Product image of Midodrine Tillomed Laboratories (Midodrine Hydrochloride) supplied by GNH India

Midodrine Tillomed Laboratories

Active Ingredient:
Midodrine Hydrochloride
Origin:
EU

Midodrine Tillomed Laboratories (Midodrine Hydrochloride)

Midodrine, the active ingredient in Midodrine Tillomed Laboratories, is an Alpha-1 adrenergic agonist presented as a tablet for oral use. It is used to raise blood pressure in patients with orthostatic hypotension and related conditions.

GNH India supplies Midodrine Tillomed Laboratories as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Tillomed Laboratories Ltd

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Indications & Clinical Uses

Midodrine acts on the peripheral vascular system to treat low‑blood‑pressure disorders.

  • Orthostatic hypotension: increases standing systolic pressure and reduces dizziness or fainting.
  • Neurogenic hypotension: improves vascular tone in autonomic failure.
  • Chronic hypotension: supports overall blood‑pressure stability in patients with persistent low readings.

How It Works

  • Midodrine is a pro‑drug that is rapidly converted to desglymidodrine, an active metabolite that selectively stimulates peripheral alpha‑1 adrenergic receptors. Activation of these receptors causes arteriolar and venous vasoconstriction, leading to an increase in systemic vascular resistance and a rise in arterial blood pressure.

Side Effects

Midodrine may cause a range of adverse reactions, most of which are dose‑related.

Common Side Effects

  • Piloerection (goose‑flesh skin)
  • Pruritus (itching)
  • Urinary retention
  • Supine hypertension
  • Headache
  • Paresthesia (tingling)

Serious or Rare Side Effects

  • Severe hypertension (especially when lying down)
  • Myocardial infarction
  • Pulmonary edema
  • Bradycardia
  • Anaphylactic reactions
  • Skin necrosis at injection sites (if applicable)

Precautions & Warnings

Before prescribing Midodrine, clinicians should consider several safety measures.

  • Monitor blood pressure: check supine and standing readings regularly.
  • Avoid use in severe cardiac disease: risk of excessive vasoconstriction.
  • Caution in renal impairment: adjust monitoring as clearance may be affected.
  • Do not combine with other vasopressors without supervision.
  • Pregnancy: safety unknown; weigh benefits against potential risks.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Midodrine can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other alpha‑agonists: additive pressor effect may cause severe hypertension.
  • Tricyclic antidepressants: can amplify blood‑pressure response.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypotensive effect when discontinued.
  • Beta‑blockers: may mask compensatory tachycardia.
  • Anticholinergics: may worsen urinary retention.
  • Calcium channel blockers: possible additive vascular effects.

Frequently Asked Questions

Midodrine Tillomed Laboratories contains midodrine hydrochloride and is prescribed to treat orthostatic hypotension, a condition where blood pressure falls upon standing, causing dizziness or fainting. It helps raise standing blood pressure by constricting peripheral blood vessels.

Midodrine is a pro‑drug that is converted to desglymidodrine, which selectively activates peripheral alpha‑1 adrenergic receptors. This activation causes vasoconstriction of arterioles and veins, increasing systemic vascular resistance and thereby raising arterial blood pressure.

The dosage of Midodrine Tillomed Laboratories is determined by the prescribing clinician based on the patient’s blood‑pressure response, severity of symptoms, and overall health status. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of midodrine in pregnancy and lactation has not been established. Healthcare providers should consider the potential benefits against unknown risks and discuss alternative options when treating pregnant or nursing individuals.

To request Midodrine Tillomed Laboratories, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Midodrine is an oral alpha‑1 adrenergic agonist, whereas alternatives such as fludrocortisone act by increasing plasma volume. Midodrine provides a rapid pressor effect without fluid retention, but it may cause supine hypertension, a risk less common with volume‑expanding agents.

Midodrine Tillomed Laboratories should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Maintaining these conditions helps preserve tablet integrity and potency.

Midodrine Tillomed Laboratories is taken orally, usually with a full glass of water. It is commonly prescribed to be taken during the day, avoiding doses close to bedtime to reduce the risk of supine hypertension.

The most serious risks include severe or supine hypertension, which can lead to cardiovascular events such as myocardial infarction or stroke, and rare cases of anaphylaxis. Patients should be monitored for signs of excessive blood‑pressure elevation, especially when lying down.

Midodrine is contraindicated in patients with severe organic heart disease, acute renal failure, or known hypersensitivity to the drug. It should also be avoided in individuals with uncontrolled hypertension or those taking certain interacting medications without close supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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