Product image of Miflasone (Beclometasone Dipropionate) supplied by GNH India

Miflasone

Active Ingredient:
Beclometasone Dipropionate
Origin:
EU

Miflasone (Beclometasone Dipropionate)

Beclometasone dipropionate, the active ingredient in Miflasone, is a corticosteroid presented as an inhalation formulation for inhalation use. It treats asthma and chronic obstructive pulmonary disease (COPD) in adults and children by reducing airway inflammation and hyper‑responsiveness. It is indicated for maintenance therapy and can be used as part of a step‑wise treatment plan.

GNH India supplies Miflasone as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance, regulatory compliance and reliable logistics.

Manufacturer / TM Owner

Novartis Pharma S.A.S.

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Indications & Clinical Uses

  • Miflasone, a corticosteroid inhaler, acts on airway inflammation in respiratory disease.
  • Asthma: reduces airway inflammation, improves lung function and decreases frequency of symptoms.
  • COPD: decreases exacerbations, improves airflow and helps control chronic symptoms.
  • Exercise‑induced bronchoconstriction: provides prophylactic anti‑inflammatory control to prevent airway narrowing during physical activity.

How It Works

  • Beclometasone dipropionate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This action suppresses the production of pro‑inflammatory cytokines, chemokines and adhesion molecules, leading to reduced recruitment of inflammatory cells in the airway mucosa and decreased airway hyper‑responsiveness. The overall effect is a rapid decrease in airway edema and mucus secretion, contributing to improved airflow.

Side Effects

Beclometasone dipropionate may cause local and systemic adverse reactions, which are categorized by frequency.

Common Side Effects

  • Oral thrush (candidiasis): fungal infection of the mouth.
  • Hoarseness or dysphonia: voice changes due to laryngeal irritation.
  • Cough or throat irritation: mild respiratory discomfort.
  • Headache: mild to moderate pain.

Serious or Rare Side Effects

  • Adrenal suppression: reduced cortisol production with systemic exposure.
  • Pneumonia: increased risk of lower respiratory tract infection.
  • Paradoxical bronchospasm: sudden worsening of airway obstruction after inhalation.

Precautions & Warnings

When prescribing Miflasone, clinicians should observe the following precautions to ensure safe use.

  • Assess infection risk: avoid use during active respiratory infections.
  • Monitor growth in children: long‑term therapy may affect growth velocity.
  • Ensure proper inhalation technique: use spacer and rinse mouth to reduce local effects.
  • Avoid abrupt discontinuation: taper dosage if used for extended periods.
  • Review concomitant steroids: cumulative systemic exposure may increase side‑effects.
  • Store at room temperature: keep device in original packaging, protect from moisture and heat.

Avoid Interactions

Beclometasone dipropionate can interact with other medicines; notable interactions are grouped by clinical significance.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase systemic corticosteroid levels.
  • Live vaccines: risk of systemic immunosuppression and reduced vaccine efficacy.
  • Concurrent use of multiple inhaled corticosteroids: risk of overdose and systemic effects.

Moderate Interactions (Monitor Closely)

  • Systemic corticosteroids: additive immunosuppressive effects.
  • β2‑agonists: may mask worsening asthma symptoms.
  • Diuretics: potential for hypokalemia when combined with systemic exposure.

Frequently Asked Questions

Miflasone is an inhaled corticosteroid indicated for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD). It helps control airway inflammation, reduces symptom frequency, and lowers the risk of exacerbations when used as part of a regular treatment regimen.

Beclometasone dipropionate binds to glucocorticoid receptors inside airway cells, altering gene transcription to suppress pro‑inflammatory cytokines and chemokines. This reduces inflammatory cell recruitment, edema, and mucus production, leading to decreased airway hyper‑responsiveness and improved airflow.

The appropriate dose of Miflasone is determined by the prescribing healthcare professional based on the severity of the patient’s asthma or COPD, age, response to therapy, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The pregnancy safety category for beclometasone dipropionate is not definitively established. Use during pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks and alternatives with their doctor.

To order Miflasone, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Miflasone contains beclometasone dipropionate, a well‑studied corticosteroid with a high topical potency and low systemic bioavailability when inhaled. Compared with agents such as budesonide or fluticasone, it offers similar anti‑inflammatory efficacy, but differences in particle size, device compatibility and dosing frequency may influence individual patient preference and adherence.

Miflasone should be stored at room temperature, below 25 °C, in its original packaging. Keep the inhaler away from direct sunlight, moisture and heat sources. Do not expose the device to freezing temperatures, and ensure the mouthpiece is clean before each use.

Miflasone is administered by inhalation using the supplied inhaler device. The patient should exhale fully, place the mouthpiece in the mouth, inhale steadily and deeply while actuating the device, then hold the breath for several seconds before exhaling. Rinsing the mouth after use helps reduce local side effects.

Serious risks include adrenal suppression, which can lead to reduced cortisol production, and paradoxical bronchospasm, a sudden worsening of airway obstruction after inhalation. Patients should also be alert for signs of pneumonia or severe allergic reactions and seek medical attention promptly if these occur.

Miflasone should be avoided in individuals with known hypersensitivity to beclometasone dipropionate or any component of the inhaler. It is also contraindicated in patients with active, untreated respiratory infections that could be worsened by corticosteroid therapy, unless the prescriber decides the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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