Product image of Migraleve Yellow (Paracetamol, Codeine Phosphate) supplied by GNH India

Migraleve Yellow

Active Ingredient:
Paracetamol, Codeine Phosphate
Origin:
EU

Migraleve Yellow (Paracetamol, Codeine Phosphate)

Paracetamol, the active ingredient in Migraleve Yellow, is an analgesic presented as an oral tablet for systemic use. Together with codeine phosphate, it provides pain relief for migraine and other headache disorders in adult patients, helping to reduce the intensity and duration of acute attacks. It is formulated for rapid absorption to address sudden pain episodes.

GNH India supplies Migraleve Yellow as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality compliance with EU standards and reliable logistics for global distribution.

Manufacturer / TM Owner

Jntl Consumer Health I (Ireland) Limited

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Migraleve Yellow, containing paracetamol and codeine phosphate, is indicated for conditions involving acute headache and migraine pain.

  • Migraine: provides relief of moderate to severe migraine attacks, reducing pain and associated symptoms.
  • Tension‑type headache: alleviates pain intensity, helping patients resume normal activities.
  • Other acute headache: offers effective analgesia when alternative treatments are insufficient.

How It Works

  • Paracetamol acts centrally by inhibiting the synthesis of prostaglandins in the brain, which lowers the pain threshold and reduces fever. Codeine phosphate is a μ‑opioid receptor agonist that binds to receptors in the central nervous system, producing analgesic and antitussive effects through modulation of pain signaling pathways. This dual action addresses both peripheral and central components of headache pain.

Side Effects

Paracetamol and codeine phosphate may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea
  • Constipation
  • Drowsiness or sedation
  • Dizziness

Serious or Rare Side Effects

  • Respiratory depression, especially at higher doses or in sensitive individuals
  • Severe allergic reactions such as anaphylaxis or skin rash
  • Liver toxicity from paracetamol overdose
  • Dependence or withdrawal symptoms with prolonged codeine use

Precautions & Warnings

When using Migraleve Yellow, several precautions should be observed to minimize risk.

  • Pregnancy: consult a healthcare professional before use, as safety data are limited.
  • Alcohol consumption: avoid excessive alcohol, which can increase liver toxicity.
  • Liver disease: use with caution and consider dose adjustment in patients with hepatic impairment.
  • Kidney disease: monitor renal function, especially in patients with chronic kidney disease.
  • Opioid dependence: assess risk of dependence before prescribing codeine-containing products.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Migraleve Yellow can interact with other medicines; awareness of major and moderate interactions helps ensure safe use.

Major Interactions (Avoid)

  • Other opioid analgesics: combined use may cause severe respiratory depression.
  • Alcohol or CNS depressants: increased sedation and respiratory risk.
  • MAO inhibitors: may enhance serotonergic effects leading to serotonin syndrome.
  • Additional paracetamol‑containing products: risk of cumulative hepatotoxicity.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs/SNRIs): possible increased risk of serotonin syndrome.
  • Antihistamines: may augment drowsiness and impair coordination.

Frequently Asked Questions

Migraleve Yellow is an over‑the‑counter oral tablet that combines paracetamol and codeine phosphate to treat moderate to severe migraine attacks, tension‑type headaches, and other acute headache episodes. It provides rapid analgesic relief, helping patients reduce pain intensity and resume normal activities.

Paracetamol works by inhibiting the central synthesis of prostaglandins, which are mediators that increase pain perception and fever. By reducing prostaglandin levels in the brain, it raises the pain threshold and contributes to the overall analgesic effect when combined with codeine.

The specific dose of Migraleve Yellow is determined by the prescribing healthcare professional based on the individual’s age, medical condition, and response to therapy. Patients should follow the prescriber’s instructions and not exceed the recommended amount indicated on the product label.

Safety data for the combination of paracetamol and codeine during pregnancy or lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using Migraleve Yellow to weigh potential benefits against possible risks.

To order Migraleve Yellow, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Migraleve Yellow combines a non‑opioid analgesic (paracetamol) with a weak opioid (codeine), offering a balance of pain relief and fewer gastrointestinal side effects compared with non‑steroidal anti‑inflammatory drugs (NSAIDs) such as ibuprofen. However, it carries opioid‑related risks, so clinicians consider patient history when choosing between options.

Store Migraleve Yellow at ambient temperature, preferably below 25 °C, in its original packaging. Keep the tablets away from moisture, direct sunlight and heat sources. Ensure the container is tightly closed to maintain product stability throughout its shelf life.

Migraleve Yellow is taken orally with a full glass of water. The tablet should be swallowed whole and not chewed or crushed. It is intended for adult use; children should not use this product unless specifically directed by a qualified healthcare professional.

The most serious risks include respiratory depression, especially when combined with other central nervous system depressants, severe allergic reactions such as anaphylaxis, liver injury from excessive paracetamol intake, and the potential for dependence or withdrawal symptoms related to the codeine component.

Migraleve Yellow should be avoided by individuals with known hypersensitivity to paracetamol, codeine, or any excipients in the tablet. It is also contraindicated in patients with severe respiratory depression, acute asthma attacks, or those taking monoamine oxidase inhibitors. Consultation with a healthcare professional is essential before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.