Product image of Midodrine Hydrochloride Teva (Midodrine Hydrochloride) supplied by GNH India

Midodrine Hydrochloride Teva

Active Ingredient:
Midodrine Hydrochloride
Origin:
EU

Midodrine Hydrochloride Teva (Midodrine Hydrochloride)

Midodrine, the active ingredient in Midodrine Hydrochloride Teva, is an Alpha-1 adrenergic agonist presented as an oral tablet for systemic use. It is indicated for the management of orthostatic hypotension, a condition characterized by a significant fall in blood pressure upon standing, and works by increasing vascular tone to raise standing blood pressure in affected patients.

GNH India supplies Midodrine Hydrochloride Teva as a licensed, GDP-compliant product sourced from the EU market, providing reliable access to hospitals, pharmacies and clinics worldwide through its international distribution network.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Midodrine is an antihypotensive agent used to treat conditions involving low blood pressure.

  • Orthostatic hypotension: improves standing blood pressure and reduces dizziness.
  • Neurogenic orthostatic hypotension: raises vascular tone in patients with autonomic failure.
  • Symptomatic hypotension: alleviates symptoms caused by acute drops in blood pressure.

How It Works

  • Midodrine is a prodrug that is rapidly converted to desglymidodrine, an active metabolite that selectively stimulates alpha‑1 adrenergic receptors on vascular smooth muscle. This activation induces vasoconstriction, increasing peripheral vascular resistance and thereby elevating systolic and diastolic blood pressure, especially in the upright position.

Side Effects

Midodrine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Piloerection (goose‑skin appearance).
  • Pruritus (itching).
  • Urinary retention.
  • Supine hypertension.
  • Paresthesia (tingling sensations).
  • Headache.

Serious or Rare Side Effects

  • Severe hypertension, especially when lying down.
  • Bradycardia or other arrhythmias.
  • Myocardial ischemia or chest pain.
  • Allergic reactions such as rash or angioedema.
  • Syncope due to abrupt blood pressure changes.

Precautions & Warnings

Before prescribing Midodrine, clinicians should consider several safety factors.

  • Blood pressure monitoring: check supine and standing readings regularly.
  • Supine hypertension: avoid dosing within 4 hours of bedtime.
  • Renal impairment: adjust use in patients with severe kidney dysfunction.
  • Concomitant vasopressors: use with caution to prevent excessive hypertension.
  • Elderly patients: start at low dose and titrate slowly.
  • Store at ambient temperature: keep below 25 °C, in the original packaging, protected from moisture.

Avoid Interactions

Midodrine can interact with several medication classes, requiring vigilance.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other alpha‑1 agonists: additive vasoconstrictive effect.
  • Tricyclic antidepressants: may potentiate blood pressure rise.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance orthostatic hypotension when combined.
  • Antihypertensive agents (ACE inhibitors, ARBs, beta‑blockers): monitor for excessive blood pressure lowering.
  • Selective serotonin reuptake inhibitors (SSRIs): observe for blood pressure fluctuations.

Frequently Asked Questions

Midodrine Hydrochloride Teva is prescribed to treat orthostatic hypotension, a condition where blood pressure falls significantly upon standing. By raising standing blood pressure, it helps reduce dizziness, light‑headedness, and fainting episodes in patients with this disorder.

Midodrine is a prodrug that is converted to desglymidodrine, which selectively activates alpha‑1 adrenergic receptors on blood vessels. This activation causes vasoconstriction, increasing peripheral resistance and thereby elevating blood pressure, especially when a patient moves to an upright position.

The dosage of Midodrine Hydrochloride Teva is individualized by the prescribing clinician based on the patient’s blood pressure response, severity of symptoms, and tolerability. The prescriber determines the appropriate strength, frequency, and duration of therapy.

The safety of Midodrine Hydrochloride Teva in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Midodrine is unique as an oral alpha‑1 adrenergic agonist that directly increases vascular tone. Other antihypotensive options, such as fludrocortisone, act by expanding blood volume. Choice of therapy depends on patient-specific factors, including comorbidities, side‑effect profile, and clinician preference.

Midodrine Hydrochloride Teva tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Do not store in a refrigerator or freezer.

The medication is taken orally as a tablet, usually with a full glass of water. Doses are generally spaced throughout the day, and the last dose should be taken at least four hours before bedtime to reduce the risk of supine hypertension.

The most serious risks include severe supine hypertension, which can lead to cardiovascular complications, and rare but serious cardiac events such as arrhythmias or myocardial ischemia. Patients should be monitored closely for any signs of excessive blood pressure elevation.

Midodrine is contraindicated in patients with severe organic heart disease, acute renal failure, urinary retention, pheochromocytoma, or known hypersensitivity to the drug. It should also be avoided in individuals who cannot safely monitor their blood pressure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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