Product image of Midodrine Teva (Midodrine Hydrochloride) supplied by GNH India

Midodrine Teva

Active Ingredient:
Midodrine Hydrochloride
Origin:
EU

Midodrine Teva (Midodrine Hydrochloride)

Midodrine, the active ingredient in Midodrine Teva, is a Alpha-1 adrenergic agonist presented as an oral tablet for oral use. It is used to treat orthostatic hypotension in adults by raising blood pressure when standing. The medication is formulated for systemic absorption and is prescribed when conventional measures such as fluid intake and compression stockings are insufficient.

GNH India supplies Midodrine Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics to support the needs of healthcare providers across multiple regions.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Midodrine acts on the vascular system to counteract low blood pressure associated with orthostatic disorders.

  • Orthostatic hypotension: increases standing blood pressure and reduces dizziness and fainting episodes.
  • Neurogenic orthostatic hypotension: improves autonomic regulation of vascular tone in patients with autonomic failure.
  • Post‑ural hypotension: helps maintain adequate cerebral perfusion after prolonged standing.

How It Works

  • Midodrine is a prodrug that is rapidly converted to its active metabolite, desglymidodrine, which selectively stimulates α1‑adrenergic receptors on peripheral vascular smooth muscle. Activation of these receptors induces vasoconstriction, raising systemic vascular resistance and thereby increasing arterial blood pressure, particularly in the upright position. The effect is dose‑dependent and primarily influences the venous capacitance vessels, helping to counteract the pooling of blood in the lower extremities.

Side Effects

Midodrine may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Piloerection (goosebumps)
  • Pruritus (itching)
  • Urinary retention
  • Supine hypertension
  • Headache

Serious or Rare Side Effects

  • Severe hypertension leading to chest pain or stroke
  • Bradycardia or cardiac arrhythmias
  • Anaphylactic or severe allergic reactions

Precautions & Warnings

Before prescribing Midodrine, clinicians should consider several precautionary measures to ensure patient safety.

  • Blood pressure monitoring: check supine and standing measurements before and during therapy.
  • Cardiovascular disease: avoid in patients with severe ischemic heart disease or uncontrolled hypertension.
  • Renal impairment: use caution and consider dose adjustment in severe renal dysfunction.
  • Pregnancy and lactation: safety has not been established; prescribe only if potential benefit outweighs risk.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Midodrine may interact with other medicines, requiring careful assessment before co‑administration.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): additive hypertensive effect.
  • Other α1‑adrenergic agonists (e.g., phenylephrine): risk of excessive vasoconstriction.
  • Direct vasopressors (e.g., norepinephrine): may cause severe hypertension.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate orthostatic hypotension when therapy is withdrawn.
  • Antihypertensive agents (ACE inhibitors, beta‑blockers): monitor for excessive blood pressure lowering.
  • Tricyclic antidepressants: possible increase in blood pressure.
  • SSRIs or SNRIs: may modestly affect blood pressure response.

Frequently Asked Questions

Midodrine Teva is indicated for the treatment of orthostatic hypotension, a condition where blood pressure falls significantly upon standing. By raising vascular tone, it helps reduce dizziness, light‑headedness, and fainting episodes associated with low standing blood pressure.

Midodrine is converted in the body to desglymidodrine, which selectively activates α1‑adrenergic receptors on peripheral blood vessels. This activation causes vasoconstriction, increasing systemic vascular resistance and elevating arterial pressure, especially when a patient moves to an upright position.

The prescribed dose of Midodrine is individualized by the treating clinician based on the patient’s blood‑pressure response and tolerance. Typical regimens start with a low dose taken several times daily, but the exact amount and schedule must be determined by a qualified healthcare professional.

Safety data for Midodrine in pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Midodrine differs from agents such as fludrocortisone by directly causing peripheral vasoconstriction rather than expanding plasma volume. It often provides a faster rise in standing blood pressure, whereas fludrocortisone works more gradually through sodium retention. Choice of therapy depends on patient profile, comorbidities and physician judgment.

Midodrine Teva tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct light, and ensure the container is tightly closed to maintain product stability throughout its shelf life.

Midodrine Teva is taken orally, usually with a full glass of water. Doses are generally spaced throughout the day, and the medication should be taken during waking hours to avoid supine hypertension. Patients should follow the prescribing clinician’s instructions regarding timing and food intake.

The most critical safety concerns include severe or supine hypertension, which can lead to chest pain, stroke, or organ damage, and rare cardiac arrhythmias such as bradycardia. Patients should report any sudden headache, visual changes, chest discomfort, or palpitations promptly to their healthcare provider.

Midodrine is contraindicated in patients with severe organic heart disease, uncontrolled hypertension, or known hypersensitivity to the drug or its excipients. It should also be avoided in individuals with urinary retention due to prostate enlargement unless closely monitored, and in anyone where the risk‑benefit assessment is unfavorable.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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