Product image of Migralgin (Paracetamol, Acetylsalicylic Acid, Caffeine) supplied by GNH India

Migralgin

Active Ingredient:
Paracetamol, Acetylsalicylic Acid, Caffeine
Origin:
EU

Migralgin (Paracetamol, Acetylsalicylic Acid, Caffeine)

Paracetamol, Acetylsalicylic Acid and Caffeine, the active ingredients in Migralgin, are an analgesic combination presented as an oral tablet for over‑the‑counter use. It treats headache, migraine, general pain and fever in adults and adolescents.

GNH India supplies Migralgin as a licensed, GDP‑compliant international pharmaceutical supplier serving pharmacies and clinics worldwide.

Manufacturer / TM Owner

Opella Healthcare Czech S.R.O

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Indications & Clinical Uses

  • Migralgin, a combination analgesic, works on pain and fever pathways.
  • Headache: provides rapid relief of mild to moderate headache pain.
  • Migraine: helps reduce the intensity of migraine attacks.
  • General pain: alleviates musculoskeletal, dental or other acute pain.
  • Fever: lowers elevated body temperature in febrile conditions.

How It Works

  • Paracetamol acts centrally to inhibit cyclo‑oxygenase enzymes and reduce prostaglandin synthesis, while acetylsalicylic acid irreversibly blocks COX‑1 and COX‑2, decreasing peripheral prostaglandin production. Caffeine antagonises adenosine receptors, producing mild central stimulation and enhancing the analgesic effect of the other two components, resulting in synergistic pain and fever relief.

Side Effects

Migralgin may cause a range of adverse reactions. Most are mild and reversible.

Common Side Effects

  • Nausea
  • Stomach discomfort or heartburn
  • Dizziness
  • Insomnia

Serious or Rare Side Effects

  • Allergic skin reactions such as rash or angioedema
  • Gastrointestinal bleeding or ulceration
  • Severe liver injury (rare)

Precautions & Warnings

Before using Migralgin, consider the following safety measures.

  • Aspirin allergy: avoid if you have a known hypersensitivity to acetylsalicylic acid.
  • Liver disease: use with caution in patients with hepatic impairment.
  • Alcohol consumption: limit intake as it may increase liver toxicity.
  • Hypertension: monitor blood pressure because caffeine can raise it.
  • Do not exceed recommended frequency: follow prescriber or label instructions.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Migralgin can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Warfarin or other oral anticoagulants: increased risk of bleeding.
  • Other NSAIDs or aspirin‑containing products: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: caffeine may reduce their blood‑pressure‑lowering effect.
  • Diuretics: caffeine can enhance diuretic action and electrolyte loss.
  • Methotrexate: aspirin may increase methotrexate toxicity.

Frequently Asked Questions

Migralgin is an over‑the‑counter combination analgesic used to relieve mild to moderate headache, migraine attacks, various types of acute pain such as dental or musculoskeletal pain, and to reduce fever in adults and adolescents.

Paracetamol reduces central prostaglandin synthesis, acetylsalicylic acid irreversibly blocks COX‑1 and COX‑2 enzymes decreasing peripheral prostaglandin production, and caffeine blocks adenosine receptors, providing mild stimulation and enhancing the analgesic effect of the other two agents, resulting in faster and stronger pain and fever relief.

The appropriate dose of Migralgin is determined by the prescribing healthcare professional based on the individual’s age, weight, medical condition and other medications. Patients should follow the dosage instructions on the product label or those provided by their prescriber.

Safety of Migralgin in pregnancy or while breastfeeding has not been fully established. Women who are pregnant, planning to become pregnant, or nursing should consult their healthcare provider before using this product to weigh potential benefits against possible risks.

To order Migralgin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and assistance with import documentation.

Compared with single‑ingredient products such as paracetamol alone, Migralgin adds acetylsalicylic acid for anti‑inflammatory effect and caffeine to boost analgesia, often providing faster and more complete relief for headache or migraine. However, the combination may carry higher risk of gastrointestinal irritation and bleeding than paracetamol alone.

Migralgin tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Migralgin is taken orally with a glass of water. It can be taken with or without food, but if gastrointestinal upset occurs, it may be helpful to take the tablet with a small amount of food.

Serious risks include allergic reactions such as rash, angioedema or anaphylaxis, gastrointestinal bleeding or ulcer formation, and rare but severe liver injury. Patients should seek immediate medical attention if they experience signs of these conditions.

Migralgin should be avoided by individuals with a known allergy to aspirin, paracetamol or caffeine, those with active peptic ulcer disease, severe liver impairment, uncontrolled hypertension, or who are taking anticoagulants without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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