Product image of Migraeflux Mcp (Paracetamol, Metoclopramide Hydrochloride Monohydrate) supplied by GNH India

Migraeflux Mcp

Active Ingredient:
Paracetamol, Metoclopramide Hydrochloride Monohydrate
Origin:
EU

Migraeflux Mcp (Paracetamol, Metoclopramide Hydrochloride Monohydrate)

Paracetamol, the active ingredient in Migraeflux Mcp, is an analgesic presented as a tablet for oral use. It is combined with Metoclopramide Hydrochloride Monohydrate, an antiemetic, to treat migraine headache and acute headache accompanied by nausea or vomiting in adults.

GNH India supplies Migraeflux Mcp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Hennig Arzneimittel Gmbh & Co. Kg

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Indications & Clinical Uses

Migraeflux Mcp is indicated for migraine and related headache disorders where pain is accompanied by gastrointestinal symptoms. It provides both analgesic and anti‑emetic effects.

  • Migraine headache: reduces pain intensity and associated nausea.
  • Acute headache with nausea/vomiting: offers rapid pain relief and controls vomiting.
  • Tension‑type headache with nausea: alleviates discomfort when nausea is present.

How It Works

  • Paracetamol exerts central analgesic and antipyretic actions, likely through COX enzyme inhibition and modulation of serotonergic pathways. Metoclopramide Hydrochloride Monohydrate blocks dopamine D2 receptors, enhancing gastrointestinal motility and providing anti‑emetic effects by acting on the chemoreceptor trigger zone.

Side Effects

Adverse reactions may occur with Migraeflux Mcp and should be monitored.

Common Side Effects

  • Drowsiness: mild sedation or fatigue.
  • Dry mouth: reduced salivation.
  • Constipation: slowed bowel movements.
  • Dizziness: light‑headed sensation.
  • Nausea: occasional upset stomach.
  • Headache: paradoxical worsening.

Serious or Rare Side Effects

  • Extrapyramidal symptoms: muscle rigidity or tremor.
  • Allergic reactions: rash, itching, or swelling.
  • Severe skin reactions: Stevens‑Johnson syndrome.
  • Neutropenia: low white‑blood cell count.
  • Hepatotoxicity: liver enzyme elevation.
  • Anaphylaxis: rapid, life‑threatening allergic response.

Precautions & Warnings

Before prescribing Migraeflux Mcp, consider patient‑specific factors and monitor for adverse events.

  • Liver function: assess in patients with hepatic disease.
  • Movement disorders: watch for extrapyramidal signs, especially in the elderly.
  • Hypersensitivity: avoid in individuals with known allergy to paracetamol or metoclopramide.
  • Drug interactions: review concomitant medications that affect dopamine pathways.
  • Pregnancy and lactation: use only if benefits outweigh potential risks.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Migraeflux Mcp may interact with several medicines; clinicians should evaluate the risk.

Major Interactions (Avoid)

  • MAO inhibitors: increased risk of hypertensive crisis.
  • Antipsychotics (e.g., haloperidol): heightened extrapyramidal effects.
  • Warfarin: potentiation of anticoagulant effect, monitor INR.

Moderate Interactions (Monitor Closely)

  • CYP450 inducers (e.g., rifampicin): may reduce paracetamol efficacy.
  • SSRIs or SNRIs: potential for serotonin syndrome.
  • Alcohol: increased hepatotoxic risk.
  • Other analgesics: additive central nervous system depression.

Frequently Asked Questions

Migraeflux Mcp is a combination oral medication containing paracetamol and metoclopramide hydrochloride monohydrate. It is used to treat migraine headaches and other acute headaches that are accompanied by nausea or vomiting, providing both pain relief and anti‑emetic action.

Paracetamol acts centrally by inhibiting cyclooxygenase enzymes and modulating serotonergic pathways, which reduces the perception of pain and lowers fever. In Migraeflux Mcp, it provides the primary analgesic effect for headache relief.

The specific dose and dosing schedule of Migraeflux Mcp are determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and clinical response. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of Migraeflux Mcp in pregnancy or while breastfeeding has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Migraeflux Mcp, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Migraeflux Mcp combines an analgesic (paracetamol) with an anti‑emetic (metoclopramide), offering simultaneous pain relief and control of nausea. Unlike triptans, which target serotonin receptors, this combination is generally well‑tolerated and can be used when triptans are contraindicated or ineffective.

Migraeflux Mcp should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Migraeflux Mcp is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed, unless otherwise directed by a healthcare professional.

Serious risks include extrapyramidal symptoms such as muscle rigidity or tremor, severe allergic reactions including anaphylaxis, and rare skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience any of these symptoms.

Migraeflux Mcp should be avoided in individuals with known hypersensitivity to paracetamol, metoclopramide, or any of the excipients, as well as in patients with severe liver disease, uncontrolled epilepsy, or those taking monoamine oxidase inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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