroke or transient ischemic attack
  • Myocardial infarction
  • Severe allergic reaction (anaphylaxis)
  • Liver dysfunction or jaundice
  • Vision changes or eye pain

Precautions & Warnings

Before prescribing Midiana, clinicians should consider several safety factors.

  • Contraindications: known thrombophilia, estrogen‑dependent tumor, active liver disease, or confirmed pregnancy.
  • Smoking: avoid use in women over 35 who smoke due to increased thrombotic risk.
  • Blood pressure: monitor patients with hypertension; uncontrolled high BP is a contraindication.
  • Drug interactions: review concomitant medications that may alter hormone levels.
  • Regular follow‑up: schedule periodic assessments to evaluate efficacy and tolerability.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Avoid Interactions

Midiana may interact with several medicines that affect hormone metabolism.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine) can markedly reduce contraceptive effectiveness.
  • Protease inhibitors (e.g., ritonavir) may increase the risk of thrombotic events.
  • Concurrent use with other estrogen‑containing products (e.g., hormone replacement therapy) can raise estrogen exposure.

Moderate Interactions (Monitor Closely)

  • Antifungal agents such as ketoconazole may increase plasma concentrations of ethinylestradiol.
  • Selective serotonin reuptake inhibitors (SSRIs) can modestly increase bleeding risk.
  • Diuretics may affect fluid balance and blood pressure, requiring closer monitoring.

Frequently Asked Questions

Midiana is a combined oral contraceptive containing drospirenone and ethinylestradiol. It is prescribed to prevent pregnancy in women of reproductive age by inhibiting ovulation and creating an environment that is unfavorable for fertilisation and implantation.

Drospirenone acts as a progestogen, while ethinylestradiol is an estrogen. Together they suppress the mid‑cycle surge of luteinising hormone and follicle‑stimulating hormone, preventing ovulation. The progestogen also thickens cervical mucus and the estrogen stabilises the endometrium, reducing the chance of fertilisation and implantation.

The dosing regimen for Midiana is determined by the prescribing clinician. Typically, it is taken as a daily tablet according to a specific cycle, but the exact strength, number of tablets per pack, and duration are set by the healthcare provider based on individual needs.

Midiana is contraindicated during pregnancy because it is intended to prevent conception. If pregnancy occurs, the product should be discontinued. Limited data are available for breastfeeding; clinicians usually advise against use while nursing unless the benefits outweigh potential risks.

To place an order, submit an enquiry on the Midiana product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Midiana contains drospirenone, a progestogen with anti‑androgenic and mild diuretic properties, which may offer advantages such as reduced water retention compared with some other progestins. Its efficacy in preventing pregnancy is comparable to other combined oral contraceptives, while the side‑effect profile may differ slightly.

Midiana tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Midiana is taken orally, usually once daily at the same time each day. The tablets are swallowed whole with water and are not to be split, crushed, or chewed. Patients should follow the specific cycle schedule provided by their prescriber.

The most serious risks include venous thromboembolism (deep vein thrombosis, pulmonary embolism), arterial events such as stroke or myocardial infarction, and severe allergic reactions. Women with a history of clotting disorders, smoking over age 35, or certain cardiovascular conditions should avoid use.

Midiana is contraindicated in women who are pregnant, have known thrombophilia, a history of estrogen‑dependent tumors, uncontrolled hypertension, active liver disease, or who are smokers over the age of 35. It should also be avoided in individuals with known hypersensitivity to any component of the tablet.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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