Product image of Midiana (Drospirenone, Ethinylestradiol) supplied by GNH India

Midiana

Active Ingredient:
Drospirenone, Ethinylestradiol
Origin:
EU

Midiana (Drospirenone, Ethinylestradiol)

Drospirenone/Ethinylestradiol, the active ingredients in Midiana, are a combined oral contraceptive presented as a tablet for oral use. They prevent pregnancy in women of reproductive age by inhibiting ovulation, thickening cervical mucus, and altering the endometrial lining to reduce the chance of implantation.

GNH India supplies Midiana as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies, and clinics worldwide while adhering to stringent quality standards and regulatory requirements, and supporting healthcare professionals with reliable supply chain solutions.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

  • Midiana, a combined oral contraceptive, is used to prevent pregnancy by modulating hormonal pathways that regulate the menstrual cycle.
  • Pregnancy prevention: provides reliable contraception for women of childbearing age
  • Menstrual cycle regulation: helps achieve more predictable menstrual bleeding patterns
  • Acne improvement: may reduce acne associated with androgenic activity in some users

How It Works

  • Midiana combines drospirenone, a synthetic progestogen with anti‑mineralocorticoid and anti‑androgenic properties, and ethinylestradiol, a synthetic estrogen. The estrogen component suppresses follicle‑stimulating hormone, while drospirenone inhibits luteinizing hormone surge, together preventing ovulation. Additionally, the progestogen thickens cervical mucus and induces endometrial changes that reduce the likelihood of implantation. These combined actions maintain a hormonal environment that mimics the luteal phase, providing effective contraception throughout the monthly cycle.

Side Effects

Midiana may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea: mild gastrointestinal upset
  • Breast tenderness: swelling or discomfort
  • Headache: mild to moderate
  • Irregular bleeding or spotting: changes in menstrual flow

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism
  • Arterial thrombosis: stroke or myocardial infarction
  • Severe allergic reaction: anaphylaxis or angioedema

Precautions & Warnings

  • When prescribing Midiana, consider the following precautions.
  • Contraindications: known history of thromboembolic disorders, estrogen‑dependent tumors, or active liver disease
  • Smoking: avoid use in women over 35 who smoke
  • Cardiovascular risk: assess hypertension and hyperlipidemia before prescribing
  • Pregnancy: discontinue immediately if pregnancy is confirmed
  • Breastfeeding: consult healthcare provider before use
  • Store at ambient temperature: keep in original packaging, protect from moisture and light

Avoid Interactions

Midiana can interact with other medicines; some require avoidance while others need monitoring.

Major Interactions (Avoid)

  • Enzyme inducers (e.g., rifampin, carbamazepine, phenytoin) may reduce contraceptive efficacy
  • Antifungal agents such as ketoconazole or itraconazole may increase hormone levels leading to toxicity

Moderate Interactions (Monitor Closely)

  • SSRIs (e.g., fluoxetine) may increase risk of mood changes
  • Antihypertensives (e.g., ACE inhibitors) may have altered blood pressure control
  • Diuretics (e.g., thiazides) may increase potassium loss when combined with drospirenone

Frequently Asked Questions

Midiana is a combined oral contraceptive containing drospirenone and ethinylestradiol, prescribed to prevent pregnancy in women of reproductive age. It works by inhibiting ovulation and creating cervical mucus changes that reduce the chance of fertilization.

The ethinylestradiol component suppresses the pituitary release of follicle‑stimulating hormone, while drospirenone blocks the luteinizing hormone surge, together preventing ovulation. Drospirenone also thickens cervical mucus and alters the endometrial lining, making implantation unlikely.

The dosage regimen for Midiana is determined by the prescribing healthcare professional. Typically, it is taken as one tablet daily at the same time each day for a 21‑day active phase followed by a hormone‑free interval, but the exact schedule must follow the prescriber’s instructions.

Midiana is intended for use only when pregnancy is not present. If pregnancy occurs, the product should be discontinued and alternative contraception considered. Use during breastfeeding should be discussed with a healthcare provider, as hormonal contraceptives may affect milk production and infant exposure.

To place an order, submit an enquiry on the Midiana product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Midiana contains drospirenone, which has anti‑mineralocorticoid and anti‑androgenic properties, potentially offering benefits such as reduced water retention and improvement in acne compared with formulations containing other progestins. Efficacy in preventing pregnancy is comparable across approved combined oral contraceptives, while side‑effect profiles may differ.

Midiana tablets should be stored at ambient temperature, below 25 °C, in the original blister pack to protect from moisture and light. Keep the medication out of reach of children and do not use after the expiration date.

Midiana is taken orally, usually once daily at the same time each day. The tablets are swallowed whole with water and should not be chewed or broken. Adherence to the daily schedule is important for maintaining contraceptive effectiveness.

The most serious risks include venous thromboembolism (deep‑vein thrombosis or pulmonary embolism), arterial thrombosis (stroke or myocardial infarction), and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience symptoms such as unexplained leg pain, chest pain, severe headache, or signs of an allergic reaction.

Midiana is contraindicated in women with a history of thromboembolic events, estrogen‑dependent tumors, active liver disease, uncontrolled hypertension, or known hypersensitivity to any component. It should also be avoided by smokers over the age of 35 and by anyone who is currently pregnant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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