Product image of Midodrine Hydrochloride Strandhaven (Midodrine Hydrochloride) supplied by GNH India

Midodrine Hydrochloride Strandhaven

Active Ingredient:
Midodrine Hydrochloride
Origin:
EU

Midodrine Hydrochloride Strandhaven (Midodrine Hydrochloride)

Midodrine Hydrochloride, the active ingredient in Midodrine Hydrochloride Strandhaven, is an Alpha-1 adrenergic agonist presented as an oral tablet for oral use. It treats orthostatic hypotension and symptomatic hypotension in adults who experience low blood pressure upon standing.
GNH India supplies Midodrine Hydrochloride Strandhaven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Strandhaven Limited T/A Somex Pharma

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Indications & Clinical Uses

Midodrine Hydrochloride is an alpha‑1 adrenergic agonist used to manage conditions related to low blood pressure.

  • Orthostatic hypotension: improves standing blood pressure and reduces dizziness.
  • Symptomatic hypotension: raises systemic blood pressure in patients with symptomatic low pressure.
  • Postural hypotension: helps maintain cerebral perfusion when changing posture.

How It Works

  • Midodrine Hydrochloride is a prodrug that is rapidly converted to desglymidodrine, an active metabolite that selectively stimulates peripheral alpha‑1 adrenergic receptors. Activation of these receptors induces vasoconstriction of arterioles and veins, thereby increasing peripheral vascular resistance and elevating arterial blood pressure.

Side Effects

Midodrine Hydrochloride may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Piloerection (goose‑flesh skin).
  • Pruritus (itching).
  • Urinary retention.
  • Supine hypertension.
  • Headache.
  • Nausea.

Serious or Rare Side Effects

  • Severe hypertension, especially when lying down.
  • Cardiac arrhythmias.
  • Angina pectoris or myocardial infarction.
  • Ischemic stroke.
  • Severe urinary retention requiring catheterisation.
  • Peripheral ischemia of the extremities.

Precautions & Warnings

Before prescribing Midodrine Hydrochloride, clinicians should consider several safety measures.

  • Monitor blood pressure: check supine and standing values regularly.
  • Avoid use in severe cardiac disease: risk of excessive hypertension.
  • Caution in renal impairment: dose adjustment may be required.
  • Review concomitant antihypertensives: may potentiate blood‑pressure changes.
  • Store at room temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Midodrine Hydrochloride can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Other vasoconstrictors (e.g., phenylephrine): may cause severe hypertension.
  • Monoamine oxidase inhibitors (MAOIs): can amplify pressor response.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance orthostatic blood‑pressure changes.
  • ACE inhibitors or ARBs: may blunt therapeutic effect.
  • NSAIDs: can affect renal handling of blood pressure.

Frequently Asked Questions

Midodrine Hydrochloride Strandhaven is prescribed to raise blood pressure in patients who experience orthostatic or symptomatic hypotension. It is particularly useful for adults who develop dizziness, light‑headedness, or fainting when standing due to insufficient vascular tone.

Midodrine is a prodrug that is converted in the body to desglymidodrine. This active metabolite binds to peripheral alpha‑1 adrenergic receptors, causing vasoconstriction of blood vessels, which increases peripheral resistance and elevates arterial blood pressure.

The dosage of Midodrine Hydrochloride Strandhaven is individualized by the prescribing clinician based on the patient’s blood‑pressure response and tolerability. The prescriber determines the starting dose, titration schedule, and maximum daily amount.

Safety data for Midodrine Hydrochloride in pregnancy and lactation are limited, and the pregnancy category is listed as unknown. Use is only considered when the potential benefit justifies any potential risk to the fetus or infant.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

The primary alternative for orthostatic hypotension is fludrocortisone, a mineralocorticoid that expands plasma volume. Midodrine raises blood pressure by vasoconstriction rather than fluid retention, offering a different side‑effect profile and rapid onset, which may be preferable for patients where volume expansion is undesirable.

Midodrine Hydrochloride Strandhaven should be stored at room temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, excessive heat, and direct sunlight to maintain potency.

The medication is taken orally, usually with a full glass of water. It is commonly administered during the day, and patients are advised to avoid taking it within four hours of lying down to reduce the risk of supine hypertension.

The most serious risks include supine hypertension, which can lead to cardiovascular events such as stroke or myocardial infarction, and severe urinary retention that may require catheterisation. Patients should be monitored closely for these complications.

Midodrine is contraindicated in patients with severe organic heart disease, uncontrolled hypertension, or a history of ischemic cardiac events. It should also be avoided in individuals with urinary retention that cannot be managed medically.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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