Product image of Midodrine Arrow (Midodrine Hydrochloride) supplied by GNH India

Midodrine Arrow

Active Ingredient:
Midodrine Hydrochloride
Origin:
EU

Midodrine Arrow (Midodrine Hydrochloride)

Midodrine Hydrochloride, the active ingredient in Midodrine Arrow, is an alpha‑adrenergic agonist presented as an oral formulation for oral use. It raises standing blood pressure in patients who experience orthostatic hypotension, helping to reduce dizziness and fainting episodes associated with the condition.

GNH India supplies Midodrine Arrow as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Arrow Generiques

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Indications & Clinical Uses

  • Midodrine Arrow is an alpha‑adrenergic agonist used to treat disorders of low blood pressure that occur on standing.
  • Orthostatic hypotension: improves standing systolic pressure and reduces symptoms of dizziness.
  • Neurogenic orthostatic hypotension: increases vascular tone in patients with autonomic failure, helping maintain cerebral perfusion.

How It Works

  • Midodrine Hydrochloride is converted in the body to desglymidodrine, which selectively stimulates peripheral alpha‑1 adrenergic receptors on vascular smooth muscle. This activation causes vasoconstriction, increasing systemic vascular resistance and thereby raising arterial blood pressure, particularly when a patient moves to an upright position.

Side Effects

Midodrine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Piloerection (goose‑skin appearance)
  • Pruritus (itching)
  • Urinary retention
  • Supine hypertension
  • Headache
  • Nausea

Serious or Rare Side Effects

  • Severe hypertension, especially when lying down
  • Bradycardia or arrhythmia
  • Ischemic cardiac events
  • Allergic reactions such as rash or angioedema
  • Peripheral ischemia leading to tissue damage

Precautions & Warnings

Before prescribing Midodrine, clinicians should consider several safety measures.

  • Blood pressure monitoring: check supine and standing pressures regularly.
  • Supine positioning: advise patients to avoid lying flat for prolonged periods.
  • Cardiovascular disease: use caution in patients with coronary artery disease or heart failure.
  • Renal/hepatic impairment: assess function and adjust therapy if needed.
  • Contraindicated in pheochromocytoma or severe organic heart disease.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Midodrine can interact with other medications that affect blood pressure.

Major Interactions (Avoid)

  • Other alpha‑adrenergic agonists (e.g., phenylephrine) – additive hypertensive effect.
  • Monoamine oxidase inhibitors – risk of excessive vasoconstriction.
  • Direct vasopressors (e.g., norepinephrine) – may cause severe hypertension.

Moderate Interactions (Monitor Closely)

  • Diuretics – may amplify blood pressure changes.
  • Antihypertensive agents (ACE inhibitors, ARBs, beta‑blockers) – may reduce therapeutic effect.
  • Tricyclic antidepressants – potential for increased vascular tone.

Frequently Asked Questions

Midodrine Arrow contains midodrine hydrochloride, an alpha‑adrenergic agonist prescribed to treat orthostatic hypotension. It helps increase standing blood pressure, reducing dizziness, light‑headedness, and the risk of fainting when patients change from a lying to a standing position.

Midodrine is converted in the body to an active metabolite that selectively stimulates peripheral alpha‑1 adrenergic receptors. This activation causes blood vessels to constrict, raising systemic vascular resistance and thereby increasing arterial pressure, especially during upright posture.

The appropriate dose of Midodrine Arrow is determined by the prescribing clinician based on the individual’s blood‑pressure response, severity of symptoms, and overall health status. Dosage adjustments are made according to clinical monitoring.

Safety data for midodrine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Midodrine is a direct alpha‑1 agonist, whereas other agents such as fludrocortisone increase blood volume, and droxidopa is a prodrug that raises norepinephrine levels. Midodrine’s rapid onset and short half‑life make it useful for acute symptom control, but it may require careful monitoring for supine hypertension.

Midodrine Arrow should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability and potency.

Midodrine Arrow is taken orally, usually with a full glass of water. It is commonly administered during the daytime, and patients are advised to avoid taking the last dose at least four hours before lying down to reduce the risk of supine hypertension.

The most serious risks include severe supine hypertension, which can lead to cardiovascular complications, and rare cases of peripheral ischemia. Patients should be educated to monitor blood pressure while lying down and report any signs of chest pain, shortness of breath, or limb discoloration.

Midodrine Arrow is contraindicated in patients with known pheochromocytoma, severe organic heart disease, or uncontrolled hypertension. It should also be avoided in individuals who have experienced severe allergic reactions to midodrine or any of its excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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