Product image of Mifegyne (Mifepristone) supplied by GNH India

Mifegyne

Active Ingredient:
Mifepristone
Origin:
EU

Mifegyne (Mifepristone)

Mifepristone, the active ingredient in Mifegyne, is a progesterone receptor antagonist presented as a tablet for oral use. It is employed to medically terminate early intrauterine pregnancy under clinical supervision. The drug works by blocking progesterone, a hormone essential for maintaining the uterine lining, thereby facilitating embryo detachment and uterine expulsion.

GNH India supplies Mifegyne as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across multiple regions.

Manufacturer / TM Owner

Exelgyn Sa

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Indications & Clinical Uses

  • Mifegyne (mifepristone) is used in the medical management of early intrauterine pregnancy termination.
  • Early intrauterine pregnancy termination: induces abortion in pregnancies up to 10 weeks gestation by disrupting progesterone support.
  • Combination regimen with misoprostol: enhances uterine expulsion when used sequentially after mifepristone.

How It Works

  • Mifepristone binds competitively to progesterone receptors in the uterus, preventing progesterone from maintaining the decidua. This antagonism leads to decidual breakdown and detachment of the embryo. The altered uterine environment also sensitizes myometrial tissue to prostaglandins, facilitating uterine contractions and expulsion of pregnancy tissue.

Side Effects

Mifegyne may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea or vomiting
  • Abdominal or pelvic pain
  • Vaginal bleeding or spotting
  • Fatigue or headache
  • Diarrhea or constipation
  • Dizziness or mild fever

Serious or Rare Side Effects

  • Severe hemorrhage requiring medical intervention
  • Infection or sepsis following incomplete abortion
  • Allergic reaction including rash, swelling, or anaphylaxis
  • Liver injury or elevated hepatic enzymes
  • Uterine rupture (very rare)

Precautions & Warnings

  • Prior to prescribing Mifegyne, clinicians should observe several safety considerations.
  • Confirm gestational age: ensure pregnancy is ≤10 weeks.
  • Screen for ectopic pregnancy: rule out non‑intrauterine gestation.
  • Assess contraindications: avoid in chronic adrenal insufficiency, anticoagulant therapy, or severe anemia.
  • Monitor vital signs: observe for excessive bleeding or infection after administration.
  • Store at ambient temperature: keep below 25 °C in original packaging, protected from moisture.

Avoid Interactions

Mifegyne can interact with other medicines that affect its metabolism or hemostasis.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly reduce efficacy.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase drug exposure and risk of toxicity.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin): may heighten bleeding risk.
  • Corticosteroids: may mask adrenal insufficiency symptoms.
  • Hormonal contraceptives: may have reduced effectiveness when used concurrently.
  • Antifungal azoles (e.g., fluconazole): may modestly increase serum levels.

Frequently Asked Questions

Mifegyne is used to medically terminate an early intrauterine pregnancy. It is part of a regimen that induces abortion in pregnancies up to approximately 10 weeks, providing a non‑surgical option under clinical supervision.

Mifepristone blocks progesterone receptors in the uterus, preventing the hormone from supporting the pregnancy. This causes the uterine lining to break down and the embryo to detach, while also making the uterus more responsive to prostaglandins that promote expulsion.

The exact dose of Mifegyne is determined by the prescribing clinician. Typically, a single oral tablet is given, followed by misoprostol after a specified interval, but the regimen is individualized based on clinical guidelines and patient factors.

Mifegyne is contraindicated in ongoing pregnancy beyond the approved gestational limit and should not be used to treat conditions unrelated to early pregnancy termination. Breastfeeding is not recommended during treatment because the drug may pass into milk and affect the infant.

To order Mifegyne, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to Mifegyne is a surgical abortion or the use of misoprostol alone. Mifegyne combined with misoprostol offers a high efficacy rate for early medical abortion, while avoiding surgical intervention and allowing outpatient management.

Mifegyne tablets should be stored at ambient temperature, below 25 °C, in their original packaging to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Mifegyne is taken orally as a single tablet under medical supervision. After a prescribed interval, usually 24–48 hours, a second medication such as misoprostol is administered to complete the abortion process.

Serious risks include heavy or uncontrolled bleeding, infection or sepsis, severe allergic reactions, and, rarely, uterine rupture. Patients should be instructed to seek immediate medical attention if they experience intense abdominal pain, excessive bleeding, fever, or signs of an allergic reaction.

Mifegyne should not be used in individuals with chronic adrenal insufficiency, uncontrolled severe anemia, anticoagulant therapy, known hypersensitivity to mifepristone, ectopic pregnancy, or when the gestational age exceeds the approved limit for medical abortion.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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