Product image of Migrafen (Ibuprofen Bp) supplied by GNH India

Migrafen

Active Ingredient:
Ibuprofen Bp
Origin:
EU

Migrafen (Ibuprofen Bp)

Ibuprofen, the active ingredient in Migrafen, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It is employed to relieve mild to moderate pain, reduce fever, and lessen inflammation in adults and children when appropriate.

GNH India supplies Migrafen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand. Customers benefit from reliable logistics, documentation support, and consistent product availability across regions.

Manufacturer / TM Owner

Chelonia Healthcare Limited

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Indications & Clinical Uses

Ibuprofen, an NSAID, acts on inflammatory pathways to provide analgesic, antipyretic and anti‑inflammatory effects.

  • Mild to moderate pain: Reduces pain intensity by decreasing prostaglandin‑mediated sensitization of nociceptors.
  • Fever: Lowers elevated body temperature through inhibition of prostaglandin synthesis in the hypothalamus.
  • Inflammation: Diminishes swelling and redness by limiting inflammatory mediator production.

How It Works

  • Ibuprofen reversibly inhibits cyclo‑oxygenase enzymes COX‑1 and COX‑2, which catalyze the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it decreases peripheral sensitization of pain receptors, lowers the hypothalamic set‑point for temperature, and limits the vascular and cellular components of inflammation. The reversible nature of inhibition allows normal prostaglandin production to resume after the drug is cleared.

Side Effects

Ibuprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash or mild itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Renal impairment or acute kidney injury.
  • Severe hypersensitivity reactions such as Stevens‑Johnson syndrome.
  • Hepatotoxicity or elevated liver enzymes.

Precautions & Warnings

When using ibuprofen, several safety considerations should be observed.

  • Assess renal function: avoid use in patients with severe kidney disease or dehydration.
  • Monitor gastrointestinal risk: use with caution in individuals with a history of ulcers or bleeding.
  • Evaluate cardiovascular status: limit use in patients with uncontrolled hypertension or heart failure.
  • Review concomitant medications: avoid concurrent use with other NSAIDs or anticoagulants without medical guidance.
  • Pregnancy and lactation: consult a healthcare professional before use during pregnancy or breastfeeding.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Ibuprofen can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Lithium: ibuprofen may raise lithium serum concentrations, risking toxicity.
  • Methotrexate: reduced renal clearance can lead to toxic levels.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may diminish antihypertensive effect and affect kidney function.
  • Diuretics: combined use can increase risk of renal impairment.
  • Selective serotonin reuptake inhibitors (SSRIs): may modestly raise bleeding risk.

Frequently Asked Questions

Migrafen contains ibuprofen, an NSAID that is commonly prescribed to relieve mild to moderate pain, reduce fever, and treat inflammation caused by conditions such as musculoskeletal injuries, dental procedures, or viral infections. It works across a broad patient population, including adults and, when appropriate, children, under the guidance of a healthcare professional.

Ibuprofen works by reversibly blocking the cyclo‑oxygenase enzymes COX‑1 and COX‑2, which are essential for converting arachidonic acid into prostaglandins. Prostaglandins mediate pain, fever, and inflammation, so their reduction leads to decreased sensation of pain, lower body temperature, and diminished swelling at the site of inflammation.

The appropriate dose of Migrafen is determined by the prescribing clinician based on the individual’s age, weight, medical condition, and response to therapy. Healthcare providers select the strength, frequency, and duration that best address the patient’s specific needs while minimizing potential risks.

Safety of ibuprofen during pregnancy and lactation depends on the trimester and clinical circumstances. Generally, ibuprofen is avoided in the third trimester because it may affect fetal cardiovascular function. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives and risks with their healthcare provider before using Migrafen.

To request Migrafen, visit the product page on gnhindia.com and submit an enquiry with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifying trade or institutional credentials before providing a quotation, confirming availability, arranging shipping (including any required temperature control), and handling import documentation.

Migrafen (ibuprofen) shares the core anti‑inflammatory, analgesic, and antipyretic properties of the NSAID class. Compared with some NSAIDs such as naproxen, ibuprofen has a shorter half‑life, which may allow more flexible dosing but may also require more frequent administration. Its safety profile is well‑characterized, though gastrointestinal and renal considerations are similar across the class.

Migrafen should be stored at ambient temperature, ideally below 25 °C, in its original container to protect it from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments. No special refrigeration is required for this oral formulation.

Migrafen is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal discomfort. The tablet should be swallowed whole and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious adverse events associated with ibuprofen include gastrointestinal bleeding or ulceration, severe renal impairment, and rare hypersensitivity reactions such as Stevens‑Johnson syndrome or anaphylaxis. Patients should seek immediate medical attention if they notice black stools, unexplained bruising, sudden swelling, rash, or difficulty breathing while using Migrafen.

Migrafen should be avoided in individuals with known hypersensitivity to ibuprofen or other NSAIDs, those with active gastrointestinal ulcers, severe heart failure, or uncontrolled hypertension. It is also contraindicated in patients receiving certain anticoagulants, lithium, or high‑dose methotrexate without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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