Product image of Midodrin Evolan (Midodrine Hydrochloride) supplied by GNH India

Midodrin Evolan

Active Ingredient:
Midodrine Hydrochloride
Origin:
EU

Midodrin Evolan (Midodrine Hydrochloride)

Midodrine Hydrochloride, the active ingredient in Midodrin Evolan, is a Alpha-1 adrenergic agonist presented as an oral tablet for oral use. It treats orthostatic hypotension in adults by raising standing blood pressure and reducing dizziness or fainting episodes.

GNH India supplies Midodrin Evolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

Midodrine Hydrochloride is used to manage conditions related to low blood pressure by activating peripheral alpha‑1 adrenergic receptors.

  • Orthostatic hypotension: Increases standing blood pressure and reduces symptoms such as dizziness, light‑headedness, or syncope.

How It Works

  • Midodrine Hydrochloride is a pro‑drug that is rapidly converted to desglymidodrine, an active metabolite that selectively stimulates peripheral alpha‑1 adrenergic receptors. This stimulation causes vasoconstriction of arterioles and veins, thereby increasing systemic vascular resistance and raising arterial blood pressure.

Side Effects

Midodrine Hydrochloride may cause a range of adverse reactions. Most are mild and reversible.

Common Side Effects

  • Headache: mild to moderate pressure sensation.
  • Supine hypertension: elevated blood pressure when lying down.
  • Piloerection: localized goose‑flesh skin reaction.
  • Nausea: occasional stomach upset.

Serious or Rare Side Effects

  • Severe hypertension: rapid, high rise in blood pressure requiring medical attention.
  • Bradycardia: unusually slow heart rate.
  • Myocardial ischemia: chest pain or heart attack symptoms.
  • Allergic reactions: rash, itching, or swelling.
  • Angioedema: swelling of face, lips, or throat.

Precautions & Warnings

Before prescribing Midodrine Hydrochloride, clinicians should consider several safety measures.

  • Dose titration: adjust based on individual blood pressure response.
  • Supine hypertension monitoring: avoid lying flat soon after dosing.
  • Renal impairment: use with caution in patients with reduced kidney function.
  • Cardiovascular disease: assess risk of excessive pressor effect.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Midodrine Hydrochloride can interact with other agents that affect blood pressure or sympathetic activity.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Tricyclic antidepressants: additive pressor effect.
  • Sympathomimetic agents: excessive hypertension.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypotensive effect.
  • Beta‑blockers: may blunt compensatory tachycardia.
  • ACE inhibitors: possible variability in blood pressure control.

Frequently Asked Questions

Midodrin Evolan contains midodrine hydrochloride and is prescribed to raise blood pressure in patients with orthostatic hypotension, helping to prevent dizziness, light‑headedness, and fainting when standing.

Midodrine is a pro‑drug that is converted to desglymidodrine, which selectively activates peripheral alpha‑1 adrenergic receptors. This causes blood vessels to constrict, increasing vascular tone and raising systemic blood pressure.

The dosage of Midodrin Evolan is determined by the prescribing clinician based on the patient’s blood pressure response, severity of symptoms, and overall health status. No fixed regimen is provided here.

Safety data for midodrine hydrochloride in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant, and under medical supervision.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Midodrine is an oral alpha‑1 agonist that directly raises vascular tone, whereas alternatives such as fludrocortisone increase blood volume, and droxidopa is a norepinephrine precursor. Choice depends on patient tolerance, comorbidities, and physician preference.

Store at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging is tightly closed.

Midodrin Evolan is taken orally as a tablet, usually with a full glass of water. It is commonly administered during the day and avoided close to bedtime to reduce the risk of supine hypertension.

The most serious risks include severe hypertension, especially when lying down, bradycardia, myocardial ischemia, and rare allergic reactions such as angioedema. Patients should be monitored for these events, particularly after dose adjustments.

Midodrin Evolan should be avoided in patients with severe organic heart disease, acute renal failure, or uncontrolled hypertension. It is also contraindicated in individuals who have experienced hypersensitivity to midodrine or any of its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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