Mig-400 (Ibuprofen)

Ibuprofen acts on inflammatory pathways to relieve pain, reduce fever, and decrease swelling.

• Mild to moderate pain: provides analgesic relief for headaches, dental pain, musculoskeletal discomfort, and other common aches.
• Fever: lowers elevated body temperature by acting on the hypothalamic heat-regulating center.
• Inflammatory conditions such as arthritis: diminishes joint inflammation and associated stiffness.

• Ibuprofen reversibly inhibits cyclooxygenase enzymes COX‑1 and COX‑2, reducing the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels decrease inflammation, pain signaling, and fever generation, producing its therapeutic effects.

Adverse reactions may range from mild to severe, depending on individual susceptibility and exposure.

Common Side Effects

• Gastrointestinal upset (nausea, dyspepsia)
• Headache
• Dizziness
• Mild rash or itching
• Elevated blood pressure
• Tinnitus (ringing in ears)

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration
• Severe allergic reactions (anaphylaxis, angioedema)
• Acute renal failure or significant decline in kidney function
• Hepatotoxicity (liver injury)
• Cardiovascular events such as myocardial infarction or stroke
• Blood dyscrasias (e.g., thrombocytopenia, leukopenia).

Before using Mig-400, consider the following safety measures.

• Assess renal function: use with caution in patients with existing kidney disease.
• Evaluate gastrointestinal risk: avoid in individuals with active ulcers or a history of serious GI bleeding.
• Review cardiovascular status: consider increased risk of thrombotic events in patients with heart disease.
• Check for hypersensitivity: do not use if allergic to ibuprofen or other NSAIDs.
• Use during pregnancy and lactation only under medical advice.
• Store at ambient temperature: keep in the original container, protect from moisture and heat.

Ibuprofen can affect the activity of several other medicines.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): heightened risk of bleeding.
• Selective serotonin reuptake inhibitors (SSRIs): increased gastrointestinal bleeding potential.
• Lithium: ibuprofen may raise lithium serum concentrations.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in renal function.
• Diuretics: may exacerbate renal perfusion deficits.
• Methotrexate: decreased clearance leading to toxicity.
• Corticosteroids: additive risk of gastrointestinal ulceration.