Product image of Midiana (Drospirenone, Ethinylestradiol) supplied by GNH India

Midiana

Active Ingredient:
Drospirenone, Ethinylestradiol
Origin:
EU

Midiana (Drospirenone, Ethinylestradiol)

Drospirenone, the active ingredient in Midiana, is a combined oral contraceptive presented as an oral tablet for oral use. It prevents pregnancy by suppressing ovulation and altering cervical mucus and endometrial development in women of reproductive age.

GNH India supplies Midiana as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

Midiana, a combined oral contraceptive, is indicated for hormonal contraception in women.

  • Prevention of pregnancy: provides reliable contraceptive protection when taken as directed.
  • Regulation of menstrual cycles: helps achieve more predictable bleeding patterns.
  • Treatment of moderate acne: can improve acne associated with hormonal fluctuations.

How It Works

  • Drospirenone and ethinylestradiol act together to suppress the hypothalamic‑pituitary‑ovarian axis, inhibiting the mid‑cycle surge of luteinising hormone (LH) and follicle‑stimulating hormone (FSH). This prevents ovulation. The estrogen component stabilises the endometrium, while the progestin component thickens cervical mucus and induces endometrial changes that are unfavorable for implantation.

Side Effects

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Breast tenderness: discomfort or swelling of the breasts.
  • Headache: occasional tension‑type headaches.
  • Weight gain: slight increase in body weight.
  • Mood changes: irritability or mood swings.
  • Spotting: irregular breakthrough bleeding.

Serious or Rare Side Effects

  • Venous thromboembolism: deep‑vein thrombosis or pulmonary embolism.
  • Arterial thrombosis: stroke or myocardial infarction.
  • Hypertension: new‑onset or worsening high blood pressure.
  • Liver disorders: cholestatic jaundice or hepatic dysfunction.
  • Gallbladder disease: gallstones or cholecystitis.
  • Severe allergic reactions: anaphylaxis, angioedema, or skin rash.

Precautions & Warnings

Midiana should be used with caution in the following situations:

  • Pregnancy: contraindicated; avoid use during pregnancy.
  • Smoking: especially >15 cigarettes/day in women >35 years.
  • History of thromboembolism: increased risk of clot formation.
  • Liver disease: impaired metabolism may alter drug levels.
  • Hypertension: monitor blood pressure regularly.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Midiana may interact with several medicines that affect its efficacy or safety.

Major Interactions (Avoid)

  • Rifampin: strong CYP3A4 inducer that reduces contraceptive effectiveness.
  • Carbamazepine: enzyme inducer that may lead to contraceptive failure.
  • Phenytoin: reduces plasma levels of hormonal components.
  • St. John's wort: herbal inducer that can diminish contraceptive protection.

Moderate Interactions (Monitor Closely)

  • Ketoconazole: CYP3A4 inhibitor that may increase hormone concentrations.
  • Erythromycin: macrolide antibiotic that can raise ethinylestradiol levels.
  • Fluoxetine: SSRI that may slightly elevate hormone exposure.
  • NSAIDs: may increase risk of hypertension when used long‑term.

Frequently Asked Questions

Midiana is a combined oral contraceptive indicated for the prevention of pregnancy in women of reproductive age. It is also prescribed to help regulate menstrual cycles and may be used to treat moderate acne associated with hormonal fluctuations.

The combination of drospirenone and ethinylestradiol suppresses the release of luteinising hormone and follicle‑stimulating hormone, preventing ovulation. Drospirenone also thickens cervical mucus and alters the endometrium, creating conditions that are unfavorable for fertilisation and implantation.

The dosing regimen for Midiana is determined by the prescribing healthcare professional. Typically, it is taken once daily at the same time each day, but the exact schedule and duration are set by the prescriber based on individual patient needs.

Midiana is contraindicated in pregnancy (Category X) and should not be started or continued if a woman becomes pregnant. It is generally not recommended during breastfeeding because hormonal contraceptives can affect milk production and infant exposure.

To order Midiana, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Midiana contains drospirenone, a progestin with anti‑androgenic and mild diuretic properties, which may offer benefits such as reduced water retention and improved acne control compared with older progestins. Its efficacy in preventing pregnancy is comparable to other combined oral contraceptives when taken correctly.

Midiana tablets should be stored at temperatures below 25 °C, in the original packaging, protected from moisture and direct sunlight. Keep the container tightly closed and out of reach of children.

Midiana is taken orally, usually as a single tablet each day at the same time. It is important to follow the prescriber’s instructions and to start a new pack after a 7‑day hormone‑free interval, unless directed otherwise.

Serious risks include venous thromboembolism, arterial thrombosis (such as stroke or myocardial infarction), severe hypertension, liver disorders, and rare allergic reactions. Patients should seek immediate medical attention if they experience symptoms such as unexplained leg pain, chest pain, severe headache, or signs of an allergic reaction.

Midiana should not be used by women who are pregnant, have a history of thromboembolic disorders, uncontrolled hypertension, severe liver disease, known or suspected breast cancer, or who smoke heavily (more than 15 cigarettes per day) and are over 35 years old. It is also contraindicated in individuals with known hypersensitivity to any component of the product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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