Product image of Midiana (Drospirenone, Ethinylestradiol) supplied by GNH India

Midiana

Active Ingredient:
Drospirenone, Ethinylestradiol
Origin:
EU

Midiana (Drospirenone, Ethinylestradiol)

Drospirenone, the active ingredient in Midiana, is a combined oral contraceptive presented as an oral tablet for oral use. It prevents pregnancy by suppressing ovulation, thickening cervical mucus, and altering the endometrium in women of reproductive age, and is formulated for once‑daily administration as a reliable method of contraception.

GNH India supplies Midiana as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing quality‑assured products that meet European Union regulatory standards, and supports timely delivery to global markets.

Manufacturer / TM Owner

Gedeon Richter Plc.

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Indications & Clinical Uses

  • Midiana, a combined oral contraceptive, acts on the hormonal regulation pathway to prevent pregnancy.
  • Prevention of pregnancy: provides reliable contraceptive protection for women of childbearing potential.
  • Regulation of menstrual cycle: helps achieve more predictable bleeding patterns and reduces cycle irregularities.
  • Management of dysmenorrhea: may lessen menstrual pain associated with ovulatory cycles.

How It Works

  • Drospirenone is a synthetic progestogen with anti‑mineralocorticoid and anti‑androgenic activity, while ethinylestradiol is a synthetic estrogen. Together they suppress the hypothalamic‑pituitary‑ovarian axis, lowering luteinizing hormone and follicle‑stimulating hormone release, which prevents follicular development and ovulation. The progestogenic component also thickens cervical mucus, creating a barrier to sperm, and induces endometrial changes that reduce the likelihood of implantation.

Side Effects

Midiana may cause a range of adverse reactions, which are classified by frequency.

Common Side Effects

  • Nausea
  • Breast tenderness
  • Headache
  • Weight gain
  • Breakthrough bleeding

Serious or Rare Side Effects

  • Venous thromboembolism (deep‑vein thrombosis, pulmonary embolism)
  • Arterial thrombosis (stroke, myocardial infarction)
  • Severe hypertension
  • Hepatocellular adenoma (liver tumor)
  • Allergic reactions (rash, angioedema)

Precautions & Warnings

  • Before prescribing Midiana, clinicians should consider several safety factors.
  • Pregnancy contraindication: do not use during pregnancy; discontinue immediately if pregnancy occurs.
  • Smoking restriction: avoid use in women over 35 who smoke due to increased cardiovascular risk.
  • Cardiovascular assessment: evaluate history of thromboembolic disorders before initiating therapy.
  • Liver disease: use with caution in patients with active liver disease or hepatic dysfunction.
  • Blood pressure monitoring: check blood pressure regularly during treatment.
  • Store at room temperature: keep below 25°C in the original packaging, protect from moisture.

Avoid Interactions

Midiana can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin): reduce contraceptive efficacy.
  • Certain antiretrovirals (e.g., protease inhibitors boosted with ritonavir): may lower hormone levels.
  • St. John’s wort: may markedly decrease plasma concentrations of the hormones.

Moderate Interactions (Monitor Closely)

  • Antifungal agents (e.g., ketoconazole, itraconazole): may increase hormone exposure.
  • Macrolide antibiotics (e.g., erythromycin, clarithromycin): can elevate plasma levels.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine, sertraline): may modestly affect hormone metabolism.

Frequently Asked Questions

Midiana is a combined oral contraceptive containing drospirenone and ethinylestradiol. It is prescribed to prevent pregnancy in women of reproductive age and may also help regulate menstrual cycles and reduce menstrual discomfort. It works as a hormonal method of birth control taken orally.

Drospirenone provides progestogenic activity with anti‑mineralocorticoid and anti‑androgenic effects, while ethinylestradiol supplies estrogenic activity. Together they suppress the hypothalamic‑pituitary‑ovarian axis, lowering LH and FSH, which prevents ovulation. The progestin also thickens cervical mucus and alters the endometrium, creating conditions that inhibit sperm penetration and implantation.

The dosage regimen for Midiana is set by the prescribing healthcare professional. Typically the product is taken once daily at the same time each day, but the exact strength, tablet count and duration are determined by the prescriber based on individual patient needs.

Midiana is contraindicated in pregnancy and should be discontinued if pregnancy is confirmed. Use during breastfeeding is generally not recommended unless the benefits outweigh the risks; clinicians should discuss individual circumstances with the patient and consider alternative contraception if needed.

To order Midiana, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Midiana offers efficacy comparable to other combined oral contraceptives. Its drospirenone component provides anti‑mineralocorticoid activity, which may result in a lower risk of water retention and a different side‑effect profile compared with products containing other progestins. Safety, tolerability and individual patient factors guide the choice of one COC over another.

Midiana tablets should be stored at room temperature, below 25 °C. Keep them in the original blister pack, protect from moisture and direct heat, and keep out of reach of children. Do not use the product after the expiry date printed on the packaging.

Midiana is taken orally as a tablet once daily, preferably at the same time each day. It may be taken with or without food. Consistent daily intake helps maintain effective hormone levels for reliable contraception.

The most serious risks include venous thromboembolism (deep‑vein thrombosis, pulmonary embolism), arterial thrombosis (stroke, myocardial infarction), severe hypertension, and rare liver tumors such as hepatocellular adenoma. Patients should seek immediate medical attention if they experience unexplained leg pain, chest pain, severe headache, visual changes, or abdominal pain.

Midiana should not be used by women who are pregnant, have a history of thromboembolic disease, uncontrolled hypertension, certain liver disorders, known hypersensitivity to drospirenone, ethinylestradiol or any excipients, or who are smokers over the age of 35. A thorough medical assessment is required before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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