Product image of Midodrine Tillomed (Midodrine Hydrochloride) supplied by GNH India

Midodrine Tillomed

Active Ingredient:
Midodrine Hydrochloride
Origin:
EU

Midodrine Tillomed (Midodrine Hydrochloride)

Midodrine Hydrochloride, the active ingredient in Midodrine Tillomed, is an Alpha-1 adrenergic agonist presented as an oral tablet for systemic use. It is used to raise blood pressure in patients with orthostatic hypotension, particularly adults who experience symptomatic drops upon standing.
GNH India supplies Midodrine Tillomed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tillomed Pharma Gmbh

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Indications & Clinical Uses

Midodrine Tillomed acts on the peripheral vascular system to treat low‑blood‑pressure conditions.

  • Orthostatic hypotension: increases standing blood pressure and reduces dizziness or fainting episodes in affected patients.

How It Works

  • Midodrine is a pro‑drug that is rapidly converted to desglymidodrine, an active metabolite that stimulates peripheral alpha‑1 adrenergic receptors. Activation of these receptors causes vasoconstriction, raising systemic vascular resistance and consequently increasing arterial blood pressure without directly affecting heart rate.

Side Effects

Midodrine Tillomed may cause a range of adverse reactions.

Common Side Effects

  • Piloerection: localized goose‑flesh skin reaction.
  • Pruritus: mild itching, often on the torso.
  • Urinary retention: difficulty emptying the bladder.
  • Supine hypertension: elevated blood pressure while lying down.

Serious or Rare Side Effects

  • Severe hypertension: rapid, dangerous rise in blood pressure.
  • Bradycardia: unusually slow heart rate.
  • Allergic reaction: rash, swelling, or difficulty breathing.

Precautions & Warnings

Before prescribing Midodrine Tillomed, clinicians should consider several safety measures.

  • Blood pressure monitoring: check supine and standing readings regularly.
  • Supine positioning: advise patients to avoid lying flat for prolonged periods.
  • Cardiovascular disease: use caution in patients with known heart conditions.
  • Renal impairment: dose adjustment may be needed in reduced kidney function.
  • Concomitant antihypertensives: assess risk of excessive blood pressure elevation.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Midodrine Tillomed can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other antihypertensive agents: additive blood‑pressure lowering effect.
  • Clonidine: may blunt the pressor response.

Moderate Interactions (Monitor Closely)

  • Diuretics: may amplify orthostatic changes.
  • Tricyclic antidepressants: potential for increased blood pressure.
  • Selective serotonin reuptake inhibitors (SSRIs): monitor for hypertension.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may affect renal handling of fluid.

Frequently Asked Questions

Midodrine Tillomed is prescribed to treat orthostatic hypotension, a condition where blood pressure falls significantly upon standing, causing dizziness, light‑headedness, or fainting. By increasing vascular tone, the medication helps maintain adequate blood pressure when patients change posture.

Midodrine Hydrochloride is a pro‑drug that is converted in the body to desglymidodrine. The active metabolite binds to peripheral alpha‑1 adrenergic receptors, causing vasoconstriction of blood vessels, which raises systemic vascular resistance and elevates arterial blood pressure.

The dosage of Midodrine Tillomed is individualized by the prescribing clinician based on the patient’s blood‑pressure response, severity of symptoms, and overall health status. The prescriber determines the appropriate amount, timing, and titration schedule.

Safety data for Midodrine Hydrochloride in pregnancy and lactation are limited, and the product’s pregnancy category is listed as unknown. Healthcare providers should weigh potential benefits against possible risks before prescribing to pregnant or nursing individuals.

To request Midodrine Tillomed, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Midodrine is unique as an oral alpha‑1 adrenergic agonist that directly increases vascular tone. Other antihypotensive options, such as fludrocortisone, act by expanding plasma volume. Choice of therapy depends on patient profile, comorbidities, and tolerance to side‑effects.

Midodrine Tillomed should be stored at room temperature, below 25 °C. Keep the tablets in their original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Midodrine Tillomed is taken orally, usually with a full glass of water. It is commonly prescribed to be taken during the day, avoiding doses close to bedtime to reduce the risk of supine hypertension.

The most serious risks include severe hypertension, especially when lying down, and rare cases of bradycardia or allergic reactions. Patients should be educated to monitor blood pressure regularly and seek immediate medical attention if they experience chest pain, severe headache, or signs of an allergic response.

Midodrine is contraindicated in patients with known hypersensitivity to the drug, severe organic heart disease, uncontrolled hypertension, or those taking monoamine oxidase inhibitors. It should also be used with caution in individuals with renal impairment or a history of urinary retention.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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