Product image of Migralgin (Paracetamol, Acetylsalicylic Acid, Caffeine) supplied by GNH India

Migralgin

Active Ingredient:
Paracetamol, Acetylsalicylic Acid, Caffeine
Origin:
EU

Migralgin (Paracetamol, Acetylsalicylic Acid, Caffeine)

Paracetamol, Acetylsalicylic Acid, Caffeine, the active ingredient in Migralgin, is a combination analgesic presented as a combination oral tablet for oral use. It treats headache, migraine, fever and mild to moderate pain in adults.

GNH India supplies Migralgin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Opella Healthcare Slovakia S.R.O.

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Indications & Clinical Uses

  • Migralgin, a combination analgesic, relieves pain and fever by inhibiting prostaglandin synthesis and enhancing analgesic response.
  • Headache: provides rapid relief of tension‑type and migraine‑associated headache.
  • Fever: lowers elevated body temperature in febrile conditions.
  • Pain: alleviates mild to moderate musculoskeletal, dental or postoperative pain.
  • Migraine: reduces intensity of migraine attacks when taken early.
  • Dental pain: eases discomfort after dental procedures.

How It Works

  • Paracetamol inhibits central cyclooxygenase activity, reducing prostaglandin synthesis in the brain. Acetylsalicylic acid irreversibly blocks peripheral cyclooxygenase enzymes, decreasing prostaglandin and thromboxane formation that mediate pain and inflammation. Caffeine antagonizes adenosine receptors, producing mild central stimulation and enhancing the analgesic effects of paracetamol and aspirin, resulting in faster and more pronounced symptom relief.

Side Effects

Adverse reactions may occur with Migralgin and are classified by frequency.

Common Side Effects

  • Nausea or upset stomach
  • Heartburn or dyspepsia
  • Insomnia or nervousness
  • Dizziness or light‑headedness
  • Increased heart rate
  • Mild headache

Serious or Rare Side Effects

  • Allergic reactions such as rash, swelling or anaphylaxis
  • Gastrointestinal bleeding or ulceration
  • Severe liver injury or hepatitis
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Thrombocytopenia or clotting disorders
  • Severe hypertension or cardiac arrhythmias

Precautions & Warnings

  • Before using Migralgin, consider the following safety measures.
  • Assess liver function: avoid in patients with severe hepatic impairment.
  • Assess renal function: use cautiously in renal disease.
  • Avoid in known aspirin allergy: risk of hypersensitivity reactions.
  • Limit alcohol intake: increased risk of liver injury.
  • Pregnancy and breastfeeding: consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Migralgin can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors: risk of bleeding.
  • Methotrexate: enhanced toxicity.
  • Lithium: increased serum lithium levels.

Moderate Interactions (Monitor Closely)

  • CYP1A2 inhibitors (e.g., fluoroquinolones): may raise caffeine levels.
  • Diuretics: possible reduced renal clearance of aspirin.
  • Alcohol: additive hepatotoxicity.

Frequently Asked Questions

Migralgin is an over‑the‑counter combination analgesic used to relieve headache, migraine, fever and mild to moderate pain such as musculoskeletal, dental or postoperative discomfort. It works by targeting prostaglandin pathways and adding caffeine to enhance pain relief.

Paracetamol reduces central prostaglandin production, lowering pain perception and fever. Aspirin irreversibly inhibits peripheral cyclooxygenase, decreasing inflammation and platelet aggregation. Caffeine blocks adenosine receptors, providing mild stimulation and increasing the analgesic potency of the other two ingredients, resulting in faster and stronger symptom control.

The appropriate dose of Migralgin is determined by the prescribing healthcare professional based on the individual’s age, weight, medical history and the severity of symptoms. Patients should follow the prescriber’s instructions and never exceed the recommended amount on the product label.

Safety of Migralgin in pregnancy or while breastfeeding has not been definitively established. Women who are pregnant, planning pregnancy, or nursing should consult their physician before using the product to weigh potential benefits against possible risks.

To order Migralgin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑ingredient analgesics, Migralgin combines paracetamol, aspirin and caffeine, offering a broader mechanism of action that can provide faster and more complete relief for headache and migraine. It may be preferred when a patient needs both anti‑inflammatory and antipyretic effects, but individual response and tolerance vary.

Migralgin should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and heat. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Migralgin is taken orally, usually with a full glass of water. It can be taken with or without food, but patients who experience stomach upset may prefer taking it with a meal. The exact timing and frequency should follow the prescriber’s directions.

Serious risks include allergic reactions such as rash, swelling or anaphylaxis, gastrointestinal bleeding or ulceration, severe liver injury, and rare skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice any of these severe symptoms.

Migralgin should be avoided by individuals with known hypersensitivity to paracetamol, aspirin or caffeine, those with active peptic ulcer disease, severe liver or kidney impairment, uncontrolled hypertension, and patients on anticoagulant therapy unless advised by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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